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| 1 | Spontaneous fungal peritonitis: Micro-organisms, management and mortality in liver cirrhosis-A systematic review显示文摘BACKGROUND Spontaneous peritonitis is an infection of ascitic fluid without a known intraabdominal source of infection. spontaneous fungal peritonitis (SFP) is a potentially fatal complication of decompensated cirrhosis, defined as fungal infection of ascitic fluid in the presence of ascitic neutrophil count of greater than 250 cells/mL. AIM To determine the prevalence of fungal pathogens, management and outcomes (mortality) of SFP in critically ill cirrhotic patients. METHODS Studies were identified using PubMed, EMBASE, Cochrane Central Register of Controlled Trials and Scopus databases until February 2019. Inclusion criteria included intervention trials and observation studies describing the association between SFP and cirrhosis. The primary outcome was in-hospital, 1-mo, and 6- mo mortality rates of SFP in cirrhotic patients. Secondary outcomes were fungal microorganisms identified and in hospital management by anti-fungal medications. The National Heart, Lung and Blood Institute quality assessment tools were used to assess internal validity and risk of bias for each included study. RESULTS Six observational studies were included in this systematic review. The overall quality of included studies was good. A meta-analysis of results could not be performed because of differences in reporting of outcomes and heterogeneity of the included studies. There were 82 patients with SFP described across all the included studies. Candida species, predominantly Candida albicans was the fungal pathogen in majority of the cases (48%-81.8%) followed by Candida krusei (15%- 25%) and Candida glabrata (6.66%-20%). Cryptococcus neoformans (53.3%) was the other major fungal pathogen. Antifungal therapy in SFP patients was utilized in 33.3% to 81.8% cases. The prevalence of in hospital mortality ranged from 33.3% to 100%, whereas 1-mo mortality ranged between 50% to 73.3%. CONCLUSION This systematic review suggests that SFP in end stage liver disease patient is associated with high mortality both in the hospital and at 1-mo, and that antifungal therapy is currently underutilized. | Tooba Tariq Furqan B Irfan Mehdi Farishta Brian Dykstra Eric Martin Sieloff Archita P Desai | 2019 | World Journal of Hepatology2019，11，7： | 7 |
| 2 | Secondary angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease: Results from the nationwide inpatient sample显示文摘BACKGROUND Chronic kidney disease is associated with angiodysplasia of gastrointestinal tract leading to increased risk of gastrointestinal bleeding.AIM To determine the nationwide prevalence,trends,predictors and resource utilization of angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease hospitalizations.METHODS The Nationwide Inpatient Sample database from 2009 to 2014,was utilized to conduct a retrospective study on patients with angiodysplasia associatedgastrointestinal bleeding and end-stage renal disease.Hospitalizations with endstage renal disease were included in the Nationwide Inpatient Sample database and a subset of hospitalizations with end-stage renal disease and angiodysplasiaassociated gastrointestinal bleeding were identified with International Classification of Diseases,9th revision,Clinical Modification codes for both endstage renal disease(585.6)and angiodysplasia(569.85,537.83).RESULTS The prevalence of angiodysplasia-associated gastrointestinal bleeding was 0.45%(n=24709)among all end-stage renal disease patients(n=5505252)that were hospitalized.Multivariate analysis indicated that the following were significant factors associated with higher odds of angiodysplasia associated-gastrointestinal bleeding in end-stage renal disease patients:an increasing trend from 2009-2014(P<0.01),increasing age(P<0.0001);African American race(P=0.0206);increasing Charlson-Deyo Comorbidity Index(P<0.01);hypertension(P<0.0001);and tobacco use(P<0.0001).Diabetes mellitus(P<0.0001)was associated with lower odds of angiodysplasia associated-gastrointestinal bleeding in end-stage renal disease patients.In comparison with urban teaching hospitals,rural and urban nonteaching hospitals were associated with decreased odds of angiodysplasia associated-gastrointestinal hemorrhage.CONCLUSION Angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease patients showed an increasing trend from 2009-2014.Advanced age,African American race,overall high comorbidities,hypertension and smoking were significant factors for angiodysplasia-associated gastrointestinal bleeding in bleeding in these patients. | Tooba Tariq Patrick Karabon Furqan B Irfan Sachin Goyal Matthew Masaru Mayeda Austin Parsons Stephanie Judd Murray Ehrinpreis | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，10： | 3 |
