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	题名	作者	年代	出处	被引量
1	Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis.	Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic	2019	Cellular & Molecular Immunology2019，16，2：	2
2	The role of microglia in the healthy brain显示文摘	Tremblay ME Stevens B Sierra A	2011	The Journal of neuroscience:the official journal of the Society for Neuroscience2011，31，16：	1
3	The role of microglia in the healthy brain显示文摘	Tremblay ME Stevens B Sierra A	2011	J Neurosci2011，31，16：	1
4	Microglial in-teractions with synapses are modulated by visual experience显示文摘	Tremblay ME Lowery RL Majewska AK	2010	PLoS Biol2010，8，00：	1
5	The role of microglia in thehealthy brain显示文摘	Tremblay Me Stevens B Sierra A	2011	J Neurosci2011，31，16：	1
6	Systematic review of sedentary behavior and health indicators in school-aged children and youth 显示文摘	Tremblay MS Leblanc AG Kho ME Saunders T J Larouche RC Colley R Goldfield G Gorber SC	2011	Int J Behav Nutr Phys Act2011，8，：	1
7	The role of microglia in the healthy brain显示文摘	Tremblay ME Stevens B Sierra A	2011	J Neurosci2011，31，16：	1
8	Associations of sedentary behavior,sedentary bouts and breaks in sedentary time with cardiometabolic risk in children with a family history of obesity显示文摘	SAUNDERS TJ TREMBLAY MS MATHIEU ME	2013	PLo S One2013，8，79：	1
9	Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression显示文摘	Mazroui R Huot ME Tremblay S	2002	Hum Mol Genet2002，11，24：	1
10	Associations between the fatty acid content of triglyceride,visceral adipose tissue accumulation,and components of the insulin resistance syndrome显示文摘	Despres JP Piche ME	2004	Metabolism2004，53，3：	1
11	The role of mieroglia in the healthy brain显示文摘	Tremblay ME Stevens B Sierra A	2011	J Neurosci2011，31，16：	1
12	Systematic review of sedentary behaviour and health indicators in school-aged children and youth显示文摘	Tremblay MS Leblanc AG Kho ME	2011	Int J Behav Nutr Phys Act2011，8，：	1
13	Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus显示文摘	Tremblay ME Riad M Bouvier D	2007	J Comp Neurol2007，501，5：	1
14	Distinct oxidoresistance phenotypic of human T47D cells transfected by rat glutathione S-transferase Yc expression vectors显示文摘	Lavoie L Tremblay A Mirault ME	1992	J Biol Chem1992，267，6：	1
15	Microglia and synapse: interactions in health and neurodegeneration显示文摘	Siskov6 Z Tremblay ME	2013	Neural Plast2013，2013，42：	1
16	Neuroprotective effects of cystamine in aged parkinsonian mice显示文摘	Tremblay ME Saint-Pierre M Bourhis E	2006	Neurobiol Aging2006，27，6：	1
17	Neuroprotective effects of cystamine in aged parkinsonian mice 显示文摘	Tremblay ME Saint-Pierre M Bourhis E	2006	Neurobiol Aging2006，27，6：	1
18	Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain显示文摘	Bouvier D Corera AT Tremblay ME	2008	J Neurochem2008，106，2：	1
19	Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain显示文摘	Bouvier D Corera AT Tremblay ME	2008	J Neurochem2008，106，2：	1
20	Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus显示文摘	Tremblay ME Riad M Bouvier D	2007	J Comp Neurol2007，501，5：	1

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