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| 1 | Chemotherapy and molecular targeting therapy for recurrent cervical cancer显示文摘For patients with primary stage IVB, persistent, or recurrent cervical cancer, chemotherapy remains the standard treatment, although it is neither curative nor associated with long-term disease control. In this review, we summarized the history of treatment of recurrent cervical cancer, and the current recommendation for chemotherapy and molecular targeted therapy. Eligible articles were identified by a search of the MEDLINE bibliographical database for the period up to November 30, 2014. The search strategy included the following any or all of the keywords: 'uterine cervical cancer', 'chemotherapy', and 'targeted therapies'. Since cisplatin every 21 days was considered as the historical standard treatment for recurrent cervical cancer, subsequent trials have evaluated and demonstrated activity for other agents including paclitaxel, gemcitabine, topotecan and vinorelbine among others. Accordingly, promising agents were incorporated into phase III trials. To examine the best agent to combine with cisplatin, several landmark phase III clinical trials were conducted by Gynecologic Oncology Group(GOG) and Japan Clinical Oncology Group(JCOG). Through, GOG204 and JCOG0505, paclitaxel/cisplatin(TP) and paclitaxel/carboplatin(TC) are now considered to be the recommended therapies for recurrent cervical cancer patients. However, the prognosis of patients who are already resistant to chemotherapy, are very poor. Therefore new therapeutic strategies are urgently required. Molecular targeted therapy will be the most hopeful candidate of these strategies. From the results of GOG240, bevacizumab combined with TP reached its primary endpoint of improving overall survival(OS). Although, the prognosis for recurrent cervical cancer patients is still poor, the results of GOG240 shed light on the usefulness of molecular target agents to chemotherapy in cancer patients. Recurrent cervical cancer is generally considered incurable and current chemotherapy regiments offer only modest gains in OS, particularly for patients with multiple poor prognostic factors. Therefore, it is crucial to consider not only the survival benefit, but also the minimization of treatment toxicity, and maximization of quality of life(QOL). | Naotake Tsuda Hidemichi Watari Kimio Ushijima | 2016 | Chinese Journal of Cancer Research2016，28，2： | 24 |
| 2 | 分型引物RT-PCR法在杯状病毒分子流行病学研究中的应用显示文摘目的:应用分型引物RT-PCR法确定五个地区病毒性腹泻粪便标本中杯状病毒流行型别及感染情况。方法:对五个地区收集的<5岁病毒性腹泻粪便标本应用针对病毒壳体区域设计的四对引物(GI-SKF/GI-SKR、COG2F/G2-SKR、SLV5317/SLV5749、PreCAP1/82b)进行反转录-聚合酶链反应(RT-PCR)扩增诺如病毒GI和GII组、扎如、星状病毒(Astrovirus),扩增产物通过1·5%琼脂糖凝胶电泳鉴定。选取部分阳性标本测序研究型别流行特点。结果:本实验从663例标本中共检出单独感染诺如病毒、扎如病毒和星状病毒阳性标本数分别为84、4、11株,同时还发现3株混合感染标本。选取24株诺如病毒阳性标本测序分析发现19株为GII/4型,2株为GII/3型,1株为GII/1型,1株为GII/13型,1株为GII/15型,4株扎如病毒中2株为SGI/1型,1株为SGII/3型,1株为SGII/1型。结论:研究表明杯状病毒是我国婴幼儿腹泻重要病原体,诺如病毒流行株为GII/4型毒株,同时存在其它型别的散在流行;福建、兰州检测到不同型别扎如病毒证明我国存在多种型别的扎如病毒感染。 | 孙亚萍 Hiroshi Ushijima 谢华萍 王慧 杜曾庆 金玉 何爱华 唐景裕 姬振周 方肇寅 | 2006 | 国际病毒学杂志2006，13，5： | 12 |