| 3 | Anti-encystment and amoebicidal activity of Lonicera japonica Thunb. and its major constituent Chlorogenic acid in vitro显示文摘Objective:To examine the acanthamoebicidal effects of ethyl acetate,aqueous and butanol fractions of dried flower buds of Lonicera japonica(L.japonica) Thunb.(Flos Lonicerae) in vitro.Methods:Acanthamoeba triangularis isolates were obtained from environmental water samples and identified by PCR.They were exposed to ethyl acetate,water and butanol fractions of L.japonica Thunb.at concentrations ranging from 0.5 mg/m L to 1.5 mg/m L.The extracts were evaluated for growth inhibition at 24,48 and 72 h,respectively.Chlorogenic acid at a concentration of 1 mg/mL was examined for inhibition of encystment.Results:Ethyl acetate fraction at a concentration of 1.5 mg/mL evoked a significant reduction of trophozoite viability by 48.9% after 24 h,49.2% after 48 h and 33.7% after 72 h Chlorogenic acid,the major active constituent of L.japonica Thunb.at the concentration of 1 mg/mL reduced the cysts/trophozoite ratio by 100% after 24 h,84.0% after 48 h and 72.3% after 72 h.This phenolic compound at concentration of 1 mg/mL concurrent with 0.6% hydrogen peroxide inhibited hydrogen peroxide-induced encystment by 92.8% at 72 h.Conclusions:Results obtained from this study show that ethyl acetate fraction at 1.5 mg/m L is the most potent fraction of L.japonica Thunb.and its major constituent chlorogenic acid showed the remarkable inhibition of encystment at a concentration of 1 mg/mL. | Tooba Mahboob Abdul-Majid Azlan Tian-Chye Tan Chandramathi Samudi Shamala Devi Sekaran Veeranoot Nissapatorn Christophe Wiart | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，9： | 2 |
| 4 | 可作为天然产物资源的药用植物研究进展(英文)显示文摘在制药行业中,天然产物是药物来源之一,而天然产物的主要来源则为药用植物。药用植物常用来治疗某些特定疾病,并可能成为潜在药物的来源。菲律宾卫生部批准了10种药用植物,分别蒜(Al ium sativum)、艾纳香(Blumea balsamifera)、翅荚决明(Cassia alata)、柠檬薄荷(Clinopodium douglasii)、福建茶(Ehretia microphyl a)、苦瓜(Momordica charantia)、草胡椒(Peperomia pellucida)、番石榴(Psidium guajava)、使君子(Quisqualis indica)和黄荆(Vitex negundo)。研究证明这些药用植物能够治疗感染和某些疾病。我们发现蒜能治疗伤口、高血压和牙痛;艾纳香对高血压的利尿治疗有效;翅荚决明能治疗疥疮、真菌感染、脚癣、黄癣、环癣;柠檬薄荷能治疗肌肉疼痛、关节炎、风湿病、咳嗽、头痛;小叶厚壳树能治疗腹泻和胃痛;苦瓜能治疗糖尿病;草胡椒能治疗痛风和风湿病;番石榴能治疗伤口和腹泻;使君子是一种驱虫药;而黄荆能治疗咳嗽、哮喘和发热。综上,这10种药用植物都含有可用作潜在药物来源的天然产物。然而,仍有许多民族植物物种尚未得到充分研究,并可能成为潜在药物的来源。因此,应该对其他植物物种进行更多的研究,特别是对于实际应用的植物。 | Henry Ivanz A.Boy Alfred Joshua H.Rutilla Kimbberly A.Santos Allister Matthew T.Ty Alicia I.Yu Tooba Mahboob Jitbanjong Tangpoong Veeranoot Nissapatorn | 2018 | Digital Chinese Medicine2018，1，2： | 1 |
| 5 | The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children显示文摘 | Soheila Alyasin Tooba Momen Sara Kashef | 2011 | Allergy Asthma Immunol Res2011，3，4： | 1 |
| 6 | An Implementation of Haar Wavelet Based Method for Numerical Treatment of Time-fractional Schrdinger and Coupled Schrdinger Systems显示文摘The objective of this paper is to solve the timefractional Schr¨odinger and coupled Schr¨odinger differential equations(TFSE) with appropriate initial conditions by using the Haar wavelet approximation. For the most part, this endeavor is made to enlarge the pertinence of the Haar wavelet method to solve a coupled system of time-fractional partial differential equations. As a general rule, piecewise constant approximation of a function at different resolutions is presentational characteristic of Haar wavelet method through which it converts the differential equation into the Sylvester equation that can be further simplified easily. Study of the TFSE is theoretical and experimental research and it also helps in the development of automation science,physics, and engineering as well. Illustratively, several test problems are discussed to draw an effective conclusion, supported by the graphical and tabulated results of included examples, to reveal the proficiency and adaptability of the method. | Najeeb Alam Khan Tooba Hameed | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 1 |
