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| 1 | Retroperitoneal fibrosis associated with immunoglobulin G4-related disease显示文摘Retroperitoneal fibrosis is a rare disease characterized by the development of inflammation and fibrosis in the soft tissues of the retroperitoneum and other abdominal organs.Retroperitoneal fibrosis can be of 2 types:idiopathic and secondary.The recently advocated concept and diagnostic criteria of immunoglobulin G4(IgG4)-related disease,derived from research on autoimmune pancreatitis(AIP),has led to widespread recognition of retroperitoneal fibrosis as a condition caused by IgG4-related disease.We now know that previously diagnosed idiopathic retroperitoneal fibrosis includes IgG4-related disease;however,the actual prevalence is unclear.Conversely,some reports on AIP suggest that retroperitoneal fibrosis is concurrently found in about 10% of IgG4-related disease.Because retroperitoneal fibrosis has no specific symptoms,diagnosis is primarily based on diagnostic imaging(computed tomography and magnetic resonance imaging),which is also useful in evaluating the effect of therapy.Idiopathic retroperitoneal fibrosis can occur at different times with other lesions of IgG4-related disease including AIP.Thus,the IgG4 assay is recommended to diagnose idiopathic retroperitoneal fibrosis.High serum IgG4 levels should be treated and monitored as a symptom of IgG4-related disease.The first line of treatment for retroperitoneal fibrosis is steroid therapy regardless of its cause.For patients with concurrent AIP,i.e.,IgG4-related retroperitoneal fibrosis,the starting dose of steroid is usually 30-40 mg/d.The response to steroid therapy is generally favorable.In most cases,the pancreatic lesion and retroperitoneal fibrosis improve after the initial treatment.However,the epidemiology,treatment for recurring retroperitoneal fibrosis,and long-term prognosis are still largely unknown.Further analysis of such cases and research are necessary. | Nao Fujimori Tetsuhide Ito Hisato Igarashi Takamasa Oono Taichi Nakamura Yusuke Niina Masayuki Hijioka Lingaku Lee Masahiko Uchida Ryoichi Takayanagi | 2013 | World Journal of Gastroenterology2013，19，1： | 14 |
| 2 | High circulating tumor cell concentrations in a specific subtype of gastric cancer with diffuse bone metastasis at diagnosis显示文摘AIM: To clarify the biological feature contributing to gastric cancer with diffuse bone metastases at diagnosis.METHODS: The participants visited the Department of Clinical Oncology, Akita University Hospital, from January 2014 to August 2015. The selection criterion for gastric cancer with diffuse bone metastases at diagnosis includes over 29 hot spots of bone scintigraphy. Circulating tumor cell were collected from 20 m L of peripheral venous blood drawn using a Cell Search kit and a Cell Tracks Auto Prep system by SRL, a clinical laboratory. The endpoints of this study were correlations between circulating tumor cells(CTC) count and therapeutic outcomes. RESULTS: Among 39 patients with gastric cancer, 5 patients met the criterion. The incidence of this subtype was 12.8%. CTC counts ranged from 235 to 6440 cells/7.5 m L of peripheral blood(median of 1724). These values were much higher than common gastric cancers(2 cells). In chemo-sensitive cases, CTC counts decreased within 14 d(median) from 275, 235 and 1724 to 2, 