| 3 | study to determine guidelines for pediatric colonoscopy显示文摘AIM To investigated characteristics, diagnosis, bowelcleansing preparation, sedation, and colonoscope length and diameter in Japanese pediatric patients receiving total colonoscopy.METHODS The present study evaluated consecutive patients aged ≤ 15 years who had undergone their first colonoscopy in Kurume University between January 2007 and February 2015. Data were retrospectively analyzed. We identified 110 pediatric patients who had undergone colonoscopy that had reached the cecum, allowing the observation of the total colon.RESULTS Hematochezia, abdominal pain, and diarrhea were the most common symptoms. For bowel-cleansing preparation, pediatric patients aged ≤ 12 years were treated with magnesium citrate, and patients aged 13-15 years were treated with polyethylene glycol 4000. For sedation, thiamylal with pentazocine, which has an analgesic effect, was used in patients aged ≤ 6 years, and midazolam with pentazocine was used in patients aged ≥ 7 years. Regarding the choice of endoscope, short and thin endoscopes were selected for younger patients, particularly patients aged ≤ 3 years. Positive diagnoses were made in 78 patients(70.9%). Inflammatory bowel disease(n = 49, 44.5%), including ulcerative colitis(n = 37, 33.6%) and Crohn's disease(n = 12, 10.9%), was the most common diagnosis. CONCLUSION Colonoscopy offers a high diagnostic capability for pediatric patients with gastrointestinal symptoms. The selection of appropriate management the performance of colonoscopy is important in pediatric patients. | Shinichiro Yoshioka Hidetoshi Takedatsu Shuhei Fukunaga Kotaro Kuwaki Hiroshi Yamasaki RyosukeYamauchi Atsushi Mori Hiroshi Kawano Tadahiro Yanagi Tatsuki Mizuochi Kosuke Ushijima Keiichi Mitsuyama Osamu Tsuruta Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，31： | 10 |
| 4 | Imaging pitfalls of pancreatic serous cystic neoplasm and its potential mimickers显示文摘The aim of this article is to clarify diagnostic pitfalls of pancreatic serous cystic neoplasm(SCN) that may result in erroneous characterization. Usual and unusual imaging findings of SCN as well as potential SCN mimickers are presented. The diagnostic key of SCN is to look for a cluster of microcysts(honeycomb pattern), which may not be always found in the center. Fibrosis in SCN may be mistaken for a mural nodule of intraductal papillary mucinous neoplasm(IPMN). The absence of cyst wall enhancement may be helpful to distinguish SCN from mucinous cystic neoplasm. However, oligocystic SCN and branch duct type IPMN may morphologically overlap. In addition, solid serous adenoma, an extremely rare variant of SCN, is difficult to distinguish from neuroendocrine tumor. | Kousei Ishigami Akihiro Nishie Yoshiki Asayama Yasuhiro Ushijima Yukihisa Takayama Nobuhiro Fujita Shunichi Takahata Takao Ohtsuka Tetsuhide Ito Hisato Igarashi Shuji Ikari Catherine M Metz Hiroshi Honda | 2014 | World Journal of Radiology2014，6，3： | 6 |
| 5 | Numerical Study on Particle Motions in Swirling Flows in a Cyclone Separator显示文摘这研究的目的是在一个气旋隔板建立粒子分离的高度精确的预言方法。在一个气旋隔板的打漩的流动的数字模拟被基于一个 Smagorinsky 模型使用大旋涡模拟(LES ) 执行。模拟和复杂流动特征的有效性被比较与试验性的结果讨论。而且,粒子运动被一个 Lagrangian 方法对待并且与一个单程的方法被计算。为粒子分离的表演从跟踪的粒子的结果被预言。作为我们的调查的结果,为气旋隔板的粒子分离的表演上的插头管子的插入的高度的影响被显示出。关键词气旋隔板 - 打漩的流动 - 粒子运动 - 大旋涡模拟 CLC 数字 | Kazuyoshi MATSUZAKI Hideaki USHIJIMA Mizue MUNEKATA Hideki OHBA | 2006 | Journal of Thermal Science2006，15，2： | 3 |
