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| 1 | 创口愈合的生理学显示文摘伤口愈合的形式可分为Ⅰ期、Ⅱ期和Ⅲ期愈合。本文介绍各期愈合的生理作用,它们有共同之处:即由多种细胞、酶和生物因子参与下完成。不同之处是按伤口情况而定。我们了解这种过程而采取适当措施可以促进伤口愈合。 | Tudor R 罗燕萍 | 1992 | 国外医学(护理学分册)1992，11，6： | 28 |
| 2 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 3 | 教师在学生中心教学中的作用显示文摘人们普遍认为学生中心型教学法改变了学生的作用,但很少有人指出学生中心教学也需要相应改变教师的作用。本文讨论了教师在学生中心教学中所起的学习顾问的作用及相应的责任。 | Ian Tudor 王全良 王英杰 | 1994 | 外语教学理论与实践1994，，3： | 7 |
| 4 | COX-2 as a potential biomarker and therapeutic target in melanoma显示文摘With a constantly increasing incidence,cutaneous melanoma has raised the need for a better understanding of its complex microenvironment that may further guide therapeutic options.Melanoma is a model tumor in immuno-oncology.Inflammation represents an important hallmark of cancer capable of inducing and sustaining tumor development.The inflammatory process also orchestrates the adaptative immunosuppression of tumor cells that helps them to evade immune destruction.Besides its role in proliferation,angiogenesis,and apoptosis,cyclooxygenase-2(COX-2)is a well-known promoter of immune suppression in melanoma.COX-2 inhibitors are closely involved in this condition.This review attempts to answer two controversial questions:is COX-2 a valuable prognostic factor?Among all COX-2 inhibitors,is celecoxib a suitable adjuvant in melanoma therapy? | Diana Valentina Tudor Ioana Baldea Mihai Lupu Teodor Kacso Eniko Kutasi Andreea Hopartean Roland Stretea Adriana Gabriela Filip | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 5 | 加拿大的欠平衡钻井显示文摘 | Tudor,R 邢雷 | 1998 | 国外钻井技术1998，13，5： | 5 |
| 6 | 非线性器件的建模与测试显示文摘1引言
在快速发展、竞争激烈的非线性设计领域,能够用最短的时间将新器件技术转变为最终产品的能力是公司取得成功的关键。近来发展最好的方法是使用行为模型。此方法与相关测试测量方案的优点相结合,可以极大地缩短产品设计周期。 | Tudor Williams Randeep Saini Simon Mathias Andreas Henkel | 2015 | 国外电子测量技术2015，34，8： | 4 |
| 7 | Viscoelastic tests in liver disease: where do we stand now?显示文摘Hemostasis is a complex physiological process based on the balance between procoagulant and anticoagulant systems to avoid pathological bleeding or thrombosis.The changes in standard coagulation tests in liver disease were assumed to reflect an acquired bleeding disorder,and cirrhotic patients were considered naturally anticoagulated.In the light of the new evidence,the theory of rebalanced hemostasis replaced the old concept.According to this model,the hemostatic alteration leads to a unique balance between pro-coagulant,anticoagulant,and fibrinolytic systems.But the balance is fragile and may prone to bleeding or thrombosis depending on various risk factors.The standard coagulation tests[INR(international normalized ratio),platelet count and fibrinogen]only explore parts of the hemostasis,not offering an entire image of the process.Rotational thromboelastometry(ROTEM)and thromboelastography(TEG)are both point of care viscoelastic tests(VET)that provide real-time and dynamic information about the entire hemostasis process,including clot initiation(thrombin generation),clot kinetics,clot strength,and clot stability(lysis).Despite prolonged PT/INR(international normalized ratio of prothrombin time)and low platelet counts,VET is within the normal range in many patients with both acute and chronic liver disease.However,bleeding remains the dominant clinical issue in patients with liver diseases,especially when invasive interventions are required.VET has been shown to asses more appropriately the risk of bleeding than conventional laboratory tests,leading to decrial use of blood products transfusion.Inappropriate clotting is common but often subtle and may be challenging to predict even with the help of VET.Although VET has shown its benefit,more studies are needed to establish cut-off values for TEG and ROTEM in these populations and standardization of transfusion guidelines before invasive interventions in cirrhotic patients/orthotopic liver transplantation. | Alina Buliarca Adelina Horhat Tudor Mocan Rares Craciun Bogdan Procopet Zeno Sparchez | 2021 | World Journal of Gastroenterology2021，27，23： | 3 |
| 8 | Effects of Pantoprazole in experimental acute pancreatitis显示文摘 | Thilo Hackert Stefan Tudor Klaus Felix Dmitry Dovshanskiy Werner Hartwig Wolfgang A. Simon Jens Werner | 2010 | Life Sciences2010，，17： | 3 |