7 and 66, respectively. On the other hand, CTC counts increased after treatment failure or insensitive case from 2, 7 and 6440 to 787, 513 and 7885, respectively. The correlation between CTC count and survival time showed a trend, but did not reach significance(Y = 234.6- 0.03 X, P = 0.085).CONCLUSION: High CTC count is a biological hallmark of this subtype, and can be used as a direct and definitive indicator of therapeutic outcome. | Kazuhiro Shimazu Koji Fukuda Taichi Yoshida Masahiro Inoue Hiroyuki Shibata | 2016 | World Journal of Gastroenterology2016，22，26： | 9 |
| 3 | Endoscopic approach through the minor papilla for the management of pancreatic diseases显示文摘AIM:To clarify the efficacy and safety of an endoscopic approach through the minor papilla for the management of pancreatic diseases.METHODS:This study included 44 endoscopic retrograde cholangiopancreatography(ERCP) procedures performed in 34 patients using a minor papilla approach between April 2007 and March 2012.We retrospectively evaluated the clinical profiles of the patients,the endoscopic interventions,short-term outcomes,and complications.RESULTS:Of 44 ERCPs,26 were diagnostic ERCP,and 18 were therapeutic ERCP.The most common cause of difficult access to the main pancreatic duct through the major papilla was pancreas divisum followed by distortion of Wirsung's duct.The overall success rate of minor papilla cannulation was 80%(35/44),which was significantly improved by wire-guided cannulation(P = 0.04).Endoscopic minor papillotomy(EMP) was performed in 17 of 34 patients(50%) using a needle-knife(13/17) or a pull-type papillotome(4/17).EMP with pancreatic stent placement,which was the main therapeutic option for patients with chronic pancreatitis,recurrent acute pancreatitis,and pancreatic pseudocyst,resulted in short-term clinical improvement in 83% of patients.Mild post-ERCP pancreatitis occurred as an early complication in 2 cases(4.5%).CONCLUSION:The endoscopic minor papilla approach is technically feasible,safe,and effective when the procedure is performed in a high-volume referral center by experienced endoscopists. | Nao Fujimori Hisato Igarashi Akira Asou Ken Kawabe Lingaku Lee Takamasa Oono Taichi Nakamura Yusuke Niina Masayuki Hijioka Masahiko Uchida Kazuhiro Kotoh Kazuhiko Nakamura Tetsuhide Ito Ryoichi Takayanagi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 6 |
| 4 | Fractalkine and TGF-β1 levels reflect the severity of chronic pancreatitis in humans显示文摘AIM: To clarify whether serum chemokine and cytokine levels can become useful biological and functional markers to assess the severity of chronic pancreatitis (CP). This study aimed at clarifying whether serum chemokine and cytokine levels can become useful biological and functional markers to assess the severity of CP. METHODS: Serum monocyte chemoattractant protein-1 (MCP-1), transforming growth factor beta-1 (TGF-β1), and soluble type fractalkine (s-fractalkine) concentrations were examined in patients with CP (n = 109) and healthy controls (n = 116). Severity of disease was classified in patients with CP by a staging system. Relationships between stage-specifi c various clinical factors and serum MCP-1, TGF-β1, and s-fractalkine levels were investigated. Furthermore, 57 patients with non-alcoholic CP were similarly evaluated in order to exclude in? uence of alcohol intake. RESULTS: