|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer显示文摘AIM:To evaluate the safety and clinical application of high-intensity focused ultrasound(HIFU)therapy for unresectable pancreatic cancer(PC).METHODS:Thirty PC patients(16 cases in stage III and 14 cases in stage IV)with visualized pancreatic tumors were admitted for HIFU therapy as an optional local therapy in addition to systemic chemotherapy or chemoradiotherapy.Informed consent was obtained.This study began at the end of 2008 and was approved by the ethics committee of our hospital[Institutional Review Board(IRB):890].The HIFU device used was the FEP-BY02(Yuande Bio-Medical Engineering,Beijing,China).RESULTS:The mean tumor size after HIFU therapy changed to 30.9±1.7 mm from 31.7±1.7 mm at pre-therapy.There were no significant changes in tumor size,mean number of treatment sessions(2.7±0.1 mm),or mean total treatment time(2.4±0.1 h).The rate of symptom relief effect was 66.7%.The effectiveness of primary lesion treatment was as follows:complete response,0;partial response,4;stable disease,22;progressive disease,4.Treatment after HIFU therapy included 2 operations,24 chemotherapy treatments,and 4 best supportive care treatments.Adverse events occurred in 10%of cases,namely pseudocyst formation in 2 cases and mild pancreatitis development in 1.However,no severe adverse events occurred in this study.CONCLUSION:We suggest that HIFU therapy is safe and has the potential to be a new method of combination therapy for PC. | Atsushi Sofuni Fuminori Moriyasu Takatomo Sano Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro Mukai Mitsuru Fujita Takao Itoi | 2014 | World Journal of Gastroenterology2014，20，28： | 12 |
| 2 | Endoscopic ultrasound‐guided choledochoantrostomy as an alternative extrahepatic bile duct drainage method in pancreatic cancer with duodenal invasion显示文摘 | Takao Itoi Fumihide Itokawa Takayoshi Tsuchiya Shujiro Tsuji Ryosuke Tonozuka | 2013 | Digestive Endoscopy2013，，： | 2 |
| 3 | Endoscopic double stenting for the treatment of malignant biliary and duodenal obstruction due to pancreatic cancer显示文摘 | Ryosuke Tonozuka Takao Itoi Atsushi Sofuni Fumihide Itokawa Fuminori Moriyasu | 2013 | Digestive Endoscopy2013，，： | 2 |
| 4 | Cloning and Nucleotide Sequence of the Pullulanase Gene of Thermus thermophilus HB8 and Production of the Enzyme in Escherichia coli显示文摘 | Tomiyasu K Yato K Yasuda M Tonozuka T Ibuka A Sakai H | | 0，，09： | 1 |
| 5 | Effect of Ce addition on the sensitization properties of stainless steels 显示文摘 | Watanabe Y Kain V Tonozuka T | 2000 | Scripta Materialia2000，42，： | 1 |
| 6 | The deletion of aminoterminal domain in Thermoactinomyees vulgaris R-47 alpha-amylases: effects of domain N on activity, specificity, stability and dimerization显示文摘 | Yokota T Tonozuka T Kamitori S | 2001 | Biosci Biotech Bioch2001，65，2： | 1 |
| 7 | Effect of Ce Addition on the Sensitization Properties of Stainless Steels 显示文摘 | WATANABE Y KAIN V TONOZUKA T | 2000 | ScriptaMaterialia2000，42，3： | 1 |
| 8 | Complex structures of Ther- moactinomyces vulgaris R-47 α -amylase I with maltooligosaccharides demonstrate the role of domain N acting as a starch-binding domain显示文摘 | Abe A Tonozuka T Sakano Y | 2004 | J Mol Biol2004，335，3： | 1 |
| 9 | Efficacy and safety of endoscopic papillary large balloon dilation for large bile duct stones in elderly patients显示文摘 | Tonozuka R Itoi T Sofuni A | 2014 | Dig Dis Sci2014，59，9： | 1 |
| 10 | A neopullulanase - typeα - amylase gene from Thermoactinomyces vulgaris R-47显示文摘 | Tonozuka T OhtsukaM Mogi S I Sakai H Ohta T Sakano Y | 1993 | Biosci Biotech Biochem1993，57，3： | 1 |
