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| 1 | Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model显示文摘Objective: To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis(CBP) rat model.Methods: The SpragueDawley rats were divided into 4 groups,including control,ciprofloxacin,anthocyanins and anthocyanins with ciprofloxacin groups(n=8 in each group).Then,drip infusion of bacterial suspension(Escherichia coli Z17O_2:K_1:H^-) into Sprague-Dawley rats was conducted to induce CBP.In 4 weeks,results of prostate tissue,urine culture,and histological analysis on the prostate were analyzed for each group.Results: The use of ciprofloxacin,anthocyanins,and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group(P<0.05).The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group(P<0.05).Conclusions: These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects,as well as a synergistic effect with ciprofloxacin.Therefore,we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success. | Byung Il Yoon Woong Jin Bae Yong Sun Choi Su Jin Kim U Syn Ha Sung-Hoo Hong Dong Wan Sohn Sae Woong Kim | 2018 | Chinese Journal of Integrative Medicine2018，24，8： | 11 |
| 2 | Increased circulating level of interleukin-6 and CD8+T cell exhaustion are associated with progression of COVID-19显示文摘Background: Coronavirus disease 2019(COVID-19)is pandemic.It is critical to identify COVID-19 patients who are most likely to develop a severe disease.This study was designed to determine the clinical and epidemiological features of COVID-19 patients associated with the development of pneumonia and factors associated with disease progression.Methods:: Seventy consecutive patients with etiologically confirmed COVID-19 admitted to PLA General Hospital in Beijing,China from December 27,2019 to March 12,2020 were enrolled in this study and followed-up to March 16,2020.Differences in clinical and laboratory findings between COVID-19 patients with pneumonia and those without were determined by theχ2 test or the Fisher exact test(categorical variables)and independent group t test or Mann–Whitney U test(continuous variables).The Cox proportional hazard model and Generalized Estimating Equations were applied to evaluate factors that predicted the progression of COVID-19.Results: The mean incubation was 8.67(95%confidence interval,6.78–10.56)days.Mean duration from the first test severe acute respiratory syndrome coronavirus 2-positive to conversion was 11.38(9.86–12.90)days.Compared to pneumonia-free patients,pneumonia patients were 16.5 years older and had higher frequencies of having hypertension,fever,and cough and higher circulating levels of neutrophil proportion,interleukin-6,low count(<190/µl)of CD8+T cells,and neutrophil/lymphocyte ratio.Thirteen patients deteriorated during hospitalization.Cox regression analysis indicated that older age and higher serum levels of interleukin-6,C-reactive protein,procalcitonin,and lactate at admission significantly predicted the progression of COVID-19.During hospitalization,circulating counts of T lymphocytes,CD4+T cells,and CD8+T cells were lower,whereas neutrophil proportion,neutrophil/lymphocyte ratio,and the circulating levels of interleukin-6,C-reactive protein,and procalcitonin were higher,in pneumonia patients than in pneumonia-free patients.CD8+lymphocyte count in pneumonia patients did not recover when discharged.Conclusions: Older age and higher levels of C-reactive protein,procalcitionin,interleukin-6,and lactate might predict COVID-19 progression.T lymphocyte,especially CD8+cell-mediated immunity is critical in recovery of COVID-19.This study may help in predicting disease progression and designing immunotherapy for COVID-19. | Peng-Hui Yang Yi-Bo Ding Zhe Xu Rui Pu Ping U Jin Yan Ji-Luo Liu Fan-Ping Meng Lei Huang Lei Shi Tian-Jun Jiang En-Qiang Qin Min Zhao Da-Wei Zhang Peng Zhao Ling-Xiang Yu Zhao-Hai Wang Zhi-Xian Hong Zhao-Hui Xiao Qing Xi De-Xi Zhao Peng Yu Cai-Zhong Zhu Zhu Chen Shao-Geng Zhang Jun-Sheng Ji Fu-Sheng Wang Guang-Wen Cao | 2020 | Infectious Diseases of Poverty2020，9，6： | 3 |
| 3 | IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality显示文摘 | Zhang Hong Neuh?fer Patrick Song Liang Rabe Bj?rn Lesina Marina Kurkowski Magdalena U Treiber Matthias Wartmann Thomas Regnér Sara Thorlacius Henrik Saur Dieter Weirich Gregor Yoshimura Akihiko Halangk Walter Mizgerd Joseph P Schmid Roland | 2013 | Journal of Clinical Investigation2013，，3： | 2 |
