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| 1 | 中国部分绵羊群体形态及生态特征多元统计分析显示文摘分别以绵羊群体为研究对象直接进行Q型系统聚类,与以群体的数量指标为研究对象,构造主成分值,再以主成分为研究对象进行R型系统聚类,均可在一定程度上揭示群体间的遗传分化,得到了与中国绵羊亲缘系统既有知识相吻合的结果。以群体的数量指标为研究对象直接进行Q型系统聚类分析,可以发现海拔与年降水量是影响绵羊分布的两个重要指标,这与以群体为研究对象进行Q型系统聚类及与以群体的指标为研究对象进行的主成分分析所提供的信息基本一致。生态因子是绵羊品种区域分类的一个重要指标。 | 孙伟 常洪 任战军 杨章平 耿荣庆 Tsunoda Kenji | 2004 | 中国农业科学2004，37，2： | 18 |
| 2 | Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus显示文摘Cardiovascular(CV) complications are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis being a common risk factor for prospective crisis of coronary artery diseases and/or cerebral infarction in DM subjects. From another point of view, asymmetric dimethylarginine(ADMA) has been established as an inhibitor of endogenous nitric oxide synthesis and the relationship between ADMA and arteriosclerosis has been reported. In our study with 87 type 2 DM(T2DM) patients, we have examined whether ADMA and other CV risk factors are the useful predictors of DMCV complications. After the measurement of the respective CV risk factors, we have followed the enrolled T2 DM patients for 5 years. We have finally analyzed 77 patients. DMCV complications developed in 15 cases newly within 5 years, and 4 cases recurred. The concentrations of ADMA in plasma were markedly more elevated in 19 DM patients with CV complications than in 58 DM patients without CV complications. Urinary albumin(U-Alb), mean intimal-medial thickness(IMT) and ankle brachial index(ABI) were also higher in patients with CV complications. Multiple regression analyses showed that U-Alb had an influence on the high level of ADMA(standardized β = 6.59, P = 0.00014) independently of age, systolic BP, fibrinogen, mean IMT, plaque score, and ABI. The review indicates what is presently known regarding plasma ADMA that might be a new and meaningful biomarker of CV complications in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Yuzo Yano Taku Tsunoda Takashi Ikawa Toshihiro Matsuo Fumihiro Ochi Yoshiki Kusunoki Masaru Tokuda Tomoyuki Katsuno Tomoya Hamaguchi Jun-ichiro Miyagawa Mitsuyoshi Namba | 2015 | World Journal of Experimental Medicine2015，5，2： | 16 |
| 3 | 绵羊血钾与其他13种蛋白基因座位遗传共适应的分析显示文摘为探讨多座位基因型非随机分布的形成机制 ,进行遗传共适应和连锁不平衡检测 ,以湖羊血钾和其它 13个编码结构蛋白酶座位为研究对象 ,采用显隐性—显隐性和显隐性—共显性两种数据模型 ,进行独立性测检。结果表明 :绵羊血钾遗传分化程度在其高低的各自特定范围内受到多种因素的影响 ;在显隐性—显隐性模型中 ,未发现血钾与其他座位有相关性 ;在显隐性—共显性模型中 ,发现Ke与Tf座位存在极显著的相关性 ,Tf座位不处于Hardy Weinberg平衡状态 。 | 孙伟 常洪 扬章平 耿荣庆 Tsunoda K | 2002 | 南京农业大学学报2002，25，4： | 11 |
| 4 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 5 | Safety and utility of capsule endoscopy for infants and young children显示文摘AIM:To assess the safety and utility of capsule endoscopy(CE)for children who are unable to swallow the capsule endoscope.METHODS:The medical records of all of the children who underwent CE between 2010 and 2012 were retrospectively reviewed.The patients were divided into 2groups:group A included patients who were unable to swallow the capsule endoscope,and group B included patients who were able to swallow it.For the patients who were unable to swallow the capsule endoscope,it was placed in the duodenum endoscopically.The small bowel transit time,endoscopic diagnosis and complications of the 2 groups were compared.RESULTS:During the study period,28 CE procedures were performed in 26 patients.Group A included 11patients with a median age of 2 years(range 10 mo-9years),and group B included 15 patients with a median age of 12 years(range 8 years-16 years).The lightest child in the study weighed 7.9 kg.The detection rates did not differ between the 2 groups.The median small bowel transit time was 401 min(range 264-734 min)in group A and 227 min(range 56-512 min)in group B(P=0.0078).No serious complications,including capsule retention,occurred.No significant mucosal trauma occurred in the pharynx,esophagus,stomach or duodenum when the capsule was introduced using an endoscope.CONCLUSION:CE is a safe and useful procedure for infants and young children who are unable to swallow the capsule endoscope. | Manari Oikawa-Kawamoto Tsuyoshi Sogo Takeshi Yamaguchi Tomoyuki Tsunoda Takeo Kondo Haruki Komatsu Ayano Inui Tomoo Fujisawa | 2013 | World Journal of Gastroenterology2013，19，45： | 7 |
