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| 1 | Anti-inflammatory activity of probiotic Bifidobacterium: Enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells显示文摘AIM: To determine the anti-inflammatory activity of probiotic Bifidobacteria in Bifidobacteria-fermented milk (BFM) which is effective against active ulcerative colitis (UC) and exacerbations of UC, and to explore the immunoregulatory mechanisms. METHODS: Peripheral blood mononuclear cells (PBMNC) from UC patients or HT-29 cells were co-cultured with heat-killed probiotic bacteria or culture supernatant of Bifidobacterium breve strain Yakult (BbrY) or Bifidobacterium bifidum strain Yakult (BbiY) to estimate the amount of IL-10 or IL-8 secreted. RESULTS: Both strains of probiotic Bifidobacteria contained in the BFM induced IL-10 production in PBMNC from UC patients, though BbrY was more effective than BbiY. Conditioned medium (CM) and DNA of both strains inhibited IL-8 secretion in HT-29 cells stimulated with TNF-α, whereas no such effect was observed with heat- killed bacteria. The inhibitory effect of CM derived from BbiY was greater than that of CM derived from BbrY. DNAs of the two strains had a comparable inhibitory activity against the secretion of IL-8. CM of BbiY induced a repression of IL-8 gene expression with a higher expression of IκB-ζ mRNA 4 h after culture of HT-29 cells compared to that in the absence of CM.CONCLUSION: Probiotic Bifidobacterium strains in BFM enhance IL-10 production in PBMNC and inhibit IL-8 secretion in intestinal epithelial cells, suggesting that BFM has anti-inflammatory effects against ulcerative colitis. | Akemi Imaoka Tatsuichiro Shima Kimitoshi Kato Shigeaki Mizuno Toshiki Uehara Satoshi Matsumoto Hiromi Setoyama Taeko Hara Yoshinori Umesaki | 2008 | World Journal of Gastroenterology2008，14，16： | 37 |
| 2 | Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C显示文摘AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse(ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage(β = 0.1865, P < 0.0001) and hyaluronic acid levels(β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated significantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index(BMI)(β =-0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels(β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage(β = 0.2921, P = 0.0044) and hyaluronic acid levels(β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage. | Toru Nishikawa Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Mizuno Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Yuka Takagawa Masashi Ohki Naohiro Ichino Keisuke Osakabe Kentaro Yoshioka | 2014 | World Journal of Gastroenterology2014，20，5： | 7 |
| 3 | Endoscopic submucosal dissection for early esophageal neoplasms using the stag beetle knife显示文摘AIM To determine short-and long-term outcomes of endoscopic submucosal dissection(ESD) using the stag beetle(SB) knife, a scissor-shaped device.METHODS Seventy consecutive patients with 96 early esophageal neoplasms, who underwent ESD using a SB knife at Kure Medical Center and Chugoku Cancer Center, Japan, between April 2010 and August 2016, were retrospectively evaluated. Clinicopathological characteristics of lesions and procedural adverse events were assessed. Therapeutic success was evaluated on the basis of en bloc, histologically complete, and curative or non-curative resection rates. Overall and tumor-specific survival, local or distant recurrence, and 3-and 5-year cumulative overall metachronous cancer rates were also assessed.RESULTS Eligible patients had dysplasia/intraepithelial neoplasia(22%) or early cancers(squamous cell carcinoma, 78%). The median procedural time was 60 min and on average, the lesions measured 24 mm in diameter, yielding 33-mm tissue defects. The en bloc resection rate was 100%, with 95% and 81% of dissections deemed histologically complete and curative, respectively. All procedures were completed without accidental incisions/perforations or delayed bleeding. During follow-up(mean, 35 ± 23 mo), no local recurrences