Patients with CP showed signifi cant higher levels of serum TGF-β1 and s-fractalkine, but not MCP-1, compared to the controls. Serum TGF-β1 in the severe stage and s-fractalkine in the mild and thesevere stage of CP significantly increased compared to those of controls. However, it was observed that both TGF-β1 and s-fractalkine levels were affected by alcohol intake. In patients with non-alcoholic CP, serum TGF-β1 showed significant increase in the moderate stage of CP, and serum s-fractalkine revealed signifi cant increase in the early stage of CP. CONCLUSION: It is suggested that the measurement of serum F-fractalkine is useful to diagnose early-stage CP. Moreover, the combined determination of both, s-fractalkine and TGF-β1, in human sera may be helpful in evaluating the severity status of CP. | Mikihiko Yasuda Tetsuhide Ito Takamasa Oono Ken Kawabe Toyoma Kaku Hisato Igarashi Taichi Nakamura Ryoichi Takayanagi | 2008 | World Journal of Gastroenterology2008，14，42： | 4 |
| 5 | Innovative treatment system for digester liquor using anammox process显示文摘 | Kenji Furukawa Yasuhiko Inatomi Sen Qiao Lai Quan Taichi Yamamoto Kazuichi Isaka Tatsuo Sumino | 2008 | Bioresource Technology2008，，22： | 2 |
| 6 | Catalyst-free growth of ZnO nanowires on various-oriented sapphire substrates by pulsed-laser deposition显示文摘Catalyst-free growth of one-dimensional zinc oxide(ZnO) nanowires is reported. ZnO nanowires were synthesized on ZnO buffer layers deposited on various-oriented sapphire substrates. Syntheses of ZnO buffer layers and nanowires were performed by ultraviolet pulsed-laser deposition. ZnO nanowire's number density was the lowest in the case of using m-cut sapphire substrates. ZnO nanowires grown on a-cut sapphire substrates had vertical alignment with distances of tens to hundreds of nanometers. On the other hand, ZnO nanowires grown on c-cut sapphire substrates had the biggest nucleation rate. The dependence of crystalline orientation of ZnO buffer layers on the orientation of sapphire substrates were investigated by electron back scatter diffraction measurement.From their results, the growth models of ZnO buffer layers were suggested and the variations in morphological properties of ZnO nanowires were discussed. | Tetsuya Shimogaki Masahiro Takahashi Masaaki Yamasaki Taichi Fukuda Mitsuhiro Higashihata Hiroshi Ikenoue Daisuke Nakamura Tatsuo Okada | 2016 | Journal of Semiconductors2016，37，2： | 2 |
| 7 | Consumption of n-3 Fatty Acids and Fish Reduces Risk of Hepatocellular Carcinoma显示文摘 | Norie Sawada Manami Inoue Motoki Iwasaki Shizuka Sasazuki Taichi Shimazu Taiki Yamaji Ribeka Takachi Yasuhito Tanaka Masashi Mizokami Shoichiro Tsugane | 2012 | Gastroenterology2012，，7： | 2 |
| 8 | Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study显示文摘 | Shimazu Taichi Asada Kiyoshi Charvat Hadrien Kusano Chika Otake Yosuke Kakugawa Yasuo Watanabe Hidenobu Gotoda Takuji Ushijima Toshikazu Tsugane Shoichiro | 2015 | Carcinogenesis2015，，： | 2 |
| 9 | Hepatocellular Carcinoma Arising from Nonalcoholic Steatohepatitis: Report of Two Cases显示文摘 | Seikan Hai Shoji Kubo Taichi Shuto Hiromu Tanaka Shigekazu Takemura Takatsugu Yamamoto Akishige Kanazawa Masao Ogawa Kazuhiro Hirohashi Kenichi Wakasa | 2006 | Surgery Today2006，，4： | 2 |