| 6 | 受精和生精过程中的氧化还原调节显示文摘氧化应激是男性不育的重要原因之一,它可以损害生精细胞、生精过程以及精子功能。最新的氧化还原生物学研究揭示了细胞所产生的活性氧(ROS)的信号作用。虽然羟自由基等高活性氧化剂有大量的有害作用,但由于过氧化氢为中等应激并有膜渗透性,而且只能氧化有限数量的生物分子功能团,所以过氧化氢可以作为一个信号调停者切实发挥作用。氨基酸支链最敏感的氧化部位是半胱氨酸的巯基,这也是一些常见酶参与催化反应的部位。虽然半胱氨酸的巯基化反应性在普通蛋白质中并不高,但一些磷酸酶在催化中心具有高反应性的巯基组,从而可通过细胞外刺激并在一定的环境条件下暂时升高过氧化氢水平而被氧化灭活。相应的,过氧化还原酶有中等的过氧化氢还原活性,而磷酸酶受到保护以免被氧化灭活,能调节过氧化还原酶在普通细胞中的由活性氧介导的信号转导调节作用,这已经受到越来越多的关注。虽然目前我们关于活性氧在男性生殖系统的信号作用知之甚少,但其重要意义正逐渐成为一个焦点问题。因此,本文把睾丸中过氧化氢作为新兴信号的作用加以综述。 | Junichi Fujii Satoshi Tsunoda | 2011 | Asian Journal of Andrology2011，13，3： | 7 |
| 7 | 中亚以东南绵羊群体亲缘血统判别式的研究显示文摘在将中亚以东南绵羊群体划分为“蒙古羊”、“南亚羊”和“欧洲羊”三大集团的既有研究结论的基础上 ,论证了这一广阔地域的血统两个判别式 ;以 10个群体 10个基因座 33个等位基因频率为例对这两个判别式进行验证。根据遗传贴近度的思想确定判别式 2为最理想的判别式。以该式判别一个未知群体的血统是否符合已知的畜牧学逻辑 ,结果肯定判别式 2定义的遗传贴近度是中亚以东南绵羊群体血统判别的可靠依据 ,可以反映湖羊、同羊和云南绵羊的血统育成过程。该式也适用于其它层次的遗传标记。 | 孙伟 常洪 任战军 杨章平 耿荣庆 Tsunoda K. | 2003 | 畜牧兽医学报2003，34，2： | 6 |
| 8 | Randomized controlled trial of bipolar diathermy vs ultrasonic scalpel for closed hemorrhoidectomy显示文摘AIM:To compare hemorrhoidectomy with a bipolar electrothermal device or hemorrhoidectomy using an ultrasonically activated scalpel.METHODS:Sixty patients with grade Ⅲ or Ⅳ hemorrhoids were prospectively randomized to undergo closed hemorrhoidectomy assisted by bipolar diathermy(group 1) or hemorrhoidectomy with the ultrasonic scalpel(group 2).Operative data were recorded,and patients were followed at 1,3,and 6 wk to evaluate complications.Independent assessors were assigned to obtain postoperative pain scores,oral analgesic requirement and satisfaction scores.RESULTS:Reduced intraoperative blood loss median 0.9 mL(95% CI:0.8-3.7) vs 4.6 mL(95% CI:3.8-7.0),P = 0.001 and a short operating time median 16(95% CI:14.6-18.2) min vs 31(95% CI:28.1-35.3) min,P < 0.0001 was observed in group 1 compared with group 2.There was a trend towards lower postoperative pain scores on day 1 group 1 median 2(95% CI:1.8-3.5) vs group 2 median 3(95% CI:2.6-4.2),P = 0.135.Reduced oral analgesic requirement during postoperative 24 h after operation median 1(95% CI:0.4-0.9) tablet vs 1(95% CI:0.9-1.3) tablet,P = 0.006 was observed in group 1 compared with group 2.There was no difference between the two groups in the degree of patient satisfaction or number of postoperative complications.CONCLUSION:Bipolar diathermy hemorrhoidectomy is quick and bloodless and,although as painful as closed hemorrhoidectomy with the ultrasonic scalpel,is associated with a reduced analgesic requirement immediately after operation. | Akira Tsunoda Haruki Sada Takuya Sugimoto Nobuyasu Kano Mariko Kawana Tadanori Sasaki Hideki Hashimoto | 2011 | World Journal of Gastrointestinal Surgery2011，3，10： | 6 |
| 9 | Hepatocyte growth factor, a biomarker of macroangiopathy in diabetes mellitus显示文摘Atherosclerotic involvements are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis(CA) being a common risk-factor for prospective crisis of coronary artery diseases(CAD) and/or cerebral infarction(CI) in DM subjects. From another point of view, several reports have supplied augmenting proof that hepatocyte growth factor(HGF) has a physiopathological part in DM involvements. HGF has been a mesenchymal-derived polyphenic factor which modulates development, motion, and morphosis of diverse cells, and has been regarded as a humor intermediator of epithelial-mesenchymal interplays. The serum concentrations of HGF have been elevated in subjects with CAD and CI, especially during the acute phase of both disturbances. In our study with 89 type 2 DM patients, the association between serum concentrationsof HGF and risk-factors for macrovascular