| 7 | Association of serum immunoglobulins levels and eye injuries in sulfur mustard exposed: Sardasht-Iran Cohort Study显示文摘 | Hassan Ghasemi Ail Mostafaie Roya Yaraee Zuhair Mohammad Hassan Abbas Rezaei Mahmoud Mahmoudi Soghrat Faghihzadeh Mohammad-Reza Soroush Sussan K. Ardestani Mahmoud Babaei Mohammadreza Jalali-Nadoushan Ali Khamesipour Mohammad Ghassemi-Broumand Tooba Ghaza | 2013 | International Immunopharmacology2013，，： | 1 |
| 8 | Doppler findings in intrapartum fetal distress显示文摘 | Eslamian L Tooba K | 2011 | Biomed Eng Online2011，10，： | 1 |
| 9 | Immunomodulatory activity of a protein isolated from garlic extract on delayed type hypersensitivity显示文摘 | Tooba Ghazanfari | 2002 | International Immunopharmacology2002，，2： | 1 |
| 10 | Immunomodulatory activity of a protein isolated from garlic extract on delayed type hyper-sensitivi- ty显示文摘 | Tooba Ghazanfari | 2002 | International Immunopharmacology2002，，： | 1 |
| 11 | Strong enhancement of the chemiluminescence of the cerium(IV)-thiosulfate reaction by carbon dots,and its application to the sensitive determination of dopamine显示文摘 | MOHAMMAD A JAMSHID L M TOOBA H | 2014 | Microchimica Acta2014，181，56： | 1 |
| 12 | Some non-linear height–diameter models performance for mixed stand in forests in Northwest Iran显示文摘This study evaluated the total height of trees based on diameter at breast height by using 23 widely used height-diameter non-linear regression models for mixed-species forest stands consisting of Caucasian oak,field maple,and hornbeam from forests in Northwest Iran.1920 trees were measured in 6 sampling plots(every sampling plot has 1 ha area).The fit of the best height–diameter models for each species were compared based on R2,Root Mean Square Error(RMSE),Akaike information criterion(AIC),standard error,and relative ranking performance criteria.In the final step,verification of results was performed by paired sample t-test to compare the observed height and estimated height.Results showed that among 23 height-diameter models,the best models were obtained from the top five ones including Modified-logistic,Prodan,Sibbesen,Burkhart,and Exponential.Comparison between the actual observed height and estimated height for Caucasian oak showed that Modified–Logistic,Prodan,Sibbesen,Burkhart,and Exponential performed better than the others,respectively(There were no statistically significant differences between observed heights and predicted height(p≥0.05)).Prodan,Modified-Logistic,Burkhart,and Loetch evaluated field maple tree height correctly,and Modified-Logistic,Burkhart,and Loetch had better fitness compared to the others for hornbeam,respectively.Although other models were introduced as appropriate criteria,they could not reliably predict the height of trees.Using the Rank analysis,the Modified-Logistic model for the Caucasian oak and Prodan model for field maple and hornbeam had the best performance.Finally,to complement the results of this study,it is suggested to assess how environmental factors such as elevation,climate parameters,forest protection policy and forest structure will modify height-diameter allometry models and will enhance the prediction accuracy of tree heights prediction in mixed stands. | Roya ABEDI Tooba ABEDI | 2020 | Journal of Mountain Science2020，17，5： | 0 |
| 13 | A Metaheuristic Approach to Optimize European Call Function with Boundary Conditions显示文摘The purpose of this paper is to investigate the pricing European call option valuation problems under the exercise price,maturity,risk-free interest rate,and the volatility function. An advance methodology,Chebyshev simulated annealing neural network(Ch SANN),is enforced for the Black-Scholes(B-S) model with boundary conditions. Our scheme is stable and easy to implement on B-S equation,for arbitrary volatility and arbitrary interest rate values. Also,the comparative results demonstrate that the attained approximate solutions are converging towards the exact solution. The graphical results show that the increasing flow of the European call option as the exponential increase takes place in assets. The presented algorithm can be further applied to other financial models with certain boundary conditions. The algorithm of the method shows that the approach can also be easily employed on time-fractional B-S equation. | Najeeb Alam KHAN Oyoon Abdul RAZZAQ Tooba HAMEED | 2018 | Journal of Systems Science and Information2018，9，3： | 0 |