or metastases were observed. The 3-and 5-year survival rates were 83% and 70%, respectively, with corresponding rates of 85% and 75% for curative resections and 74% and 49% for noncurative resections. The 3-and 5-year cumulative rates of metachronous cancer in the patients with curative resections were 14% and 26%, respectively.CONCLUSION ESD procedures using the SB knife are feasible, safe, and effective for treating early esophageal neoplasms, yielding favorable short-and long-term outcomes. | Toshio Kuwai Toshiki Yamaguchi Hiroki Imagawa Ryoichi Miura Yuki Sumida Takeshi Takasago Yuki Miyasako Tomoyuki Nishimura Sumio Iio Atsushi Yamaguchi Hirotaka Kouno Hiroshi Kohno Sauid Ishaq | 2018 | World Journal of Gastroenterology2018，24，15： | 7 |
| 4 | Lymphomatous involvement of gastrointestinal tract: Evaluation by positron emission tomography with ^(18)F-fluorodeoxyglucose显示文摘AIM: To demonstrate the 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) findings in patients with non-Hodgkin's lymphoma (NHL) involving the gastrointestinal (GI) tract and the clinical utility of modality despite of the known normal uptake of FDG in the GI tract.METHODS: Thirty-three patients with biopsy-proven gastrointestinal NHL who had undergone FDG-PET scan were included. All the patients were injected with 10-15 mCi FDG and scanned approximately 60 min later with a CTI/Siemens HR (+) PET scanner. PET scans were reviewed and the maximum standard uptake value (SUVmax) of the lesions was measured before and after the treatment,if data were available and compared with histologic diagnoses.RESULTS: Twenty-five patients had a high-grade lymphoma and eight had a low-grade lymphoma. The stomach was the most common site of the involvement (20 patients). In high-grade lymphoma, PET showed focal nodular or diffuse hypermetabolic activity. The average SUVmax±SD was 11.58±5.83. After the therapy,the patients whose biopsies showed no evidence of lymphoma had a lower uptake without focal lesions.The SUVmax±SD decreased from 11.58±5.83 to 2.21±0.78. In patients whose post-treatment biopsies showed lymphoma, the SUVmax±SD was 9.42±6.27. Low-grade follicular lymphomas of the colon and stomach showed diffuse hypermetabolic activity in the bowel wall (SUVmax 8.2 and 10.3, respectively). The SUVmax was 2.02-3.8 (mean 3.02) in the stomach lesions of patients with MALT lymphoma.CONCLUSION: 18F-FDG PET contributes to the diagnosis of high-grade gastrointestinal non-Hodgkin's lymphoma,even when there is the normal background FDG activity. Furthermore, the SUV plays a role in evaluating treatment response. Low-grade NHL demonstrates FDG uptake but at a lesser intensity than seen in high-grade NHL. | Sith Phongkitkarun Vithya Varavithya Toshiki Kazama Silvana C Faria Martha V Mar Donald A Podoloff Homer A Macapinlac | 2005 | World Journal of Gastroenterology2005，11，46： | 6 |
| 5 | 东日本铁路公司的环保措施显示文摘介绍了东日本铁路公司生态委员会自成立以来所制定的环保目标和具体的行动计划以及已取得的一些成就。 | Shinichiro Kanata Toshiki Saito 郑陵 | 1998 | 中国铁路1998，，6： | 6 |
| 6 | En bloc pancreaticoduodenectomy and right hemicolectomy for locally advanced right-sided colon cancer显示文摘AIM To assess the usefulness of en bloc right hemicolectomy with pancreaticoduodenectomy(RHCPD) for locally advanced right-sided colon cancer(LARCC).METHODS We retrospectively reviewed the database of Saitama Medical Center, Jichi Medical University, between January 2009 and December 2016. During this time, 299 patients underwent radical right hemicolectomy for right-sided colon cancer. Among them, 5 underwent RHCPD for LARCC with tumor infiltration to adjacent organs. Preoperative computed tomography(CT) was routinely performed to evaluate local tumor infiltration into adjacent organs. During the operation, we evaluated the resectability and the amount of infiltration into the adjacent organs without dissecting the adherent organs from the cancer. When we confirmed that radical resection was feasible and could lead to R0 resection, we performed RHCPD. The clinical data were carefully reviewed, and the demographic