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| 1 | A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid 'Harmine'显示文摘Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring.Harmine has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic properties.It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant effect.Harmine prevents bone loss by suppressing osteoclastogenesis.The current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases. | K Patel M Gadewar R Tripathi SK Prasad Dinesh Kumar Patel | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 17 |
| 2 | Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel,flavopiridol,and 5-fluorouracil显示文摘瞄准:有 docetaxel, flavopiridol,或 5 氟尿嘧啶(5-FU ) 的稳固的肿瘤的临床的治疗经常遇到不受欢迎的副作用和药抵抗。在 modulating chemosensitivity 并且更好与 docetaxel, flavopiridol,或 5-FU 评估联合治疗的潜在的角色的目的理解他们怎么可能临床上被使用的这研究。方法:HCT116 结肠癌房间在几不同行政时间表在试管内与 docetaxel, flavopiridol,和 5-FU 被对待,顺序或同时。房间幸存被 MTT 试金测量。caspase-3 的活动被 caspase-3 试金决定,软琼脂殖民地试金被用来在软琼脂测试 HCT116 房间的菌落形成。我们也建立了异种皮移植模型扩大在试管内观察到一个在活体内系统。结果:当人的结肠癌 HCT116 房间为 flavopiridol 为另一 24 h 为 24 h 和 5-FU 跟随的 1 h 与 docetaxel 被对待时,最大的细胞毒性被发现。这顺序的联合治疗不仅与另外的联合治疗相比更强烈禁止肿瘤细胞生长而且显著地在软琼脂减少菌落形成并且扩充 HCT116 细胞的 apoptosis。docetaxel 定序以后由 flavopiridol 跟随了 1 h,以后在异种皮移植模型由 5-FU 跟随了 24 h,也导致了推迟的肿瘤生长和更高的幸存率。结论:当把 docetaxel 与 flavopiridol 和 5-FU 相结合时,这些结果强调一张行政时间表的重要性,提供对它在临床的试用的发展的基本原理解释。 | Jun GUO An-wu ZHOU Yu-cai FW Udit N VERMA Debu TRIPATHY Eugene P FRENKEL Carlos R BECERRA | 2006 | Acta Pharmacologica Sinica2006，27，10： | 4 |
| 3 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 4 | The PPAR gamma agonist Pioglitazone improves anatomical and locomotor recovery after rodent spinal cord injury显示文摘 | McTigue DM Tripathi R Wei P | 2007 | Exp Neurol2007，205，2： | 1 |
| 5 | Salmonella pathogenicity island 2 influences both systemic Salmonellosis and Salmonella in duced enteritisincalves显示文摘 | Bispham J Tripathi B N Watson P R | 2001 | Infection and Immunity2001，69，： | 1 |
| 6 | Poly(butylene terephthalate) nanocomposites prepared by in-situ polymerization显示文摘 | Tripathy A R Burgaz E Kukureka S N | 2003 | Macromolecules2003，36，23： | 1 |
| 7 | RXLR effector reservoir in two phytophthora species is dominated by a single rapidly evolving superfamily with more than 700 members显示文摘 | Jiang R H Tripathy S Govers F | 2008 | Proceedings of the National Academy of Sciences of the United States of America2008，105，12： | 1 |
| 8 | Glil protein reguates ti S-phase checkpoint in tumor cells via Bid protein, and its inhibitior sensitizes to DNA topoisomerase I inhibitors显示文摘 | Tripathi K Mani C Barnett R | 2014 | J Biol Chem2014，289，31： | 1 |
| 9 | Targeting the cyclin-binding groove site to inhibit the catalytic activity of CDK2/ cyclin A complex using p27KIPl-derived peptidomimetic inhibitors 显示文摘 | Karthiga A Tripathi SK Shanmugam R | 2015 | J Chem Biol2015，8，1： | 1 |
| 10 | CXCR7 mediated Gi- alpha independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells 显示文摘 | Kumar R Tripathi V Ahmad M | 2012 | Cell Immunol2012，272，2： | 1 |
| 11 | Comparativestudy of carbon nanotube dispersion using surfactants 显示文摘 | Rastogi R Kaushal R Tripathi S K | 2008 | Journal of Colloid and Interface Science2008，328，2： | 1 |
| 12 | Photon induced positron annihilation spectroscopy:a nondestructive method for assay of defects in large engineering materials显示文摘 | Pujari P K Sudarshan K Tripathi R | 2012 | Nuclear Instruments and Methods in Physics Research2012，270，： | 1 |
| 13 | Decomposition of fine roots of Pinus kesiya and turnover of organic matter,N and P of coarse and fine pine roots and herbaceous roots and rhizomes in subtropical pine forests stands of different ages 显示文摘 | John B Pandey H N Tripathi R S | 2002 | Biology and Fertility of Soils2002，35，4： | 1 |
| 14 | Experimental performance of a liquid desiccant dehumidification system under tropical climates显示文摘 | JAIN S TRIPATHI S DAS R S | 2011 | Energy Conversion and Management2011，52，： | 1 |
| 15 | Deep venous valve reconstruction for non-healing leg ulcers: techniques and results 显示文摘 | Tripathi R Sieunarine K Abbas M | 2004 | ANZ J Surg2004，74，12： | 1 |
| 16 | Production of astaxanthin in Haermatococcus pluvialis cultured in various media 显示文摘 | Sarada R Ramachandra R | 1999 | Bioresour Technol1999，68，： | 1 |
| 17 | Chemical processing of a low grade molybdenite concentrate to recover molybdenum 显示文摘 | Tripathy P K Rakhasia R H | 2005 | Mineral Processing & Extractive Metallurgy2005，，： | 1 |
| 18 | Characterization of iron-bearing minerals in Giril lignite from Rajasthan and study of their decomposition during combustion using ^57Fe Moessbauer spectroscopy显示文摘 | Verma H C Tripathi R P | 2000 | Fuel2000，79，6： | 1 |
| 19 | ITS-RFLP fingerprinting and molecular marker for detection of Fusarium oxysporum f sp ciceris显示文摘 | Dubey S C Tripathi A Singh S R | 2010 | Folia Microbiol (Praha)2010，55，6： | 1 |
| 20 | Application of the Ponseti principle for deformitv correction in neglected and relapsed club foot using the Ilizarov fixator显示文摘 | Tripathy SK Saini R Sudes P | | 0，，01： | 1 |
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