| 6 | Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori -related gastritis显示文摘 | Takeichi Yoshida Jun Kato Takao Maekita Satoshi Yamashita Shotaro Enomoto Takayuki Ando Tohru Niwa Hisanobu Deguchi Kazuki Ueda Izumi Inoue Mikitaka Iguchi Hideyuki Tamai Toshikazu Ushijima Masao Ichinose | 2013 | Gastric Cancer2013，，4： | 3 |
| 7 | BRAF inhibitor:a novel therapy for ameloblastoma in mandible显示文摘Ameloblastoma is a benign but locally aggressive odontogenie neoplasm that accounts for 10% of all tumors arising in the mandible and maxilla (1).Eighty percent of ameloblastomas arise in the mandible,and they are usually found in young adults.It frequently recurs if not adequately resected.Therefore,the standard therapy for this tumor is complete bone resection with an adequate margin of safety: marginal or segmental osteotomy.However,aesthetic deformities,functional impairments and psychological impairments after radical surgery for large ameloblastoma, have been serious issues (1). | Masanobu Abe Liang Zong Takahiro Abe Hideyuki Takeshima Jiafu Ji Toshikazu Ushijima Kazuto Hoshi | 2018 | Chinese Journal of Cancer Research2018，30，6： | 3 |
| 8 | Image quality and diagnostic performance of free-breathing diffusion-weighted imaging for hepatocellular carcinoma显示文摘AIM To retrospectively evaluate the diagnostic performance of free-breathing diffusion-weighted imaging(FB-DWI) with modified imaging parameter settings for detecting hepatocellular carcinomas(HCCs).METHODS Fifty-one patients at risk for HCC were scanned with both FB-DWI and respiratory-triggered DWI with the navigator echo respiratory-triggering technique(RTDWI).Qualitatively,the sharpness of the liver contour,the image noise and the chemical shift artifacts on each DWI with b-values of 1000 s/mm2 were independently evaluated by three radiologists using 4-point scoring.Wecompared the image quality scores of each observer between the two DWI methods,using the Wilcoxon signed-rank test.Quantitatively,we compared the signal-to-noise ratios(SNRs) of the liver parenchyma and lesion-to-nonlesion contrast-to-noise ratios(CNRs) after measuring the signal intensity on each DWI with a b-factor of 1000 s/mm2.The average SNRs and CNRs between the two DWI methods were compared by the paired t-test.The detectability of HCC on each DWI was also analyzed by three radiologists.The detectability provided by the two DWI methods was compared using Mc Nemar's test.RESULTS For all observers,the averaged image quality scores of FB-DWI were:Sharpness of the liver contour [observer(Obs)-1,3.08 ± 0.81;Obs-2,2.98 ± 0.73;Obs-3,3.54 ± 0.75],those of the distortion(Obs-1,2.94 ± 0.50;Obs-2,2.71 ± 0.70;Obs-3,3.27 ± 0.53),and the chemical shift artifacts(Obs-1,3.38 ± 0.60;Obs-2,3.15 ± 1.07;Obs-3,3.21 ± 0.85).The averaged image quality scores of RTDWI were:Sharpness of the liver contour(Obs-1,2.33 ± 0.65;Obs-2,2.37 ± 0.74;Obs-3,2.75 ± 0.81),distortion(Obs-1,2.81 ± 0.56;Obs-2,2.25 ± 0.74;Obs-3,2.96 ± 0.71),and the chemical shift artifacts(Obs-1,2.92 ± 0.59;Obs-2,2.21 ± 