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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | The determinants of right ventricular function in patients with atrial septal defect显示文摘 | Gorgulu S Eren M Uslu N | 2006 | Int J Cardiol2006，111，： | 1 |
| 3 | Longitudinal left ventricular systolic function is impaired in patients with coronary slow flow显示文摘 | Nurkalem Z Gorgulu S Uslu N | | 0，，： | 1 |
| 4 | Acute liver failure in children: 20-year experience显示文摘 | Baris Z Saltik TIN Uslu N | 2012 | Turk J Gastroen terol2012，23，2： | 1 |
| 5 | Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus显示文摘 | Uslu S Kebapci N Kara M | 2012 | Exp Ther Med2012，4，1： | 1 |
| 6 | Longitudinal left ventricular systolic function is impaired in patients with coronary slow flow显示文摘 | Nurkalem Z Gorgulu S Uslu N | | 0，，01： | 1 |
| 7 | Longitudinal left ventrieular sys- tolic runetion is impaired in patients with corollary slow flow显示文摘 | Nurkalem Z Gorgulu S Uslu N | 2009 | Int J Cardiovase Imaging2009，25，： | 1 |
| 8 | Resistance of Dasypyrum villosum to the cereal eyespot pathogens, Tapesia yallundae and Tapesia acuformis显示文摘 | USLU E MILLER T E REZANOOR N H | 1998 | Euphytica1998，103，2： | 1 |
| 9 | Left ventricular diastolic function and endothelial function in patients with erectile dysfunction 显示文摘 | Uslu N Eren M Gorgulu S | 2006 | Am J Cardiol2006，97，12： | 1 |
| 10 | Acute liver failure in children: 20-year experience 显示文摘 | Baris Z Saltik Temzel IN Uslu N | 2012 | Turk J Gastroenterol2012，23，2： | 1 |
| 11 | Volume measurement by computed tomography in auxiliary heterotopic partial liver transplant recipients:follow-up results显示文摘 | Tarhan NC Uslu Tutar N Yolog ˇlu Z | 2000 | Transplant Proc2000，32，3： | 1 |
| 12 | Predicting breast attenuation in patients undergoing myocardial perfusion scintigraphy:a digital x-ray study显示文摘 | Nurkalem Z Sahin S Uslu N | | 0，，： | 1 |
| 13 | 查看详情显示文摘 | Makal U Uslu N Wynne K.J | | 0，，： | 1 |
| 14 | Resistance of Dasypyrum villosum to the cereal eyespot pathogens, Tapesia yaUundae and Tapesia acuformis 显示文摘 | Uslu E Miller T E Rezanoor N H | 1998 | Euphytica1998，103，2： | 1 |
| 15 | Relation between aortic stiff-ness and left ventricular diastolic function in patients with hyperten-sion ,diabetes, or both显示文摘 | 'Eren M Gorgulu S Uslu N | 2004 | Heart2004，90，1： | 1 |
| 16 | Thyroid perox idase gene mutations causing congen ital hypothyroid ism in three Turkish families显示文摘 | Ozbek MN Uslu AB Onen li Mungan N | 2009 | J Ped iatr Endocrinol Metab2009，22，11： | 1 |
| 17 | Longitudinal left ventricu-lar systolic function is impaired in patients with coronary slow flow显示文摘 | Nurkalem Z Gorgulu S Uslu N | | 0，，1： | 1 |
| 18 | Acne: prevalence, perceptions and effects on psychological health among adolescents in Aydin, Turkey显示文摘 | Uslu G Sendur N Uslu M | 2008 | J Eur Acad Dermatol Venereol2008，22，4： | 1 |
| 19 | Double heterotopic pancreas and meckel 's diverticulum in a child:do they have a common origin? 显示文摘 | BAYSOY G BALAMTEKIN N USLU N | 2010 | Turk J Pediatr2010，2，3： | 1 |
| 20 | Longitudinal left ventricular systolic function is impaired in patients with coronary slow flow显示文摘 | Nurkalem Z Gorgulu S Uslu N | 2009 | Int J Cardiovasc Imaging2009，25，1： | 1 |
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