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| 1 | Structure and properties of electrodeposited Fe–Ni–W alloys with different levels of tungsten content: A comparative study显示文摘 | Fengjiao He Juan Yang Tongxin Lei Chunyan Gu | 2007 | Applied Surface Science2007，，18： | 1 |
| 2 | Engineering Pt heterogeneous catalysts for accelerated liquid–solid redox conversion in Li-S batteries显示文摘The shuttle effect caused by soluble lithium polysulfides (LiPSs) deteriorates multiphase transformation reaction kinetics of sulfur species,and gives rise to an unserviceable lithium-sulfur (Li-S) battery.Catalysis,as a process optimization approach,offers an option to eliminate the intrinsic issues.However,exploring and understanding the role of catalysts on electrode reaction remains critical bottlenecks,particularly as they are prone to continuous evolution under complex dynamic environment.Herein,platinum nanoparticles loaded on MXene nanosheets,as sulfur host,and the action of catalysts on the reaction process are investigated via ex-situ monitors upon solid–liquid–solid chemical transformation of sulfur species.These traces confirm that the high performance originates from electron transfer between catalysts and LiPSs,which lowers the nucleation barrier from liquid LiPSs to solid Li_(2)S/Li_(2)S_(2).Further,the accelerated liquid–solid conversion can alleviate the accumulation of LiPSs,and boost the reaction kinetics in Li-S batteries.The findings corroborate the electronic modulation between catalysts and LiPSs,which is a generalizable strategy to optimize energy conversion efficiency of Li-S batteries. | Qinhua Gu Yujie Qi Wuxing Hua Tongxin Shang Junnan Chen Luozhen Jiang Lina Li Ming Lu Yixiao Zhang Xi Liu Ying Wan Bingsen Zhang | 2022 | Journal of Energy Chemistry2022，31，6： | 1 |
| 3 | Edge-face chromatic number of Halin-graphs显示文摘Definition 1. Assume that G(V, E, F)is a 3-connected plane graph. Remove all edges on the boundary of a face f0 whose degree of all vertices of $ V(f-0)$ is 3 such that G becomes a tree T whose degree of all vertices except those of V(f0) is at least 3. Then G is called a Halin-graph, f0 | Zhongfu Zhang Xinzhong Lu Linzhong Liu Jianfang Wang Tongxin Gu | 1999 | Chinese Science Bulletin1999，44，2： | 1 |
| 4 | Crosstalk between metabolic reprogramming and epigenetics in cancer:updates on mechanisms and therapeutic opportunities显示文摘Reversible,spatial,and temporal regulation of metabolic reprogramming and epigenetic homeostasis are prominent hallmarks of carcinogenesis.Cancer cells reprogram their metabolism to meet the high bioenergetic and biosynthetic demands for vigorous proliferation.Epigenetic dysregulation is a common fea-ture of human cancers,which contributes to tumorigenesis and maintenance of the malignant phenotypes by regulating gene expression.The epigenome is sensitive to metabolic changes.Metabolism produces various metabolites that are substrates,cofactors,or inhibitors of epigenetic enzymes.Alterations in metabolic pathways and fluctuations in intermediate metabolites convey information regarding the intracellular metabolic status into the nucleus by modulating the activity of epigenetic enzymes and thus remodeling the epige-netic landscape,inducing transcriptional responses to heterogeneous metabolic requirements.Cancer metabolism is regulated by epigenetic machinery at both transcriptional and post-transcriptional levels.Epigenetic modifiers,chromatin remodelers and non-coding RNAs are integral contributors to the regulatory networks involved in cancer metabolism,facilitating malignant transformation.However,the significance of the close connection between metabolism and epi-genetics in the context of cancer has not been fully deciphered.Thus,it will be constructive to summarize and update the emerging new evidence support-ing this bidirectional crosstalk and deeply assess how the crosstalk between metabolic reprogramming and epigenetic abnormalities could be exploited to optimize treatment paradigms and establish new therapeutic options.In this review,we summarize the central mechanisms by which epigenetics and metabolism reciprocally modulate each other in cancer and elaborate upon and update the major contributions of the interplays between epigenetic aber-rations and metabolic rewiring to cancer initiation and development.Finally,we highlight the potential therapeutic opportunities for hematological malig-nancies and solid tumors by targeting this epigenetic-metabolic circuit.In summary,we endeavored to depict the current understanding of the coordi-nation between these fundamental abnormalities more comprehensively and provide new perspectives for utilizing metabolic and epigenetic targets for cancer treatment. | Tongxin Ge Xiang Gu Renbing Jia Shengfang Ge Peiwei Chai Ai Zhuang Xianqun Fan | 2022 | Cancer Communications2022，42，11： | 0 |
