2篇
您的检索式：作者名="Turab Syed"
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| 1 | Current Progress of Phytomedicine in Glioblastoma Therapy显示文摘Glioblastoma multiforme,an intrusive brain cancer,has the lowest survival rate of all brain cancers.The chemotherapy utilized to prevent their proliferation and propagation is limited due to modulation of complex cancer signalling pathways.These complex pathways provide infiltrative and drug evading properties leading to the development of chemotherapy resistance.Therefore,the development and discovery of such interventions or therapies that can bypass all these resistive barriers to ameliorate glioma prognosis and survival is of profound importance.Medicinal plants are comprised of an exorbitant range of phytochemicals that have the broad-spectrum capability to target intrusive brain cancers,modulate anti-cancer pathways and immunological responses to facilitate their eradication,and induce apoptosis.These phytocompounds also interfere with several oncogenic proteins that promote cancer invasiveness and metastasis,chemotherapy resistance and angiogenesis.These plants are extremely vital for promising anti-glioma therapy to avert glioma proliferation and recurrence.In this review,we acquired recent literature on medicinal plants whose extracts/bioactive ingredients are newly exploited in glioma therapeutics,and also highlighted their mode of action and pharmacological profile. | Fahad Hassan Shah Saad Salman Jawaria Idrees Fariha Idrees Syed Turab Ali Shah Abid Ali Khan Bashir Ahmad | 2020 | Current Medical Science2020，40，6： | 0 |
| 2 | Intraosseous device for arthrodesis in foot and ankle surgery: Review of the literature and biomechanical properties显示文摘BACKGROUND Arthrodesis is the surgical fusion of a diseased joint for the purposes of obtaining pain relief and stability.There have been numerous fixation devices described in literature for foot and ankle arthrodesis,each with their own benefits and drawbacks.AIM To review the use of intraosseous devices in foot and ankle surgery.METHODS There were 9 papers included in the review(6 clinical and 3 experimental studies)all evaluating arthrodesis in the foot and ankle using the IOFIX device(Extremity Medical™,Parsippany,NJ,United States).Outcome scores,union rates,as well as complications were analysed.RESULTS IOFIX appears to be safe and effective in achieving arthrodesis of the 1st metatarsophalangeal,and talonavicular joints with early rehabilitation.In comparison to plate/screw constructs there were fewer soft tissue complications and issues of metalwork prominence.Cadaveric and biomechanical studies on the use of intramedullary fixation for fusion of the tarsometatarsal and ankle joint showed decreased load to failure,cycles to failure and stiffness in comparison to traditional fusion methods using plates and screws,however IOFIX devices produced higher compressive forces at the joint.CONCLUSION We describe the reasons for which this biomechanical behavior of the intraosseous fixation may be favorable,until prospective and comparative studies with largersample size and longer follow-up confirm the effectiveness and limitations of the method. | Biju Benjamin Paul Ryan Yulia Chechelnitskaya Levent Bayam Turab Syed Efstathios Drampalos | 2021 | World Journal of Orthopedics2021，12，12： | 0 |
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