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| 1 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 2 | Duodenal gangliocytic para ganglioma treated with endoscopic hemostasis and resection显示文摘 | Nagai T Torishima R Nakashima H | 2004 | J Gastroenterol2004，39，3： | 1 |
| 3 | Spontaneous dissection of the superior mesenteric artery in four cases treated with anticoagulation therapy 显示文摘 | Nagai T Torishima R Uchida A | 2004 | Intern Med2004，43，6： | 1 |
| 4 | Saline - assisted endoscopic resection of rectalcarcinoids:eap aspiration meth- od versus simple snare resection显示文摘 | Nagai T Torishima R Nakashima H etal | 2007 | Endoscopy2007，36，3： | 1 |
| 5 | Saline - assisted endoscopic resection of rectal eareinoids : cap aspiration method versus simple snare resection 显示文摘 | Nagai T Torishima R Nakashima H | 2006 | Endoscopy2006，36，3： | 1 |
| 6 | Saline-assisted endoscopic resection of rectal carcinoids: cap aspiration method versus simple snare resection显示文摘 | Nagai T Torishima R Nakashima H | 2004 | Endoscopy2004，36，： | 1 |
| 7 | Saline-Assisted Endoscopic Resection of Rectal Carcinoids: Cap Aspiration Method Versus Simple Snare Resection显示文摘 | T. Nagai R. Torishima H. Nakashima H. Ookawara A. Uchida S. Kai R. Sato K. Murakami T. Fujioka | 2004 | Endoscopy2004，，03： | 1 |
| 8 | Saline-Assisted Endoscopic Resection of Rectal Carcinoids: Cap Aspiration Method Versus Simple Snare Resection显示文摘 | T. Nagai R. Torishima H. Nakashima H. Ookawara A. Uchida S. Kai R. Sato K. Murakami T. Fujioka | 2004 | Endoscopy2004，，03： | 1 |
| 9 | Spontaneous dissection of the superior mesenteric artery in four cases treated with anticoagulation therapy显示文摘 | Nagai T Torishima R Uchida A | 2004 | Intern Med2004，43，6： | 1 |
| 10 | Saline-assisted endoscopic resection of rectal carcinoids: cap aspiration method versus simple snare resection 显示文摘 | Nagai T Torishima R Nakashirna H | 2004 | Endoscopy2004，36，3： | 1 |
| 11 | Saline-assisted Endoscopic resection of rectal carcinoids: capaspiration method versus simple snare resection显示文摘 | NAGAI T TORISHIMA R NAKASHIMA H | 2006 | Endoscopy2006，36，3： | 1 |
| 12 | Duodenal gangliocytic paraganglioma treated with endoscopic hemostasis and resection显示文摘 | Takayuki Nagai Ryutarou Torishima Hiroshi Nakashima Jin Tanahashi Megumi Iwata Hitoshi Ookawara Shigeo Yokoyama Kazuhiro Yada Ryugo Sato Kazunari Murakami Toshio Fujioka | 2004 | Journal of Gastroenterology2004，，3： | 1 |
| 13 | Saline-assisted endoscopic resection of rectal carcinoids:cap aspiration method versus simple snare resection显示文摘 | Nagai T Torishima R Nakashima H | 2004 | Endoscopy2004，36，3： | 1 |
| 14 | Saline-assisted endoscopic resection of rectal carcinoids:Cap aspiration method versus simple snare resection显示文摘 | Nagai T Torishima R Nakashima H | 2004 | Endoscopy2004，36，3： | 1 |
| 15 | Salineassisted endoscopic resection of rectal carcinoids : cap aspiration method versus simple snare resection 显示文摘 | Nagai T Torishima R Nakashima H | 2004 | Endoscopy2004，36，3： | 1 |
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