complicationsinclusive of CA were examined. The average of serumHGF levels in the subjects was more elevated than thereference interval. The serum HGF concentrations associated positively with both intimal-media thickness(IMT)(r = 0.24, P = 0.0248) and plaque score(r = 0.27, P =0.0126), indicating a relationship between the elevatedHGF concentrations and advancement of CA involvements. Multivariate statistical analysis accentuated thatserum concentrations of HGF would be associated inde-pendently with IMT(standardized = 0.28, P = 0.0499).The review indicates what is presently known regardingserum HGF might be a new and meaningful biomarkerof macroangiopathy in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Taku Tsunoda Yuzo Yano Tomoyuki Katsuno Tomoya Hamaguchi Jun-Ichiro Miyagawa Mitsuyoshi Namba | 2014 | World Journal of Diabetes2014，5，5： | 5 |
| 10 | Analysis on Temperature Distributions in Single Cell of Polymer Electrolyte Fuel Cell When Operated in High Temperature Range显示文摘 | Akira Nishimura Kotaro Osada Takuro Tsunoda Masato Yoshimura Masafumi Hirota Eric Hu | 2016 | Journal of Energy and Power Engineering2016，10，8： | 5 |
| 11 | SSJD14101300023292显示文摘 | Shinya Sugimoto Hidetaka Yamada Masazumi Takahashi Yuichi Morohoshi Naotaka Yamaguchi Yuya Tsunoda Hiroyuki Hayashi Haruhiko Sugimura Hirokazu Komatsu | 2014 | Gastric Cancer2014，，4： | 4 |
| 12 | A thickened or indistinct junctional zone on T2-weighted MR images in patients with endometrial carcinoma: pathologic consideration based on microcirculation显示文摘 | Yumiko Oishi Tanaka Masato Nishida Hajime Tsunoda Yoshihito Ichikawa Yukihisa Saida Yuji Itai | 2003 | European Radiology2003，，8： | 2 |
| 13 | Microstructure and Electrochemical Corrosion Behavior of Fe-Cr System Alloys as Substitutes for Ni-Based Brazing Filler Metal显示文摘Two new Fe-Cr system alloys,Fe-20Cr-43Ni-10P(mass%)and Fe-20Cr-20Ni-8P-5Si-2Mo(mass%),have been developed as substitutes for the expensive Ni-based brazing filler metal used in brazing exhaust gas recirculation coolers.The microstructures and melting properties of the alloys were analyzed by electron probe X-ray microanalyzer and differential scanning calorimetry.The electrochemical characteristics of the alloys were investigated by potentiodynamic polarization testing in an electrolyte solution made in accordance with the standards of the Automobile Manufacturers Association of Germany.Furthermore,the corrosion behaviors of the alloys were investigated by constant-potential polarization testing and surface characterization.It is found that both alloys are composed of solid-solution phases and phosphide phases.The solid-solution phases serve as the anode,and the phosphide phases serve as the cathode in the corrosion reaction for both alloys.Fe-20Cr-43Ni-10 P exhibits galvanic corrosion on the entire surface.In contrast,Fe-20Cr-20Ni-8P-5Si-2Mo is attacked at a few localized areas so that the cavities form on the surface.The corrosion potential(E_(corr)) is lower than that of Ni-29Cr-6P-4Si(mass%)for both alloys.This means that the Fe-Cr system alloys are more easily corroded than Ni-29Cr-6P-4Si.The corrosion rate and corrosion resistance cannot be investigated by the corrosion current density(i_(corr)) and polarization resistance(R_p),respectively,because of localized corrosion of the two alloys. | kangdao shi takahiro tsunoda ikuo shohji kotaro matsu yasuhiro taguchi | 2016 | Acta Metallurgica Sinica(English Letters)2016，29，8： | 2 |
| 14 | Phase I/II study of S-1 plus cisplatin combined with peptide vaccinesfor human vascular endothelial growth factor receptor 1 and 2 in patients withadvanced gastric cancer显示文摘 | Toru Masuzawa Yoshiyuki Fujiwara Kaoru Okada Ayumu Nakamura Shuji Takiguchi Kiyokazu Nakajima Hiroshi Miyata Makoto Yamasaki Yukinori Kurokawa Ryuji Osawa Kazuyoshi Takeda Koji Yoshida Takuya Tsunoda Yusuke Nakamura Masaki Mori Yuichiro Doki | 2012 | International Journal of Oncology2012，，4： | 2 |