variables, intraoperative data, and postoperative parameters were recorded.RESULTS The median age of the 5 patients who underwent RHCPD for LARCC was 70 years. The tumors were located in the ascending colon(three patients) and transverse colon(two patients). Preoperative CT revealed infiltration of the tumor into the duodenum in all patients, the pancreas in four patients, the superior mesenteric vein(SMV) in two patients, and tumor thrombosis in the SMV in one patient. We performed RHCPD plus SMV resection in three patients. Major postoperative complications occurred in 3 patients(60%) as pancreatic fistula(grade B and grade C, according to International Study Group on Pancreatic Fistula Definition) and delayed gastric empty. None of the patients died during their hospital stay. A histological examination confirmed malignant infiltration into the duodenum and/or pancreas in 4 patients(80%), and no patients showed any malignant infiltration into the SMV. Two patients were histologically confirmed to have tumor thrombosis in the SMV. All of the tumors had clear resection margins(R0). The median follow-up time was 77 mo. During this period, two patients with tumor thrombosis died from liver metastasis. The overall survival rates were 80% at 1 year and 60% at 5 years. All patients with node-negative status(n = 2) survived for more than seven years.CONCLUSION This study showed that the long-term survival is possible for patients with LARCC if RHCPD is performed successfully, particularly in those with node-negative status. | Yuji Kaneda Hiroshi Noda Yuhei Endo Nao Kakizawa Kosuke Ichida Fumiaki Watanabe Takaharu Kato Yasuyuki Miyakura Koichi Suzuki Toshiki Rikiyama | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 7 | Rescue of white egg 1 mutant by introduction of the wildtype Bombyx kynurenine 3-monooxygenase gene显示文摘在蚕,白鸡蛋 1 (w-1 ) 异种,被白眼睛和白鸡蛋描绘,在 Bombyx kynurenine 3-monooxygenase (KMO ) 是缺乏的活动。Toinvestigate w-1 异种显型是否被介绍野类型的 KMO 基因救,我们在细胞质的肌动朊基因倡导者(A3KMO ) 或本国的 KMO 基因倡导者(KKMO ) 的控制下面与野类型的 Bombyx KMO 基因构造了转基因的蚕。我们与 KKMO 构造与 A3KMO 和一根线创造了二根转基因的线。在这些线的成年人的眼睛是棕色的,并且转基因的女性生的鸡蛋也是棕色的。Reversetranscription 聚合酶链反应(RT-PCR ) 分析证明 A3KMO 蚕线在中间勇气的、胖身体表示了抄本,并且肾小体小管。KKMO 线仅仅在胖身体表示了抄本并且肾小体小管。在转基因的线的眼睛和卵色的紧张与 KMO 表示水平成正比。有趣地,有 A3KMO 构造的转基因的幼虫有轻褐幼虫的表皮,而是 KKMO 线不。这些结果显示野类型的 KMO 基因能作为标记基因被使用视觉上屏蔽转基因的蚕。 | GUO-XING QUAN ISAO KOBAYASHI KATSURA KOJIMA KEIRO UCHINO TOSHIO KANDA HIDEKI SEZUTSU TORU SHIMADA TOSHIKI TAMURA | 2007 | Insect Science2007，14，2： | 4 |
| 8 | 利用振幅衰减和脉冲增宽的地震衰减层析成像法显示文摘本文论述了两种基于射线的地震衰减层析成像法。其中一种是利用振幅衰减;另一种是利用P波初至的脉冲增宽。在第一种层析成像法中,速度结构(例如:传播损耗、绕射、射线聚焦)所引起的振幅变化要在层析成像分析之前消除。并要估算频率在传播过程中的变化以及考虑它对振幅衰减的影响。第二种层析成像法是以粘弹性介质中波的脉冲增宽为基础的。脉冲宽度(或增时)和旅行时之间的关系被称作增时原理(Gladwin和Stacey,1974)。我们在某矿区应用这二种方法对现场的岩石作了试验。通过衰减层析成像法清晰地呈现出该矿区的断层和裂缝带。研究结果与现场地质形态以及实验室试验结果极为一致。 | Toshiki Watanabe 王芑谋 | 1994 | 石油物探译丛1994，，3： | 3 |
| 9 | Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats显示文摘 | Shimon Amemiya Tatsushi Kamiya Chikako Nito Toshiki Inaba Kengo Kato Masayuki Ueda Kuniko Shimazaki Yasuo Katayama | 2005 | European Journal of Pharmacology2005，，2： | 3 |
| 10 | Experimental Analysis of Flow Structure in Contra-Rotating Axial Flow Pump Designed with Different Rotational Speed Concept显示文摘As a high specific speed pump, the contra-rotating axial flow pump distinguishes itself in a rear rotor rotating in the opposite direction of the front rotor, which remarkably contributes to the energy conversion, the reduction of the pump size, better hydraulic and cavitation performances. However, with two rotors rotating reversely, the significant interaction between blade rows was observed in our prototype contra-rotating rotors, which highly affected the pump performance compared with the conventional axial flow pumps. Consequently, a new type of rear rotor was designed by the rotational speed optimization methodology with some additional considerations, aiming at better cavitation performance, the reduction of blade rows interaction and the secondary flow suppression. The new rear rotor showed a satisfactory performance at the design flow rate