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| 1 | Advances in endoscopic retrograde cholangiopancreatography for the treatment of cholangiocarcinoma显示文摘Cholangiocarcinoma(CCA) is a malignancy of the bileducts that carries high morbidity and mortality. Patients with CCA typically present with obstructive jaundice, and associated complications of CCA include cholangitis and biliary sepsis. Endoscopic retrograde cholangiopancreatography(ERCP) is a valuable treatment modality for patients with CCA, as it enables internal drainage of blocked bile ducts and hepatic segments by using plastic or metal stents. While there remains debate as to if bilateral(or multi-segmental) hepatic drainage is required and/or superior to unilateral drainage, the underlying tenant of draining any persistently opacified bile ducts is paramount to good ERCP practice and good clinical outcomes. Endoscopic therapy for malignant biliary strictures from CCA has advanced to include ablative therapies via ERCP-directed photodynamic therapy(PDT) or radiofrequency ablation(RFA). While ERCP techniques cannot cure CCA, advancements in the field of ERCP have enabled us to improve upon the quality of life of patients with inoperable and incurable disease. ERCP-directed PDT has been used in lieu of brachytherapy to provide neoadjuvant local tumor control in patients with CCA who are awaiting liver transplantation. Lastly, mounting evidence suggests that palliative ERCP-directed PDT, and probably ERCPdirected RFA as well, offer a survival advantage to patients with this difficult-to-treat malignancy. | Dushant S Uppal Andrew Y Wang | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 18 |
| 2 | Update on the endoscopic treatments for achalasia显示文摘Achalasia is the most common primary motility disorder of the esophagus and presents as dysphagia to solids and liquids. It is characterized by impaired deglutitive relaxation of the lower esophageal sphincter. Highresolution manometry allows for definitive diagnosis and classification of achalasia, with type Ⅱ being the most responsive to therapy. Since no cure for achalasia exists, early diagnosis and treatment of the disease is critical to prevent end-stage disease. The central tenant of diagnosis is to first rule out mechanical obstruction due to stricture or malignancy, which is often accomplished by endoscopic and fluoroscopic examination. Therapeutic options include pneumatic dilation(PD), surgical myotomy, and endoscopic injection of botulinum toxin injection. Heller myotomy and PD are more efficacious than pharmacologic therapies and should be considered first-line treatment options. Per oral endoscopic myotomy(POEM) is a minimally-invasive endoscopic therapy that might be as effective as surgical myotomy when performed by a trained and experienced endoscopist, although long-term data are lacking. Overall, therapy should be individualized to each patient's clinical situation and based upon his or her risk tolerance, operative candidacy, and life expectancy. In instances of therapeutic failure or symptom recurrence re-treatment is possible and can include PD or POEM of the wall opposite the site of prior myotomy. Patients undergoing therapy for achalasia require counseling, as the goal of therapy is to improve swallowing and prevent late manifestations of the disease rather than to restore normal swallowing, which is unfortunately impossible. | Dushant S Uppal Andrew Y Wang | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 3 | Comparative evaluation of surface swab and quantitative ful thickness wound biopsy culture in burn patients显示文摘 | Uppal SK Ram S Kwatra B | | 0，，04： | 1 |
| 4 | Changes in sugar content and invertase activity in tubders of some Indian potato varieties stored at low temperature显示文摘 | Uppal D S | 1990 | Photo Research1990，33，： | 1 |
| 5 | Angiotensin converting enzyme inhibitors and cough--a north Indian study 显示文摘 | Uppal M Anuradha S | 1998 | J Assoc Physicians Indian1998，46，5： | 1 |
| 6 | Total phenolic content and antioxidant capacity of extracts obtained from six important fruit residues 显示文摘 | Babbar N Oberoi H S Uppal D S | 2011 | Food Res Int2011，44，： | 1 |
| 7 | Changes of reducing sugar and invertase activity in cold-stored potato tubers显示文摘 | Uppal D S Verma S C | 1990 | Potato Research1990，33，： | 1 |
| 8 | Mutations in 15- hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy显示文摘 | Uppal S Diggle CP Cart IM | 2008 | Nat Genet2008，40，6： | 1 |
| 9 | Robust FDI applied to thruster faults of a satellite system 显示文摘 | PATTON R J UPPAL F J SIMANI S | 2010 | Control Engineering Practice2010，9，18： | 1 |
| 10 | Mutations in 15-hydroxypros?taglandin dehy drogenase cause primary hypertrophic usteoarthropathy Erratum in显示文摘 | Uppal S Diggle CP Carr 1M el al | 2008 | Nal Genel2008，40，7： | 1 |
| 11 | Use of encapsulated calcium carbide to reduce denitrifieation losses from urea-fertilized flooded rice显示文摘 | BANERJEE N K MOSIER A R UPPAL K S | 1990 | Mitteilungen der deutschen Boden Knundliehen Gesellshaft1990，60，： | 1 |
| 12 | The effect of short fatty acids on calcium flux rates across isolated rumen epithelium of hay-fed and con-centrate-fed sheep显示文摘 | Uppal S K Wolf K Materns H | 2003 | Journal of Animal Physiology and Animal Nutrition2003，87，12： | 1 |
| 13 | Effect of body mass index on angle of needle insertion during ultrasound-guided lateral sagittal infraclavicular brachial plexus block 显示文摘 | Kalagara HK Uppal V McKinlay S | 2015 | J Clin Anesth2015，27，5： | 1 |
| 14 | Changes of reducing sugar and invertase ac- tivity in coldstored potato tubers显示文摘 | Uppal D S Verma S C | 1990 | Potato Research1990，33，： | 1 |
| 15 | Adult onset Still's disease in northern India:comparison with juvenile onset Still's disease显示文摘 | PANDE I R KUMAR A | 1995 | Br J Rheumatol1995，34，5： | 1 |
| 16 | Post harvest quality deterioration in sugarcane under different environmental conditions 显示文摘 | Bhatia S Jyoti Uppal S K Thind K S Batta S K | 2009 | Sugar Tech2009，11，2： | 1 |
| 17 | The effects of a single dose of 5-fluorouraeil on keloid scars: a clinical trial of timed wound irrigation after extralesional excision显示文摘 | Uppal RS Khan U Kakar S | 2001 | Plast Reconstr Surg2001，108，5： | 1 |
| 18 | Novasure as a mechanical endometrial preparation agent in large uteri显示文摘 | Potti S Uppal S Chatwani A J | 2012 | J Soci Laparoendosc Surg2012，16，4： | 1 |
| 19 | Data mining emo- gender differences in MySpaee 显示文摘 | THELWALL M WILKINSON D UPPAL S | 2010 | Journal of the American Society for Information Science and Technology2010，61，1： | 1 |
| 20 | A cost-effectiveness analysis of conventional and nurse-led telephone follow-up after nasal septal surgery显示文摘 | Uppal S Nadig S Smith L | 2004 | Ann R Coll Surg Engl2004，86，4： | 1 |
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