0.85;Obs-3,2.77 ± 1.08).All image quality scores of FB-DWI were significantly higher than those of RT-DWI(P < 0.05).The average SNR of the normal liver parenchyma by FB-DWI(11.0 ± 4.8) was not significantly different from that shown by RT-DWI(11.0 ± 5.0);nor were the lesion-to-nonlesion CNRs significantly different(FB-DWI,21.4 ± 17.7;RT-DWI,20.1 ± 15.1).For all three observers,the detectability of FB-DWI(Obs-1,43.6%;Obs-2,53.6%;and Obs-3,45.0%) was significantly higher than that of RT-DWI(Obs-1,29.1%;Obs-2,43.6%;and Obs-3,34.5%)(P < 0.05).CONCLUSION FB-DWI showed better image quality and higher detectability of HCC compared to RT-DWI,without significantly reducing the SNRs of the liver parenchyma and lesionto-nonlesion CNRs. | Yukihisa Takayama Akihiro Nishie Yoshiki Asayama Kousei Ishigami Daisuke Kakihara Yasuhiro Ushijima Nobuhiro Fujita Ken Shirabe Atsushi Takemura Hiroshi Honda | 2017 | World Journal of Hepatology2017，9，14： | 3 |
| 9 | Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication显示文摘 | Takeshi Nakajima Shotaro Enomoto Satoshi Yamashita Takayuki Ando Yukihiro Nakanishi Kazuyuki Nakazawa Ichiro Oda Takuji Gotoda Toshikazu Ushijima | 2010 | Journal of Gastroenterology2010，，1： | 3 |
| 10 | Rescue case of low birth weight infant with acute hepatic failure显示文摘We report a case involving a rescued low birth weight infant(LBWI) with acute liver failure. Case: The patient was 1594 g and 32^(3/7) gestational wk at birth. At the age of 11 d, she developed acute liver failure due to gestational alloimmune liver disease. Exchange transfusion and high-dose gamma globulin therapy were initiated, and body weight increased with enteral nutrition. Exchange transfusion was performed a total of 33 times prior to living donor liver transplantation(LDLT). Her liver dysfunction could not be treated by medications alone. At 55 d old and a body weight of 2946 g, she underwent LDLT using an S2 monosegment graft from her mother. Three years have passed with no reports of intellectual disability or liver dysfunction. LBWIs with acute liver failure may be rescued by LDLT after body weight has increased to over 2500 g. | Noriki Okada Yukihiro Sanada Taizen Urahashi Yoshiyuki Ihara Naoya Yamada Yuta Hirata Takumi Katano Kentaro Ushijima Shinya Otomo Shujiro Fujita Koichi Mizuta | 2017 | World Journal of Gastroenterology2017，23，40： | 2 |
| 11 | Lagrangian and Eulerian Statistics from Direct Numerical Simulations of Turbulent Channel Flow显示文摘Lagrangian 和 Eulerian 统计从狂暴的隧道流动的直接数字的模拟被获得。雷纳兹数字被获得是重新字形物 = 100 (基于磨擦速度和隧道一半高度) 。微规模与 theirEulerian 等价物相比的 Lagrangian 时间。Lagrangian 预定微规模,被发现相等在墙的 Eulerian timemicroscales,但是他们比离开墙的 Eulerian 一致地大。TheEulerian 时间规模也被发现被繁殖速度而非吝啬的速度放大。到微规模被发现将近不变离开墙的 Eulerian 时间的 Lagrangian 的比率(y (+)> 40 ) 。 | 罗剑平 Tatsuo Ushijima Osami Kitoh | 2006 | Chinese Physics Letters2006，23，4： | 2 |
| 12 | Inflammation-Associated Cancer Development in Digestive Organs: Mechanisms and Roles for Genetic and Epigenetic Modulation显示文摘 | Tsutomu Chiba Hiroyuki Marusawa Toshikazu Ushijima | 2012 | Gastroenterology2012，，3： | 2 |
