| 4 | 阿片样肽类的微离子透入对猫小脑浦肯野氏细胞的作用(英文)显示文摘AIM:The purpose of the present study was to examine the effects of microiontophoretically-applied opioid pep-tides on Purkinje cell of the cerebellum. METHODS: The effects of microiontophoretically-applied morphine, leucine-enkephalin (Leu-Enk),methionine-enkephalin (Met-Enk), and dynorphin 1-13 (Dyn) on the spontaneous discharge of Purkinje cells in the cerebellum of the anesthetized cat were examined.RESULTS:Microion-tophoretic applications of Leu-Enk and morphine produced inhibitory and excitatory responses, respectively in Purkinje cells.Application of both morphine and Leu-Enk induced dose-dependent responses. The excitatory responses were antagonized by naloxone, whereas the inhibitory responses were not. Bicuculline,a GABA-A antagonist, completely abolished both the Leu-Enk- and morphine-induced-inhibitory responses.Iontophoretic application of Met-Enk and dyn produced inhibitory responses only. Met-enk- and dyn-induced inhibition was antagonized by naloxone. CONCLUSION:In Purkinje cell activity, | Kyoji TAGUCHI Kenji ABE Touichiro CHYUMA Masatoshi KATO Toshiro SHIGENAGA Kazuki KUSHIDA Toshiyuki CHIKUMA | 2000 | Acta Pharmacologica Sinica2000，21，10： | 0 |
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