| 4 | Wear mechanism of multiphase friction materials with different phenolic resin matri- ces显示文摘 | HONG U S JUNG S L CHO K H | 2009 | Wear2009，266，78： | 1 |
| 5 | The use of bacterial spore formers as probiotics 显示文摘 | HUYNH A HONG D U C SIMONM M | 2005 | Annual Review of Microbiology2005，29，4： | 1 |
| 6 | Electrochemical kinetics of the high entropy alloys in aqueous environ- ments a comparison with type 304 stainless steel 显示文摘 | Chen Y Y Hong U T Shih H C | 2005 | Corrosion Science2005，47，11： | 1 |
| 7 | Effects of minimally invasive procedures for removal of intracranial hematoma on matrix metalloproteinase expression and blood-brain barrier permeability in perihematomal brain tissues显示文摘 | W u G Wang L Hong Z | 2011 | Neurol Res2011，33，3： | 1 |
| 8 | Nitric oxide function and signaling in plant disease resistance 显示文摘 | Hong J K Yun B W Kang J G Raja M U Kwon E Sorhagen K Chu C C Wang Y Q Loake G J | 2008 | Journal of Experimental Botany2008，59，2： | 1 |
| 9 | Distribution and characteristics of PAHs in sediments from the marine environment of Korea显示文摘 | YIM U H HONG S H SHIM W J | 2007 | Chemosphere2007，68，1： | 1 |
| 10 | 显示文摘 | Liu Wenjian Sun Baozhong H u Hong | 2007 | Polymer Composites2007，28，2： | 1 |
| 11 | Kinetic behavior of LiFe- MgPO4 cathode material for Li-ion batteries显示文摘 | Hong J Wang C S Kasavajjula U | 2006 | J Power Sources2006，162，2： | 1 |
| 12 | Inhibition of Proliferation of Prostate Cancer Cell Line DU-145 in vitro and in vivo Using Salvia miltiorrhiza Bunge显示文摘Objective:To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge.(SM)on the castration-resistant prostate cancer(CRPC)cell line DU-145 in vitro and in vivo.Methods:Prostate cancer cell line(DU-145)and normal prostate cell line(RWPE-1)were treated with SM at different concentrations(3.125,12.5,25 and 50μg/mL)to investigate the antiproliferative effects.DNA laddering analysis was performed to investigate the apoptosis of DU-145 cells.Molecular mechanism was investigated by Western blot analysis of p53,Bcl-2,prostate specific antigen(PSA),and androgen receptor(AR).Six-week-old male BALB/c nude mice were randomly divided into normal control group(n=101)and treated group(n=101)which administered 500 mg/kg SM for 2 weeks.Tumor volumes were measured.Results:Treatment with SM resulted in a dose-dependent decrease in cell number of DU-145 cells in comparison with RWPE-1.DNA laddering analysis indicated the apoptosis of DU-145 cells.Treatment with SM increased the expression of p53 and reduced the expression of Bcl-2 proteins.The levels of PSA were considerably reduced in SM-treated group compared to the controls,and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in PSA.In the tumour xenograft study,SM given once a day for 2 weeks significantly inhibited tumour growth.Conclusion:SM might contribute to the anticancer actions such as induction of apoptosis and inhibition of proliferation of prostate cancer cells. | Woong Jin Bae Jin Bong Choi Kang Sup Kim U Syn Ha Sung Hoo Hong Ji Youl Lee Tae-Kon Hwang Sung Yeoun Hwang WANG Zhi-ping Sae Woong Kim | 2020 | Chinese Journal of Integrative Medicine2020，26，7： | 1 |
| 13 | Physical and chemical properties of a new root-end filling materials 显示文摘 | TORABINEJAD M HONG C U MCDONALD F | 1995 | J Endod1995，21，7： | 1 |
| 14 | Bingding and Mobilisation of Heavy Metals in Contaminated SedimentsAffected by pH and Redox Potential 显示文摘 | Calmano W Hong J Forstner U | 1993 | Water Science & Technology1993，28，89： | 1 |
| 15 | Correlation of the M23C6 precipitation morphologh with grain boundary characteristics in austenitic stainless steels 显示文摘 | Hong H U Rho B S Nam S W | 2002 | Mater Sci And Eng:A2002，318，2： | 1 |
| 16 | measurement and analysis of propylene solubility in polymer electrolytes containing silver salts显示文摘 | S U Hong C K Kim Y S Kang | 2000 | Macromolecules2000，33，21： | 1 |
| 17 | Performance of a I kW-class PEMFC stack using TiN-coated 316 stainless steel bipolar plates显示文摘 | CHO E A JEON U S HONG S A | 2005 | Journal of Power Sources2005，142，： | 1 |
| 18 | Separation of amino acid mix- tures using muhilayer polyelectrolyte nanofiltration membranes 显示文摘 | HONG S U BRUENING M L | 2006 | Journal of Membrane Science2006，280，12： | 1 |
| 19 | Low-carbon benefit analysis on IX} penetration distribution system显示文摘 | Shaoyun G E Li X U Hong L I U | | Journal of Modern Power Systems and Clean Energy0，3，13： | 1 |
| 20 | 显示文摘 | Bang C U Hong Y C Dong Hun Shin | 2005 | Chem Phys Letters2005，413，： | 1 |
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