| 10 | 用中性有机磷类化合物和高分子量的胺类萃取剂从盐酸溶液中萃取铼(Ⅶ)显示文摘研究了用两种中性有机磷类比合物——磷酸三了脂(TBP)和三辛基氧膦(TOPC)以及两种高分子量的胺类萃取剂——三辛胺(TCA)和三辛基甲基氯化铵(TOMAC)从盐酸溶液中萃取铼(Ⅶ)。试验结果表明,TBP,TOPO,TOA,TOMAC的萃取平衡可以表示为:ReO_3Cl有十nS_有 ReO_3ClnS有,式中,n=4和2(分别对S=TBP和TOPO而言);HReO_4水十R_3NHCl有 R_3NH_2ReO_4Cl有(对TOA而言);ReO_4-水十R_3R′NCl有 R_3R′NReO_4有十C1-水(对TOMAC而言)。在上述萃取体系中,铼(Ⅷ)的萃取率按下列顺序递减。在低酸度下:TOA>TOMAC>TOPO>TBP,在较高的酸度下:TOMAC>TOA>TOPO>TBP。 | Taichi Sato 聂国林 | 1992 | 湿法冶金1992，11，1： | 2 |
| 11 | Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice显示文摘 | Fumitake Usui Hiroaki Kimura Taichi Ohshiro Kazuki Tatsumi Akira Kawashima Akiyo Nishiyama Yo-ichiro Iwakura Shun Ishibashi Masafumi Takahashi | 2012 | Biochemical and Biophysical Research Communications2012，，1： | 2 |
| 12 | Promoter hypomethylation regulates CD133 expression in human gliomas显示文摘大脑开始肿瘤的房间(BTIC ) 对房间表面蛋白质 CD133 用抗体被充实;然而,生物关联和在人的 gliomas 的 CD133 表示的规章的机制还没被理解。在这研究,我们开始证明 CD133 是在 CD133 积极的房间焦点地作为在哪儿被观察的高级人的 glioblastomas 的 overexpressed 一微簇。另外,有 exon 1A, 1B,或 1C 的 CD133 抄本主要在 glioblastomas 被表示。阐明调整 CD133 的这异常表情的机制,包含一个 CpG 岛的三个近似倡导者(P1, P2,和 P3 ) 被孤立。在 U251MG 和 T98G glioblastoma 房间, P1 区域 flanking exon 1A 在三个倡导者之中展出了最高的活动,并且这项活动显著地被使失去活性由在 vitro methylation。在有 demethylating 代理人 5-azacytidine 或 histone deacetylase 禁止者 valproic 酸的处理以后, CD133 mRNA 的表示水平显著地在 glioma 房间被恢复。重要地,在 P1, P2,和 P3 区域以内的 CpG 地点的 hypomethylation 被与丰富的 CD133 mRNA 在人的 glioblastoma 纸巾定序的重亚硫酸盐观察。一起拿,我们的结果显示 DNA hypomethylation 是在 glioblastomas 的 CD133 表示的一个重要决定因素,并且这个 epigenetic 事件可以与表示 CD133 的 BTIC 的发展被联系。 | Kouichi Tabu Ken Sasail Taichi Kimura Lei Wang Eiko Aoyanagil Shinji Kohsaka Mishie Tanino Hiroshi Nishihara Shinya Tanaka | 2008 | Cell Research2008，18，10： | 2 |
| 13 | EFFICACY OF PROCALCITONIN IN THE EARLY DIAGNOSIS OF BACTERIAL INFECTIONS IN A CRITICAL CARE UNIT显示文摘 | Akiko Nakamura Hideo Wada Makoto Ikejiri Tsuyoshi Hatada Hiroyuki Sakurai Yoshiko Matsushima Junji Nishioka Kazuo Maruyama Shuji Isaji Taichi Takeda Tsutomu Nobori | 2009 | Shock2009，，6： | 2 |
| 14 | The Z-phase in 9–12% Cr ferritic steels: A phase stability analysis显示文摘 | Cenk Kocer Taichi Abe Aloysius Soon | 2008 | Materials Science & Engineering A2008，，1： | 1 |
| 15 | Influence of histological inflammatory activity on regenerative capacity of liver after percutaneous transhepatic portal vein embolization显示文摘 | Hiromu Tanaka Kazuhiro Hirohashi Shoji Kubo Takashi Ikebe Tadashi Tsukamoto Hiroyuki Hamba Taichi Shuto Kenichi Wakasa Hiroaki Kinoshita | 1999 | Journal of Gastroenterology1999，，1： | 1 |
| 16 | Long-term stability of partial nitritation of swine wastewater digester liquor and its subsequent treatment by Anammox 显示文摘 | Taichi Y Keita T Toichiro K | 2008 | Bioresource Technology2008，99，： | 1 |
| 17 | Partial nitritation treat- ment of underground brine waste with high ammonium and salt content显示文摘 | Takehiko S Sen Q Taichi Y | 2009 | Journal of Bioscience and Bioengineering2009，108，4： | 1 |
| 18 | Time-Space Trend Analysis in Pan Evaporation over Kingdom of Thailand显示文摘 | Taichi Tebakari | 2005 | Journal of Hydrologic Engineering2005，10，3： | 1 |
| 19 | Studies on the sesquiterpenes from Ambrosia elatior Linn6 显示文摘 | Taichi O Keiji I Sachiyo N | 1987 | Chem Pharm Bull1987，35，6： | 1 |
| 20 | Synthesis ofrhodamine B-doped and monodispersed spherical particles of polyorganosiloxane using a W/O emulsion显示文摘 | TAICHI M YASUSHI T HIROAKI O | 2005 | Journal of the American Ceramic Society2005，88，12： | 1 |
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