but an unfavorable positive slope of the head-flow rate curve in the partial flow rate range less than 40% of the design flow rate, which should be avoided for the reliability of pump-pipe systems. In the present research, to understand the internal flow field of new rear rotor and its relation to the performances at the partial flow rates, the velocity distributions at the inlets and outlets of the rotors are firstly investigated. Then, the boundary layer flows on rotor surfaces, which clearly reflect the secondary flow inside the rotors, are analyzed through the limiting streamline observations using the multi-color oil-film method. Finally, the unsteady numerical simulations are carried out to understand the complicated internal flow structures in the rotors. | Linlin Cao Satoshi Watanabe Toshiki Imanishi Hiroaki Yoshimura Akinori Furukawa | 2013 | Journal of Thermal Science2013，22，4： | 3 |
| 11 | Self-calibration and Compensation of Setting Errors for Surface Profile Measurement of a Microstructured Roll Workpiece显示文摘Microstructured roll workpieces have been widely used as functional components in the precision industries.Current researches on quality control have focused on surface profile measurement of microstructured roll workpieces,and types of measurement systems and measurement methods have been developed.However,low measurement efficiency and low measurement accuracy caused by setting errors are the common disadvantages for surface profile measurement of microstructured roll workpieces.In order to shorten the measurement time and enhance the measurement accuracy,a method for self-calibration and compensation of setting errors is proposed for surface profile measurement of microstructured roll workpieces.A measurement system is constructed for the measurement,in which a precision spindle is employed to rotate the roll workpiece and an air-bearing displacement sensor with a micro-stylus probe is employed to scan the microstructured surface of the roll workpiece.The resolution of the displacement sensor is0.14 nm and that of the rotary encoder of the spindle was 0.15.Geometrical and mathematical models are established for analyzing the influences of the setting errors of the roll workpiece and the displacement sensor with respect to the axis of the spindle,including the eccentric error of the roll workpiece,the offset error of the sensor axis and the zero point error of the sensor output.Measurement experiments are carried out on a roll workpiece on which periodic microstructures are a period of 133μm along the circumferential direction.Experimental results demonstrate the feasibility of the self-compensation method.The proposed method can be used to detect and compensate the setting errors without using any additional accurate artifact. | GAO Wei XU Bin TAKEISHI Toshiki SHIMIZU Yuki ITO So | 2014 | Chinese Journal of Mechanical Engineering2014，27，1： | 3 |
| 12 | Paradoxical reduction of cerebral blood flow after acetazolamide loading:a hemodynamic and metabolic study with ^(15)O PET显示文摘Paradoxical reduction of cerebral blood flow(CBF)after administration of the vasodilator acetazolamide is the most severe stage of cerebrovascular reactivity failure and is often associated with an increased oxygen extraction fraction(OEF).In this study,we aimed to reveal the mechanism underlying this phenomenon by focusing on the ratio of CBF to cerebral blood volume(CBV)as a marker of regional cerebral perfusion pressure(CPP).In 37patients with unilateral internal carotid or middle cerebral arterial(MCA)steno-occlusive disease and8 normal controls,the baseline CBF(CBF_b),CBV,OEF,cerebral oxygen metabolic rate(CMRO_2),and CBF after acetazolamide loading in the anterior and posterior MCA territories were measured by^(15)O positron emission tomography.Paradoxical CBF_b reduction was found in 28 of 74 regions(18of 37 patients)in the ipsilateral hemisphere.High CBF_b(>47.6 mL/100 mL/min,n=7)was associated with normal CBF_b/CBV,increased CBV,decreased OEF,and normal CMRO_2.Low CBF_b(<31.8 mL/100mL/min,n=9)was