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| 1 | Cyclosporine A, FK-506, 40-0-[2-hydroxyethyl]rapamycin and mycophenolate mofetil inhibit proliferation of human intrahepatic biliary epithelial cells in vitro显示文摘瞄准:调查 cyclosporine 的效果 A (CsA )(MMF ) , FK-506,和 mycophenolate mofetil 和 40-0-[2-hydroxyethyl ] 人的肝内的增长上的 rapamycin (RAD ) 胆汁的上皮细胞(BEC ) 在试管内。方法:BEC 与免疫从六个人的肝织物标本被孤立磁性的分离方法并且与 CsA, FK-506, RAD,和 MMF 在试管内的不同集中对待。房间的增长被 MTT 试金分别地在 24 和 48 h 术后疗法测量。变化的单程的分析被用来分析结果。在 BEC 的 CK 19 的表示被流动血细胞计数和西方的污点监视。结果:BEC 的六根线被建立。他们为 4-18 wk 在试管内幸存。流动血细胞计数分析证明这些房间总是表示了 CK19。CsA, FK-506, RAD,和 MMF 以一种剂量依赖者方式禁止了 BEC 的增长。禁止 BEC (P<0.05 ) 的增长的 CsA, FK-506, RAD,和 MMF 的最低集中分别地是 500, 100, 0.25,和 100 mug/L。然而,由 BEC 的 CK19 的表示没被改变。结论:CsA, FK-506, RAD,和 MMF 在人的肝内 BEC 在试管内上有 antiproliferative 效果,当 RAD 有最强壮的生长禁止的效果时。他们在 transplant 病人的肝新生和胆汁管损害上的可能的效果应该进一步被调查。 | Chao Liu Thomas Schreiter Andrea Frilling Uta Dahmen Christoph E Broelsch Guido Gerken Ulrich Treichel | 2005 | World Journal of Gastroenterology2005，11，48： | 7 |
| 2 | Volatile composition,emission pattern,and localization of floral scent emission in Mirabilis jalapa(Nyctaginaceae)显示文摘 | UTA E J ANA G URSULAS R R | 2005 | American Journal of Botany2005，92，1： | 1 |
| 3 | Nanostrutured composite materials with improved deformation behavior显示文摘 | JuRGEN E UTA K JAYANTA D SERGIO S N1COLLE R | 2005 | Advanced Engineering Materials2005，7，7： | 1 |
| 4 | Neoadjuvant chemoradiotherapy for esophageal cancer:Impact on extracapsular lymph node involvement显示文摘AIM:To assess the effects of neoadjuvant chemoradiotherapy(CRT) on the presence of extracapsular lymph node involvement(LNI) and its prognostic value in patients with resected esophageal cancer.METHODS:Two hundred and ninety-eight patients with advanced esophageal cancer underwent esophagectomy between 1997 and 2006.One hundred and ninety patients(63.8%) were treated with neoadjuvant CRT prior to resection.A total of 986 metastatic LNs were examined.Survival of the patients was analyzed according to intra-and extra-capsular LNI.RESULTS:Five-year survival rate was 22.5% for the entire patient population.Patients with extracapsular LNI had a 5-year survival rate of 16.7%,which was comparable to the 15.8% in patients with infiltrated nodes of the celiac trunk(pM1lymph).In contrast to patients treated with surgery alone,neoadjuvant therapy resulted in signif icantly(P = 0.001) more patients with pN0/M0(51.6% vs 25.0%).In 17.6% of the patients with surgery alone vs 16.8% with neoadjuvant CRT,extracapsular LNI was detected.Neoadjuvant therapy does not reduce the occurrence of extracapsular LNI.CONCLUSION:Extracapsular LNI is an independent negative prognostic factor not influenced by neoadjuvant CRT.In a revised staging system for esophageal cancer,extracapsular LNI should be considered. | Ralf Metzger Elfriede Bollschweiler Uta Drebber Stefan P Mnig Wolfgang Schrder Hakan Alakus Martin Kocher Stephan E Baldus Arnulf H Hlscher | 2010 | World Journal of Gastroenterology2010，16，16： | 1 |
| 5 | Schlange, 1996, A network approach to strategy显示文摘 | Uta Juttner Lutz E | 1996 | International Journal of Research in Marketing1996，13，： | 1 |
| 6 | TRPAl-expressing primary afferents synapse with a morphologically identified Subclass of substantia gelatinosa neurons in the adult rat spinal cord显示文摘 | UTA D FURUE H PICKERING A E | 2010 | The European Journal of Neuro- science2010，31，11： | 1 |