| 14 | Homotopy perturbation aided optimization procedure with applications to oscillatory fractional order nonlinear dynamical systems显示文摘This paper presents an approximate solution of nonlinear fractional differential equations(FDEs)that exhibit an oscillatory behavior by using a metaheuristic technique.The solutions of the governing equations are approximated by using homotopy perturbation method(HPM)along with the fractional derivative in the Caputo sense.The designed methodology is based on a weighted series of HPM in conjunction with a nature-inspired algorithm.The idea is instantly fascinated by the researchers on the consequent implementation of nature-inspired learning algorithms such as a Cuckoo search algorithm(CSA).The usage of CSA has accelerated the minimized search path of error to the convergent values of the solution.The validity and accuracy of the proposed technique are ascertained by calculating the approximate solution and the error norms which ensure the convergence of the approximation that can be further increased.The critical analysis is also provided by the numerical simulation of two different test models.Discussion of key points has been determined by the tabulation of numerical values and graphs.Comparative study of the results with known numerical technique is also performed. | Najeeb Alam Khan Tooba Hameed Samreen Ahmed | 2019 | International Journal of Modeling, Simulation, and Scientific Computing2019，10，4： | 0 |
| 15 | Behavioral effects of a four-wing attractor with circuit realization: a cryptographic perspective on immersion显示文摘In this paper,we propose an innovative chaotic system,combining fractional derivative and sinehyperbolic nonlinearity with circuit execution.The study of this system is conducted via an analog circuit simulator,using two anti-parallel semiconductor diodes to provide hyperbolic sine nonlinearity,and to function as operational amplifiers.The multi-stability of the system is also enhanced with the help of multi-equilibrium points for distinct real orders of system.The system explores the generation of a four-wing attractor in different phases,both numerically and electronically.By changing the input parameters of the system,different graphs are generated for current flow in state,phase,and space,to confirm the precision of the fractional order derivatives.A reasonable simulation shows that the deliberate circuit provides effective chaos in terms of speed and accuracy,which is comensurate with the numerical simulation.This nonlinear chaotic behavior is utilized to encrypt sound(.wav),images(.jpg),and animated(.gif)data which are a major requirement for the security of communication systems.The proposed circuit performs chaos and cryptographic tasks with high-effective analog computation,and constitutes a novel approach to this area of research. | Najeeb Alam Khan Muhammad Ali Qureshi Tooba Hameed Saeed Akbar Saif Ullah | 2020 | Communications in Theoretical Physics2020，72，12： | 0 |
| 16 | No signature of selection on the C-terminal region of glucose transporter 2 with the evolution of avian nectarivory显示文摘Background:Flying birds,especially those that hover,need to meet high energetic demands.Birds that meet this demand through nectarivory face the added challenges of maintaining homeostasis in the face of spikes in blood sugar associated with nectar meals,as well as transporting that sugar to energetically demanding tissues.Nectarivory has evolved many times in birds and we hypothesized that the challenges of this dietary strategy would exert selective pressure on key aspects of metabolic physiology.Specifically,we hypothesized we would find convergent or parallel amino acid substitutions among different nectarivorous lineages in a protein important to sensing,regulating,and transporting glucose,glucose transporter 2(GLUT2).Methods:Genetic sequences for GLUT2 were obtained from ten pairs of nectarivorous and non-nectarivorous sister taxa.We performed PCR amplification of the intracellular C-terminal domain of GLUT2 and adjacent protein domains due to the role of this region in determination of transport rate,substrate specificity and glucosensing.Results:Our findings have ruled out the C-terminal regulatory region of GLUT2 as a target for selection by sugar-rich diet among avian nectarivores,though selection among hummingbirds,the oldest avian nectarivores,cannot be discounted.Conclusion:Our results indicate future studies should examine down-stream targets of GLUT2-mediated glucosensing and insulin secretion,such as insulin receptors and their targets,as potential sites of selection by nectarivory in birds. | Alexander M.Myrka Tooba Shah Jason T.Weir Kenneth C.Welch Jr. | 2020 | Avian Research2020，11，4： | 0 |