| 13 | Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study显示文摘 | Shimazu Taichi Asada Kiyoshi Charvat Hadrien Kusano Chika Otake Yosuke Kakugawa Yasuo Watanabe Hidenobu Gotoda Takuji Ushijima Toshikazu Tsugane Shoichiro | 2015 | Carcinogenesis2015，，： | 2 |
| 14 | 在 transcatheter 以后的征兆的 arterioportal 管的临床的结果动脉的 embolization显示文摘 AIM: To evaluate the complications and clinical outcomes of transcatheter arterial embolization (TAE) for symptoms related to severe arterioportal fistulas (APFs). METHODS: Six patients (3 males, 3 females; mean age, 63.8 years; age range, 60-71 years) with chronic liver disease and severe APFs due to percutaneous intrahepatic treatment (n=5) and portal vein (PV) tumor thrombosis of hepatocellular carcinoma (n=1) underwent TAE for symptoms related to severe APFs [refractory ascites (n=4), hemorrhoidal hemorrhage (n=1), and hepatic encephalopathy (n=1)]. Control of symptoms related to APFs and complications were evaluated during the follow-up period (range, 4-57 mo). RESULTS: In all patients, celiac angiography revealed immediate retrograde visualization of the main PV before TAE, indicating severe APF. Selective TAE for the hepatic arteries was performed using metallic coils (MC, n=4) and both MCs and n-butyl cyanoacrylate (n=2). Three patients underwent repeated TAEs for residual APFs and ascites. Four patients developed PV thrombosis after TAE. During the follow-up period after TAE, APF obliteration and symptomatic improvement were obtained in all patients. CONCLUSION: Although TAE for severe APFs may sometimes be complicated by PV thrombosis, TAE can be an effective treatment to improve clinical symptoms related to severe APFs. | Masakazu Hirakawa Akihiro Nishie Yoshiki Asayama Kousei Ishigami Yasuhiro Ushijima Nobuhiro Fujita Hiroshi Honda | 2013 | World Journal of Radiology2013，5，2： | 2 |
| 15 | Propagation of Weak Pressure Waves against Two Parallel Subsonic Streams显示文摘在这份报纸,在经常区域的直管对二条平行亚声的溪流宣传的一个压力波浪的特征被一个维的分析,二维的数字模拟,和实验调查。计算被二维的 Euler 方程用 Chakravarthy-Osher-type TVD 计划执行了。由象墙压力大小一样的 schlieren 方法的光观察被执行了澄清结构和压力波浪的繁殖速度。对溪流宣传的压力波浪变成一个区分的压力波浪和分叉的结果表演发生在低速度溪流。分析和计算获得的压力波浪的繁殖速度与现在的试验性的数据同意很好,这也被发现。关键词可压缩的流动 - 流动可视化 - 内部流动 - 化合物飘动 - 复合窒息的 CLC 数字 O354. | Makiko YONAMINE Takanori USHIJIMA Yoshiaki MIYAZATO Mitsuharu MASUDA Hiroshi KATANODA Kazuyasu MATSUO | 2006 | Journal of Thermal Science2006，15，2： | 2 |
| 16 | Genetic and epigenetic alterations in carcinogenesis 显示文摘 | Ushijima T | 2000 | Mutation Res2000，462，2： | 1 |
| 17 | DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers显示文摘 | Ushijima S Kondo Y | 2001 | Int J Cancer2001，91，2： | 1 |
| 18 | Cloning and characterization of cDNAs encoding S-RNases from almond (Prunus dulcis):primary structural features and sequence diversity of the S-RNases in Rosaceae显示文摘 | Ushijima K Sassa H Tao R | 1998 | Molecular and General Genetics1998，260，： | 1 |
| 19 | Intrapleural hypotonic cispl- atin treatment for malignant pleural effusion in 80 patients with non - small - cell lung cancer:a multi - institutional phase II trial显示文摘 | T Seto S Ushijima H Yamamoto | 2006 | Br J Cancer2006，95，6： | 1 |
| 20 | Genotype C of hepatitis B virus can be classified into at least two subgroups显示文摘 | Huy TT Ushijima H Quang VX | 2004 | J Gen Virel2004，85，2： | 1 |
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