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| 1 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 2 | HSF1 is essential for the resistance of zebrafish eye and brain tissues to hypoxia/ reperfusion injury 显示文摘 | Tucker NR Middleton RC Le QP | 2011 | PLoS One2011，6，22： | 1 |
| 3 | Greenness in semi-arid areas across the globe 1981–2007 — an Earth Observing Satellite based analysis of trends and drivers显示文摘 | Rasmus Fensholt Tobias Langanke Kjeld Rasmussen Anette Reenberg Stephen D. Prince Compton Tucker Robert J. Scholes Quang Bao Le Alberte Bondeau Ron Eastman Howard Epstein Andrea E. Gaughan Ulf Hellden Cheikh Mbow Lennart Olsson Jose Paruelo Christian Schw | 2012 | Remote Sensing of Environment2012，，： | 1 |
| 4 | Classical heatstroke:clinical andlaboratory assessment显示文摘 | Tucker LE Stanford J Graves B | 1985 | South Med J1985，78，1： | 1 |
| 5 | Arginine:an unusual dietary requirement ofpre-B lymphocytes?显示文摘 | Tucker W Le Bien | 2002 | J Clin Invest2002，110，： | 1 |
| 6 | Laparoscopic nissen fundoplication in a community hospital: patient satisfaction sur- vey显示文摘 | Tucker LE Blatt C Richardson NL | 2005 | South Med J2005，98，： | 1 |
| 7 | Laparoscopic Nissen fundoplication in a community hospital: patient satisfaction survey显示文摘 | Tucker LE Blatt C Richardson NL | 2005 | South Med J2005，98，4： | 1 |
| 8 | A technique to use CT images for in vivo detection and quantification of the spatial dis- tribution of radiation-induced esophagitis显示文摘 | Court LE Tucker SL Gomez D | 2013 | J Appl Clin Med Phys2013，14，3： | 1 |
| 9 | Arginine:an unusual dietary requirement ofpre-B lymphocytes显示文摘 | Tucker W Le Bien | 2002 | Clin Invest2002，110，10： | 1 |
| 10 | HSF1 is essen-tial for the resistance of zebrafish eye and brain tissues to hypoxia/reperfusion injury 显示文摘 | Tucker NR Middleton RC Le QP | 2011 | PLoS One2011，6，22： | 1 |
| 11 | Arginine:an unusual dietary requirement ofpre-B lymphocytes显示文摘 | Tucker W Le Bien | 2002 | J Clin Invest2002，110，14： | 1 |
| 12 | Timolol metabolism and debrisoquine oxidation polymorphism:a population study 显示文摘 | Lennard MS Lewis RV Brawn LA Tucker GT Ramsay LE Jackson PR | 1989 | Br J Clin Pharmacol1989，27，42： | 1 |
| 13 | Clinical pharmacokinetics of local anaesthetics显示文摘 | Tucker GT Mather LE | 1979 | Clin pharmacokinet1979，4，4： | 1 |
| 14 | Laparoscopic Nissen fundoplication in a community hospital: patient satisfaction survey 显示文摘 | Tucker LE Blatt C Richardson NL | 2005 | South Med J2005，98，4： | 1 |
| 15 | Argonaute(AGO)proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells(MSCs)显示文摘As multipotent progenitor cells,mesenchymal stem cells(MSCs)can renew themselves and give rise to multiple lineages including osteoblastic,chondrogenic and adipogenic lineages.It’s previously shown that BMP9 is the most potent BMP and induces osteogenic and adipogenic differentiation of MSCs.However,the molecular mechanism through which BMP9 regulates MSC differentiation remains poorly understood.Emerging evidence indicates that noncoding RNAs,especially microRNAs,may play important roles in regulating MSC differentiation and bone formation.As highly conserved RNA binding proteins,Argonaute(AGO)proteins are essential components of the multi-protein RNA-induced silencing complexes(RISCs),which are critical for small RNA biogenesis.Here,we investigate possible roles of AGO proteins in BMP9-induced lineage-specific differentiation of MSCs.We first found that BMP9 upregulated the expression of Ago1,Ago2 and Ago3 in MSCs.By engineering multiplex siRNA vectors that express multiple siRNAs targeting individual Ago genes or all four Ago genes,we found that silencing individual Ago expression led to a decrease in BMP9-induced early osteogenic marker alkaline phosphatase(ALP)activity in MSCs.Furthermore,we demonstrated that simultaneously silencing all four Ago genes significantly diminished BMP9-induced osteogenic and adipogenic differentiation of MSCs and matrix mineralization,and ectopic bone formation.Collectively,our findings strongly indicate that AGO proteins and associated small RNA biogenesis pathway play an essential role in mediating BMP9-induced osteogenic differentiation of MSCs. | Yukun Mao Na Ni Linjuan Huang Jiaming Fan Hao Wang Fang He Qing Liu Deyao Shi Kai Fu Mikhail Pakvasa William Wagstaff Andrew Blake Tucker Connie Chen Russell R.Reid Rex C.Haydon Sherwin H.Ho Michael J.Lee Tong-Chuan He Jian Yang Le Shen Lin Cai Hue H.Luu | 2021 | Genes & Diseases2021，8，6： | 1 |
| 16 | Control of maching induced edge chipping on glass ceramics 显示文摘 | S Ng D Le S Tucker | 1996 | Proceeding of the 1996 ASME International Mechanical Engineering Congress and Exposition Manufacturing Engineering Division Atlanta1996，1996，11： | 1 |
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