| 17 | Deciphering key genes involved in cisplatin resistance in kidney renal clear cell carcinoma through a combined in silico and in vitro approach显示文摘The low survival rate of Kidney renal clear cell carcinoma(KIRC)patients is largely attributed to cisplatin resistance.Rather than focusing solely on individual proteins,exploring protein-protein interactions could offer greater insight into drug resistance.To this end,a series of in silico and in vitro experiments were conducted to identify hub genes in the intricate network of cisplatin resistance-related genes in KIRC chemotherapy.The genes involved in cisplatin resistance across KIRC were retrieved from the National Center for Biotechnology Information(NCBI)database using search terms as“Kidney renal clear cell carcinoma”and“Cisplatin resistance”.The genes retrieved were analyzed for hub gene identification using the STRING database and Cytoscape tool.Expression and promoter methylation profiling of the hub genes was done using UALCAN,GEPIA,OncoDB,and HPA databases.Mutational,survival,functional enrichment,immune cell infiltration,and drug prediction analyses of the hub genes were performed using the cBioPortal,GEPIA,GSEA,TIMER,and DrugBank databases.Lastly,expression and methylation levels of the hub genes were validated on two cisplatin-resistant RCC cell lines(786-O and A-498)and a normal renal tubular epithelial cell line(HK-2)using two high throughput techniques,including targeted bisulfite sequencing(bisulfite-seq)and RT-qPCR.A total of 124 genes were identified as being associated with cisplatin resistance in KIRC.Out of these genes,MCL1,IGF1R,CCND1,and PTEN were identified as hub genes and were found to have significant(p<0.05)variations in their mRNA and protein expressions and effects on the overall survival(OS)of the KIRC patients.Moreover,an aberrant promoter methylation pattern was found to be associated with the dysregulation of the hub genes.In addition to this,hub genes were also linked with different cisplatin resistance-causing pathways.Thus,hub genes can be targeted with Alvocidib,Estradiol,Tretinoin,Capsaicin,Dronabinol,Metribolone,Calcitriol,Acetaminophen,Acitretin,Cyclosporine,Azacitidine,Genistein,and Resveratrol drugs.As the pathogenesis of KIRC is complex,targeting hub genes and associated pathways involved in cisplatin resistance could bring a milestone change in the drug discovery and management of drug resistance,which might uplift overall survival among KIRC patients. | MUNEEBA MALIK MAMOONA MAQBOOL TOOBA NISAR TAZEEM AKHTER JAVED AHMED UJAN ALANOOD SALGARNI FAKHRIA AAL JOUFI SULTAN SHAFI KALANAZI MOHAMMAD HADI ALMOTARED MOUNIR MSALEM BEKHIT MUHAMMAD JAMIL | 2023 | Oncology Research2023，31，6： | 0 |
| 18 | Takotsubo syndrome with underlying pheochromocytoma显示文摘Takotsubo cardiomyopathy(TTC),also re-ferred as broken heart syndrome,is a type of non-ischemic cardiomyopathy usually preceded by exposure to significant physical or emotional stress.[1]Reported by Sato,et al.[2]in 1990 for the first time,the condition resembles acute coronary syndrome(ACS),characterised by chest pain and dyspnoea.[3]ST-segment elevation and/or T wave inversion and pathological Q waves are pre-sent in almost 40%of patients on electrocardiogram.[4]It is recently established that TTC causative factor is not only an acute emotional stress,but also sudden intracranial events,including haemorrhage,trauma and ischemic events;acute medical diseases such as sepsis and surgical interventions;increased secre-tion of endogenous catecholamines(pheochromocy-toma);and administration of exogenous catechola-minergic agents can contribute to the disease patho-logy.TTC has been recognized by the American College of Cardiology/American Heart Association as a dis-tinctive form of reversible cardiomyopathy. | Tooba Sahar Asaad Akbar Khan Raja Wajid Shabbir | 2021 | Journal of Geriatric Cardiology2021，18，12： | 0 |
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