| 7 | Mitochondrial dysfunction,apoptotie cell death,and Alzheimer's disease显示文摘 | Anne E Uta K Celio A | 2003 | Biochem Pharmacol2003，66，： | 1 |
| 8 | Systemicdexmedetomidine augments inhibitory synaptic transmissionin the superficial dorsal horn through activation ofdescending noradrenergic control;an in vivo patch-clampanalysis of analgesic mechanisms显示文摘 | FUNAI Y PICKERING A E UTA D | 2014 | Pain2014，155，3： | 1 |
| 9 | - irrigated pressure drop liquid holdup, and packing fractional wetted area显示文摘 | IL/UTA I LARACHI E Mechanistic model for columns | 2001 | Industrial & Engineering Chemistry Research2001，40，23： | 1 |
| 10 | Nanostructured composite materials with improved deformation behavior显示文摘 | JURGEN E UTA K JAYANTA D SERGIO S NICOLLE R | 2005 | Advanced Engineering Materials2005，7，7： | 1 |
| 11 | Pentylenetetazole(PTZ) inuced c- fos expression in the hippocampus of kindled rats is suppressed by concomitant treatment with treatment with naloxione显示文摘 | Martina E V Uta R | 1998 | Brain /~es1998，792，2： | 1 |
| 12 | RNAi-mediated knock-down of Dab and Numb attenuate Ab levels via g-secretase mediated APP processing显示文摘Amyloid-b-protein(Ab),the key component of senile plaques in Alzheimer’s disease(AD)brain,is produced from amyloid precursor protein(APP)by cleavage of b-secretase and then g-secretase.APP adaptor proteins with phosphotyrosine-binding(PTB)domains,including Dab(gene:DAB)and Numb(gene:NUMB),can bind to and interact with the conserved YENPTY-motif in the APP C-terminus.Here we describe,for the first time,the effects of RNAi knock-down of Dab and Numb expression on APP processing and Ab production.RNAi knock-down of Dab and Numb in H4 human neuroglioma cells stably transfected to express either FL-APP(H4-FL-APP cells)or APP-C99(H4-APP-C99 cells)increased levels of APP-C-terminal fragments(APP-CTFs)and lowered Ab levels in both cell lines by inhibiting g-secretase cleavage of APP.Finally,RNAi knock-down of APP also reduced levels of Numb in H4-APP cells.These findings suggest that pharmacologically blocking interaction of APP with Dab and Numb may provide novel therapeutic strategies of AD.The notion of attenuating g-secretase cleavage of APP via the APP adaptor proteins,Dab and Numb,is particularly attractive with regard to therapeutic potential,given that side effects of gsecretase inhibition owing to impaired proteolysis of other g-secretase substrates,e.g.Notch,might be avoided. | Zhongcong Xie Yuanlin Dong Uta Maeda Weiming Xia Rudolph E Tanzi | 2012 | Translational Neurodegeneration2012，1，1： | 0 |
| 13 | Administration of granulocyte colony stimulating factor after liver transplantation leads to an increased incidence and severity of ischemic biliary lesions in the rat model显示文摘瞄准:最近,粒细胞殖民地刺激因素(G-CSF ) 罐头在健康骨髓施主导致 hypercoagulability,这被报导了。prothrombotic 的正式就职与已经损害的灌注在机关接枝的一个接受者声明原因可能在移植机关推进恶化,是想得到的。这研究评估了 G-CSF 治疗是否变得更坏在老鼠的肝灌注追随者肝移植当模特儿。方法:一个化为动脉血得非的老鼠肝移植模特儿被雇用在 syngeneic 和 allogeneic 紧张联合在肝上评估 G-CSF 治疗的效果。学习结果包括了由肝酶和肝组织学调查了的生存时间和肝损坏。观察时间是 1 d, 1 wk 和 12 wk。结果:与 G-CSF 对待的老鼠增加了胆汁的损坏追随者肝移植的发生和严厉。在这些动物,肝细胞坏死在小叶中心区域被加重。这些损害在 G-CSF 的损害灌注是指示的对待的动物。结论:当治疗可能提高先存在的、未被发现的灌注问题并且最终导致局部缺血, G-CSF 应该在肝移植的接受者小心地被使用导致的胆汁的复杂并发症。 | Olaf Dirsch Haidong Chi Yuan Ji Yan Li Gu Christoph E Broelsch Uta Dahmen | 2006 | World Journal of Gastroenterology2006，12，31： | 0 |
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