| 5 | Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m6A RNA methylation in ocular melanoma显示文摘Background Diversified histone deacetylation inhibitors(HDACis)have demonstrated encouraging outcomes in multiple malignancies.N6-methyladenine(m6A)is the most prevalent messenger RNA modification that plays an essential role in the regulation of tumorigenesis.Howbeit,an in-depth understanding of the crosstalk between histone acetylation and m6A RNA modifications remains enigmatic.This study aimed to explore the role of histone acetylation and m6A modifications in the regulation of tumorigenesis of ocular melanoma.Methods Histone modification inhibitor screening was used to explore the effects of HDACis on ocular melanoma cells.Dot blot assay was used to detect the global m6A RNA modification level.Multi-omics assays,including RNA-sequencing,cleavage under targets and tagmentation,single-cell sequencing,methylated RNA immunoprecipitation-sequencing(meRIP-seq),and m6A individual nucleotide resolution cross-linking and immunoprecipitation-sequencing(miCLIP-seq),were performed to reveal the mechanisms of HDACis on methyltransferase-like 14(METTL14)and FAT tumor suppressor homolog 4(FAT4)in ocular melanoma.Quantitative real-time polymerase chain reaction(qPCR),western blotting,and immunofluorescent staining were applied to detect the expression of METTL14 and FAT4 in ocular melanoma cells and tissues.Cell models and orthotopic xenograft models were established to determine the roles of METTL14 and FAT4 in the growth of ocular melanoma.RNA-binding protein immunoprecipitation-qPCR,meRIP-seq,miCLIP-seq,and RNA stability assay were adopted to investigate the mechanism by which m6A levels of FAT4 were affected.Results First,we found that ocular melanoma cells presented vulnerability towards HDACis.HDACis triggered the elevation of m6A RNA modification in ocular melanoma.Further studies revealed that METTL14 served as a downstream candidate for HDACis.METTL14 was silenced by the hypo-histone acetylation status,whereas HDACi restored the normal histone acetylation level of METTL14,thereby inducing its expression.Subsequently,METTL14 served as a tumor suppressor by promoting the expression of FAT4,a tumor suppressor,in a m6A-YTH N6-methyladenosine RNA-binding protein 1-dependent manner.Taken together,we found that HDACi restored the histone acetylation level of METTL14 and subsequently elicited METTL14-mediated m6A modification in tumorigenesis.Conclusions These results demonstrate that HDACis exert anti-cancer effects by orchestrating m6A modification,which unveiling a“histone-RNA crosstalk”of the HDAC/METTL14/FAT4 epigenetic cascade in ocular melanoma. | Ai Zhuang Xiang Gu Tongxin Ge Shaoyun Wang Shengfang Ge Peiwei Chai Renbing Jia Xianqun Fan | 2023 | Cancer Communications2023，43，11： | 0 |
| 6 | Tyrosine promotes anthocyanin biosynthesis in pansy(Viola×wittrockiana)by inducing ABA synthesis显示文摘Viola×wittrockiana(pansy)is an important ornamental plant,particularly during winter and spring.In previous studies,we found that the tyrosine decarboxylase gene of pansy(VwTYDC)was expressed differently in blotched and non-blotched areas of pansy petals,suggesting that tyrosine may have a role in anthocyanin biosynthesis.In this study,we found that virus-induced gene silencing of VwTYDC caused an accumulation of pink pigmentation in pansy petals.Likewise,exogenous tyrosine treatment(TYRT)induced the formation of black stripes in nonblotched petal areas.Metabolome analysis indicated that the contents of two anthocyanins,cyanidin-3-O-glucoside and cyanidin-3-O-rutinoside,increased significantly in the TYRT areas.RT-qPCR results revealed that the anthocyanin-related genes VwHCT,VwC3′H,VwCHS,and VwUGT were upregulated in the same areas.Transcriptome analysis revealed that four genes involved in the abscisic acid(ABA)biosynthesis pathway(VwNCED,VwABA2,VwAAO3,and VwCYP707A)were significantly upregulated in the same TYRT areas.ABA content was measured by ESI-HPLCMS/MS,and ABA content was significantly higher in TYRT areas than in control areas.In addition,when exogenous ABA was spread onto nonblotched petal areas,anthocyanin biosynthesis genes were upregulated just as with tyrosine.Thus,transcriptome and metabolite analyses revealed a possible novel regulatory network for anthocyanin biosynthesis in which tyrosine induces ABA synthesis and ABA then promotes anthocyanin biosynthesis in pansy petals. | Zheng Cui Jia Gu Jie Li Anjin Zhao Yingge Fu Tongxin Wang Tingge Li Xueqing Li Yuhui Sheng Ying Zhao Xiqiang Song Yang Zhou Ting Peng Jian Wang | 2022 | Tropical Plants2022，1，1： | 0 |
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