| 15 | 湖羊、同羊12个同工酶座位的检测显示文摘Gene frequencies of Hu sheep and Tong sheep were obtained with“Random sampling in typical colonies of a central area”. Of the 12 loci tested in Hu sheep, 11 loci were polymorphic. Reliability of the estimated frequencies of 27 alleles reached 0.95 except for PoF, TfA,Tff,Hb-βA and CAF which had reliabilities of 0.5222,0.7478,0.5222,0.6212 and 0.899, respectively. Of the 12 loci tested in Tong sheep, 11 loci were polymorphic. Reliability of the estimated frequency of 25 alleles reached 0.95 except for TfA, TfE and CAF which had reliabilities of 0.931,0.6922 and 0.7924, respectively. The average heterozygosity () and average homozygosity (J) was computed and the J of the two sheep colonies was 0.6619 and 0.6448, respectively. Consistent with our conclusions based on genetic data, previous research divided the native sheep populations of East and South Central Asia into three group: the“Mongolian group”,“South-Asian group” and“European group”. Consequently, the degree of genetic similarity between populations and known groups would seem to provide a reliable means of determining the genetic relationships between populations and may reflect the true genetic origin of Hu sheep and Tong sheep in China [Acta Zoologica Sinica 49(1):134-138,2003]. | 孙伟 常洪 任战军 杨章平 耿荣庆 TSUNODA Kenji | 2003 | 动物学报2003，49，1： | 2 |
| 16 | Hepatectomy simulation discrepancy between radionuclide receptor imaging and CT volumetry: influence of decreased unilateral portal venous flow显示文摘 | Shiro Akaki Yoshihiro Okumura Nobuya Sasai Shuhei Sato Masatoshi Tsunoda Masahiro Kuroda Susumu Kanazawa Yoshio Hiraki | 2003 | Annals of Nuclear Medicine2003，，1： | 2 |
| 17 | The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection显示文摘 | Hideo Ozaki Takehisa Hiraoka Ryuji Mizumoto Seiki Matsuno Yoshiro Matsumoto Toshimichi Nakayama Tsukasa Tsunoda Takashi Suzuki Morito Monden Yoichi Saitoh Hidemi Yamauchi Yoshiro Ogata | 1999 | Surgery Today1999，，1： | 2 |
| 18 | Advantage of Completely Laparoscopic Gastrectomy With Linear Stapled Reconstruction: A Long-term Follow-up Study显示文摘 | Hiroshi Okabe Kazutaka Obama Shigeru Tsunoda Eiji Tanaka Yoshiharu Sakai | 2014 | Annals of Surgery2014，，1： | 2 |
| 19 | 在有在有 diltiazem 的热门治疗以后的长期的肛门裂缝的病人的生活的质量显示文摘 AIM:To assess the physical and mental health of fissure patients before and after topical treatment with diltiazem.METHODS:Consecutive patients were enrolled prospectively into the study.Quality of life was measured with the short-forum 36 health survey(SF-36) before and after 6-wk treatment with diltiazem.Patients scored symptoms of pain,bleeding,and irritation using numeral rating scales at the initial and follow-up visits.Fissure healing was assessed and side effects were noted.RESULTS:Fissures healed in 21 of 30(70%) patients.There were significant reductions in the scores of pain,bleeding,and irritation after 1 wk of treatment,respectively.Four patients experienced perianal itching and one patient reported headache.When measured at baseline,pain and irritation showed a negative impact on two of the eight subscales on the SF-36,respectively(bodily pain and social functioning for pain;vitality and mental health for irritation).Repeating the SF-36 showed an improvement in bodily pain(P = 0.001).Patients whose fissures healed reported an improvement in bodily pain,health-perception,vitality,and mental health(P < 0.05).CONCLUSION:Successful treatment of chronic anal fissure with topical diltiazem leads to improvement in health-related quality of life. | Akira Tsunoda Yasuharu Kashiwagura Ken-ichi Hirose Tadanori Sasaki Nobuyasu Kano | 2012 | World Journal of Gastrointestinal Surgery2012，4，11： | 2 |
| 20 | Morphological traits and biochemical polymorphisms of Myanmar sheep显示文摘 | Tsunoda K Amano K Nozawa K | 2004 | Rep Soc Res Native Livestock2004，21，： | 1 |
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