| 9 | Endoscopic or percutaneous biliary drainage in hilar cholangiocarcinoma:When and how?显示文摘Hilar cholangiocarcinoma (hCCA) is a primary liver tumor associated with a dimprognosis. The role of preoperative and palliative biliary drainage has long beendebated. The most common techniques are endoscopic retrograde cholangiopancreatography(ERCP) and percutaneous transhepatic biliary drainage (PTBD);however, recently developed endoscopic ultrasound-assisted methods are gainingmore atention. Selecting the best available method in any specific scenario iscrucial, yet sometimes challenging. Thus, this review aimed to discuss theavailable techniques, indications, perks, pitfalls, and timing-related issues in themanagement of hCCA. In a preoperative setting, PTBD appears to have someadvantages: low risk of postprocedural complications (namely cholangitis) andbetter priming for surgery. For palliative purposes, we propose ERCP/PTBDdepending on the experience of the operators, but also on other factors: the levelof bilirubin (if very high, rather PTBD), length of the stenosis and the presence ofcholangitis (PTBD), ERCP failure, or altered biliary anatomy. | Tudor Mocan Adelina Horhat Emil Mois Florin Graur Cristian Tefas Rares Craciun Iuliana Nenu Mihaela Spârchez Zeno Sparchez | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 3 |
| 10 | Post-operative computed tomography scan – reliable tool for quality assessment of complete mesocolic excision显示文摘BACKGROUND Quality control in colon cancer surgery is an ongoing debate ever since standardization proved to be highly efficient in improving survival in rectal cancer. Complete mesocolic excision(CME) is widely acclaimed as the new goldstandard in colon cancer resections, thus it is imperative to establish quality criteria of CME in order to make it easily understood and verified by surgeons worldwide. One simple and reproducible tool could be the measurement of arterial stumps postoperatively and a straightforward way to test its reliability is to test it in a comparative study between CME and non-CME surgery.AIM To validate arterial stump measurement as a surgical quality tool by comparing CME with conventional radical colectomies.METHODS This was a retrospective study, carried out on a prospective database. We collected data from two groups of patients, divided according to standard CME with D2 central vascular ligation(group A) and non-standardized surgery(group B). The two groups were compared with regard to the arterial stump length after right-and left-sided colectomies for colon cancer. The actual stump lengths of the ileocolic artery(ICA) and inferior mesenteric artery(IMA) were compared with their theoretical best D2 position of predicted ligation levels(D2 PLLs) for calculating the potential for improvement. Measurements on follow-up computed tomography scans were carried out by three observers. Pathological data were recorded(specimen length, lymph node yield) and correlated with stump length.RESULTS We analysed 58 colectomies. The stump lengths(mean ± SD) in group A were16.97 ± 4.77 mm for ICA and 31.70 ± 15.71 mm for IMA, whereas group B had 49.93 ± 20.29 mm for ICA and 67.24 ± 28.71 mm for IMA. Shorter lengths were obtained in group A, by a mean difference of 35.66 mm(χ~2 = 27.38, P < 0.001),which was significant for all types of colectomies. Except for a 5.85 ± 4.71 mm difference for right colectomies, all the ligations from group A significantly reached their potential height(0.26 ± 12.18 mm from D2 PLL; χ~2 = 0.005, P = 0.944).Apart from three left colectomies, group B failed to reach D2 PLL, by a mean difference of 32.14 ± 26.15 mm(χ~2 = 21.77, P < 0.001). The calculated improvement potentials were significantly shorter in group A than in group B, by a mean of 31.88 mm(χ~2= 22.13, P < 0.001). The large spread of results in group B showed that there is significant variability(P = 0.004) when compared to standard surgery. Significant correlations were found between stump length, specimen length and number of lymph nodes(P = 0.018 and P = 0.008 respectively). No statistical difference was found between observers' measurements(P = 0.866).CONCLUSION Arterial stump monitoring is a significant step in defining surgical quality, as longer stumps contain residual mesocolic tissue and correlate with major prognostic factors. | Cristian Livadaru Stefan Morarasu Tudor Cristian Frunza Florina A Ghitun Elena Florina Paiu-Spiridon Florina Sava Cristina Terinte Dan Ferariu Sorinel Lunca Gabriel Mihail Dimofte | 2019 | World Journal of Gastrointestinal Oncology2019，11，3： | 2 |