associated with decreased CBF_b/CBV,increased CBV,increased OEF,and decreased CMRO_2.These findings demonstrated that paradoxical CBF reduction is not always associated with reduction of CPP,but partly includes highCBF_b regions with normal CPP,which has not been described in previous studies. | Tadashi Watabe Eku Shimosegawa Hiroki Kato Kayako Isohashi Mana Ishibashi Mitsuaki Tatsumi Kazuo Kitagawa Toshiyuki Fujinaka Toshiki Yoshimine Jun Hatazawa | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 13 | Enhancing soil water holding capacity and provision of a potassium source via optimization of the pyrolysis of bamboo biochar显示文摘Rapid expansion of cultivated bamboo negatively impacts on biodiversity and soil microbial community.As such,it is important to properly manage and use bamboo to prevent and control such issues.This study focuses on optimizing pyrolysis conditions to produce bamboo biochar for agricultural soil amendment,particularly soil potassium(K)and water holding capacity.Bamboo chips were pyrolyzed under nitrogen gas at 400,600,and 800℃ for 1 and 2 h of retention.A total of six biochar products were created:400-1(i.e.,400℃ in 1 h),400-2,600-1,600-2,800-1,and 800-2.The 600℃ bamboo biochar products were observed to have the greatest potential in increasing soil K and water holding capacity.The 600-1 product had the highest potassium content(4.87%),with a water holding capacity of 3.73 g g^(−1),while the 600-2 product had the second-highest potassium content(4.13%)and the highest water holding capacity(4.21 g g^(−1))and cation exchange capacity.The K release in 600℃ products was larger and slower than that of the 400℃ and 800℃ products,respectively.The results also indicated that the physicochemical characteristics of bamboo biochar,such as yield,pH,surface area,water holding capacity,and K content,were significantly impacted by temperature,retention time,or a combination of these parameters.The outcomes from this study are a valuable reference for bamboo biochar production targeting agricultural soil amendment,particularly when it is directed at increasing soil K and water holding capacity. | Tran Thi Thu Hien Toshiki Tsubota Tomoyuki Taniguchi Yoshiyuki Shinogi | 2021 | Biochar2021，3，1： | 3 |
| 14 | Pancreaticobiliary maljunction and carcinogenesis to biliary and pancreatic malignancy显示文摘 | Takahiko Funabiki Toshiki Matsubara Shuichi Miyakawa Shin Ishihara | 2009 | Langenbeck’s Archives of Surgery2009，，1： | 3 |
| 15 | A case of eosinophilic cholangitis:Imaging findings ofcontrast-enhanced ultrasonography, cholangioscopy, andintraductal ultrasonography显示文摘A 38-year-old woman was referred to our institution due to epigastralgia. She presented with obstructive jaundice and eosinophilia. Endoscopic retrograde cholangiopancreatography showed diffuse narrowing from the distal common bile duct to the bifurcation of the hepatic ducts. An endoscopic plastic biliary stent was inserted; the specimen obtained from the common bile duct wall revealed dense infiltration by eosinophils. Treatment was started with prednisolone 60 mg daily. The patient's biliary stenosis and eosinophilia gradually improved. Eosinophilic infiltration in the lungs or stomach is relatively common, but it is rare in the common bile duct. Most of the reported cases of eosinophilic cholangitis presented with eosinophilia; our patient's eosinophil count was over 1000/mm3. Since our patient had allergies to pollen and house dust, a relationship between the allergies and the eosinophilic cholangitis was suspected, but no cause was identified. | Naoki Matsumoto Kiyoshi Yokoyama Kazuhiko Nakai Toshiki Yamamoto Takeshi Otani Masahiro Ogawa Naohide Tanaka Ariyoshi Iwasaki Yasuyuki Arakawa Masahiko Sugitani | 2007 | World Journal of Gastroenterology2007，13，13： | 3 |