| 11 | Structural insights into substrate specificity and function of glucodextranase 显示文摘 | Mizuno M Tonozuka T Suzuki S | 2004 | J Biol Chem2004，279，10： | 1 |
| 12 | Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation显示文摘 | Ha NC Tonozuka T Stamos JL | 2004 | Mol Cell2004，15，4： | 1 |
| 13 | Molecular cloning and characterization of an enzyme hydrolyzing p -nitrophenyl -alpha -D -glueoside from Bacillos stearothermophilus SA0301显示文摘 | Kobayashi A Tonozuka T Sato K | | 0，，02： | 1 |
| 14 | Endoscopic double stenting for the treatment of malignant biliary and duodenal ob- struction due to pancreatic cancer 显示文摘 | TONOZUKA R ITOI T SOFUNI A | 2013 | Dig Endosc2013，25，2： | 1 |
| 15 | Three-dimensional structure of glucodextranase, a glycoside hydrolase family 15 enzyme 显示文摘 | Mizuno M Tonozuka T Ichikawa K | 2005 | Biologia Bratislava2005，60，16： | 1 |
| 16 | Novel single transluminal gateway transcystic multiple drainages after EUS-guided drainage for complicated multilocular walled-off necrosis (with videos)显示文摘 | Shuntaro Mukai Takao Itoi Atsushi Sofuni Fumihide Itokawa Toshio Kurihara Takayoshi Tsuchiya Kentaro Ishii Shujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka Mitsuyoshi Honjo Fuminori Moriyasu | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 17 | Construction of chimeric cyclodextrin glucanotransferases from Bacillus circulans All and Paenibacillus macerans IAM1243 and analysis of their product specificity显示文摘 | Vichien Rimphanitchayakit Takashi Tonozuka Yoshiyuki Sakano | | 0，，14： | 1 |
| 18 | Real-time virtual sonography visualization and its clinical application in biliopancreatic disease显示文摘AIM:To evaluate the usefulness of real-time virtual sonography(RVS)in biliary and pancreatic diseases.METHODS:This study included 15 patients with biliary and pancreatic diseases.RVS can be used to observe an ultrasound image in real time by merging the ultrasound image with a multiplanar reconstruction computed tomography(CT)image,using pre-scanned CT volume data.The ultrasound used was EUB-8500with a convex probe EUP-C514.The RVS images were evaluated based on 3 levels,namely,excellent,good and poor,by the displacement in position.RESULTS:By combining the objectivity of CT with free scanning using RVS,it was possible to easily interpret the relationship between lesions and the surrounding organs as well as the position of vascular structures.The resulting evaluation levels of the RVS images were12 excellent(pancreatic cancer,bile duct cancer,cholecystolithiasis and cholangiocellular carcinoma)and 3 good(pancreatic cancer and gallbladder cancer).Compared with conventional B-mode ultrasonography and CT,RVS images achieved a rate of 80%superior visualization and 20%better visualization.CONCLUSION:RVS has potential usefulness in objective visualization and diagnosis in the field of biliary and pancreatic diseases. | Atsushi Sofuni Takao Itoi Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro Mukai Fuminori Moriyasu | 2013 | World Journal of Gastroenterology2013，19，42： | 1 |
| 19 | Mechanism of phos- phorylation-dependent binding of APC to β-catenin and its role in β-catenin degradation 显示文摘 | Ha NC Tonozuka T Stamos JL | 2004 | Cell2004，15，4： | 1 |
| 20 | Rho-kinase inhibition ameliorates peritoneal fibrosis and migiogenesis in a rat model of peritoneal sclerosis显示文摘 | Washida N Wakino S Tonozuka Y | 2011 | Nephrol Dial Transplant2011，4，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员