| 11 | Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma显示文摘BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in HCC.AIM To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to RO7070179.METHODS In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of RO7070179.RESULTS Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased toxicity.This study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes in either m RNA level or DCE-MRI within 1 cycle of therapy. | Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee | 2019 | World Journal of Clinical Oncology2019，10，3： | 2 |
| 12 | A phase II open-label randomized study to assess the efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy显示文摘 | Gy?rgy Bodoky Constanta Timcheva David Spigel Phillip Stella Tudor Ciuleanu G. Pover N. Tebbutt | 2012 | Investigational New Drugs2012，，3： | 2 |
| 13 | WONCA研究论文摘要汇编——社区医疗中用药错误存在问题及解决办法的重要性分级:一项基于重要性排列法促进用药安全的研究显示文摘背景用药错误的研究主要集中在医院内。本文旨在研究社区医疗中的用药错误,调查引起用药错误的主要原因并提出相关的解决办法。方法 2013年9月—2014年11月,使用重要性排列法对用药错误存在问题及解决办法进行确定和分级。500位来自伦敦西北部的社区医师参加了开放式问卷调查,回收有效问卷113份,存在问题有48个,相关解决办法有45种。从500位社区医师中随机抽选57位,对存在问题及解决办法进行评分,并根据评分情况,列出用药错误存在问题及解决办法的重要性级别表。结果前3个存在问题是:给患者开药的不同的医生在用药方面的看法不完全一致性,不适当的用药指导以及质量较差的出院总结。前3个解决办法是:设计标准的出院总结模板,减少不必要的处方以及最大限度的减少多药疗法。结论社区医师在用药管理、用药流程质量控制及用药指导方面给出了一系列建议。认为,这些可行的负担得起的干预方式在很大程度上可以预防用药错误的发生。 | TUDOR CAR L PAPACHRISTOU N GALLAGHER J 本刊编辑部 | 2017 | 中国全科医学2017，20，2： | 2 |
| 14 | 护士在以患者为中心的结核病照护中的角色显示文摘护士是全球医疗保健服务的重要提供者,同样,也是结核病患者的主要照护者。尽管结核病病死率在过去24年有所下降,但是每年仍有超过150万患者死于结核。结核病是全球传染性疾病导致的第二位死因,在某些地区甚至成为首位死因。世界卫生组织(WHO)刚刚发布了新的20年抗击结核战略规划,即'终止结核策略(2016-2035)',该策略包含三个主要支柱,即以患者为中心的照护和预防;强有力的政策和支持系统;加强研究与创新。根据WHO'终止结核策略',护士在未来20年的结核控制中将发挥重要的作用。通过提供并倡导以患者为中心的护理能够对全球结核控制产生很大影响。 | Carrie Tudor 郭爱敏 | 2016 | 中国护理管理2016，16，3： | 2 |
| 15 | Testosterone,cardiomyopathies,and heart failure:a narrative review显示文摘Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways. It produces several changes in cardiomyocytes, the main actor of cardiomyopathies, which are characterized by pathological remodeling, eventually leading to heart failure. Testosterone is involved in contractility, in the energy metabolism of myocardial cells, apoptosis, and the remodeling process. In myocarditis, testosterone directly promotes the type of inflammation that leads to fibrosis, and influences viremia with virus localization. At the same time, testosterone exerts cardioprotective effects that have been observed in different studies. There is increasing evidence that low endogenous levels of testosterone have a negative impact in some cardiomyopathies and a protective impact in others. This review focuses on the interrelationships between testosterone and cardiomyopathies and heart failure. | Rodica Diaconu Ionuţ Donoiu Oana Mirea Tudor Adrian Bălşeanu | 2021 | Asian Journal of Andrology2021，23，4： | 2 |
| 16 | Robot-assisted surgery for gastric cancer显示文摘Minimally invasive surgery for gastric cancer is a rela-tively new research field, with convincing results mostly stemming from Asian countries. The use of the robotic surgery platform, thus far assessed as a safe procedure, which is also easier to learn, sets the background for a wider spread of minimally invasive technique in the treatment of gastric cancer. This review will cover the literature published so far, analyzing the pros and cons of robotic surgery and highlighting the remaining study questions. | livia procopiuc stefan tudor mircea manuc mircea diculescu catalin vasilescu | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 2 |
| 17 | The BCL-2 Family Reunion显示文摘 | Jerry E. Chipuk Tudor Moldoveanu Fabien Llambi Melissa J. Parsons Douglas R. Green | 2010 | Molecular Cell2010，，3： | 2 |
| 18 | Successful management of post-tumor resection middle cerebral artery thrombosis with stent-assisted angioplasty and thrombolytic therapy:case report显示文摘 | ELAD L MICHAEL H TUDOR J | 2004 | Neurosurgery2004，55，3： | 1 |
| 19 | Identification of a putative intestinal stem cell and early lineage marker: musashi-1显示文摘 | Potten CS Booth C Tudor GL | 2005 | Differentiation2005，71，1： | 1 |
| 20 | Amicro electromagnetic generator for vibration energy harvesting 显示文摘 | Beeby S P Torah R N Tudor M J | 2007 | Journal of Micromechanics and Microengineering2007，17，7： | 1 |
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