| 16 | Design of ionic liquids as liquid desiccant for an air conditioning system显示文摘Suitable control of the humidity can contribute to electric energy savings. However, the present dehumidification system has many weak points. The liquid desiccant air-conditioning system has recently gained growing interest from the stand point of reducing energy consumption during dehumidification. In order to find the appropriate ionic liquids(ILs) as a desiccant for the liquid desiccant air-conditioner system, we conducted a systematic evaluation of the humidification capability of 16 types of ILs. Among the tested ILs, tributyl(methyl)phosphonium dimethyl phosphate([P4441][DMPO_4]) exhibited the best dehumidification capacity and had a less corrosive effect on four types of metals as possible piping materials. It should be noted that this [P_(4441)][DMPO_4] has a very stable nature and produced no odor while conducting the experiment and storing for over 1 year at room temperature under ambient conditions. Furthermore, it was revealed that a 77%(w/w) aqueous solution of [P4441][DMPO_4] worked as an efficient desiccant liquid for the liquid desiccant air-conditioner system. | Haruki Watanabe Takuro Komura Ryo Matsumoto Kenta Ito Hiroshi Nakayama Toshiki Nokami Toshiyuki Itoh | 2019 | Green Energy & Environment2019，4，2： | 3 |
| 17 | 新干线车辆高速运行时滚动噪声和空气动力噪声对车辆下部总噪声的贡献显示文摘为降低新干线列车发出的噪声,首先试图定量估算滚动噪声的贡献。随后,通过比较测量的噪声与分析估算的滚动噪声,确定空气动力噪声对车辆下部总噪声的贡献。研究结果显示,当车辆高速运行时,轨道附近测点处空气动力噪声对车辆下部总噪声的贡献比滚动噪声大。 | Toshiki KITAGAWA 周贤全 | 2015 | 国外铁道车辆2015，0，2： | 3 |
| 18 | Biological efficacy of perpendicular type-I collagen protruded from TiO_(2)-nanotubes显示文摘The aim of this study was to evaluate the biological efficacy of a unique perpendicular protrusion of type-I collagen(Col-I)from TiO2 nanotubes(NT-EPF surface).We hypothesized that the NT-EPF surface would play bifunctional roles in stimulating plateletmediated fibroblast recruitment and anchoring fibroblast-derived Col-I to form a perpendicular collagen assembly,mimicking the connective tissue attachment around natural teeth for the long-term maintenance of dental implants.Ti surface modification was accomplished in two steps.First,TiO2 nanotubes(NT)array was fabricated via anodization.Diameters and depths of NTs were controlled by applied voltage and duration.Subsequently,an electrophoretic fusion(EPF)method was applied to fuse Col-I into nanotube arrays in a perpendicular fashion.Surface wettability was assessed by contact angle measurement.The bioactivity of modified TiO2 surfaces was evaluated in terms of NIH3T3 fibroblast attachment,platelet activation,and collagen extension.Early attachment,aggregation,and activation of platelets as well as release of platelet-related growth factors were demonstrated on NTEPF surfaces.Platelet-mediated NIH3T3 cells migration toward NT-EPF was significantly increased and the attached cells showed a typical fibrous morphology with elongated spindle shape.A direct linkage between pseudopod-like processes of fibroblasts to NTEPF surfaces was observed.Furthermore,the engineered EPF collagen protrusion linked with cell-derived collagen in a perpendicular fashion.Within the limitation of this in vitro study,the TiO2 nanotube with perpendicular Col-I surface(NT-EPF)promoted better cell attachment,induced a strong platelet activation which suggested the ability to create a more robust soft tissue seal. | Chia-Yu Chen David M.Kim Cliff Lee John Da Silva Shigemi Nagai Toshiki Nojiri Masazumi Nagai | 2020 | International Journal of Oral Science2020，12，4： | 3 |
| 19 | Oral supplementation of branched-chain amino acids reduces early recurrence after hepatic resection in patients with hepatocellular carcinoma: a prospective study显示文摘 | Kengo Ichikawa Takehiro Okabayashi Hiromichi Maeda Tsutomu Namikawa Tatsuo Iiyama Takeki Sugimoto Michiya Kobayashi Toshiki Mimura Kazuhiro Hanazaki | 2013 | Surgery Today2013，，7： | 2 |
| 20 | Prognostic impact of lymphovascular invasion compared with that of visceral pleural invasion in patients with pN0 non–small-cell lung cancer and a tumor diameter of 2 cm or smaller显示文摘 | Hiroyuki Tao Tatsuro Hayashi Fumiho Sano Akihiro Takahagi Toshiki Tanaka Eisuke Matsuda Kazunori Okabe | 2013 | Journal of Surgical Research2013，，： | 2 |
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