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| 1 | Lactobacilli,bifi dobacteria and E.coli nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells显示文摘AIM: To investigate whether the stimulation of peripher- al blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specifi c. METHODS: Three strains of bifi dobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centri- fuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 102 to 108 CFU/mL. Cell supernatants were taken and interleukin (IL)-10, IL-1β, and tumor necosis factor (TNF)-α were determined by ELISA. RESULTS: Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bifidobacteriaand lactobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had simi- lar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifi dobacteria and lactobacilli. The cell debris of bifi dobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentra- tions were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION: The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specifi c reactions. High IL-10 response to cell de- bris of bifi dobacteria and E. coli nissle can be found. This corresponds to positive effects of bifi dobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactoba- cilli. | Ulf Helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 2 | A novel surgical procedure for bridging of massive bone defects显示文摘 | Ulf R Knothe Dempsey S Springfield | 2005 | World Journal of Surgical Oncology2005，3，7： | 1 |
| 3 | Temporal trends in Deep Ocean Redfield Ratios显示文摘 | Markus P Ulf R | 2000 | Science2000，289，： | 1 |
| 4 | Diagnostic and prognostic role of biomarkers for pulmonary hypertension in interstitial lung disease显示文摘 | Charlotte U. Andersen S?ren Mellemkj?r Jens Erik Nielsen-Kudsk Elisabeth Bendstrup Ulf Simonsen Ole Hilberg | 2012 | Respiratory Medicine2012，，12： | 1 |
| 5 | Reoperation After Recurrent Groin Hernia Repair显示文摘 | Staffan Haapaniemi Ulf Gunnarsson P?r Nordin Erik Nilsson | 2001 | Annals of Surgery2001，，1： | 1 |
| 6 | Inactivation of Escherichia Coli, Listeria Innocua and Saccharomyces Cerevisiae in Relation to Membrane Permeabilization and Subsequent Leakage of Intracellular Compounds due to Pulsed Electric Field Processing显示文摘 | KRISTINA A ULF R ELISABETH B | 2005 | International Journal of Food Microbiology2005，，99： | 1 |
| 7 | Reoperation After Recurrent Groin Hernia Repair显示文摘 | Staffan Haapaniemi Ulf Gunnarsson P?r Nordin Erik Nilsson | 2001 | Annals of Surgery2001，，1： | 1 |
| 8 | 查看详情显示文摘 | Ulf Panzer Rudiger R | | 0，，： | 1 |
| 9 | T cells induce terminal differentiation of transformed B cells to mature plasma cell tumors 显示文摘 | Ming Y S Ulf R R | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 10 | Breakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanisms显示文摘 | Kristina B. Svendsen Steen Andersen Sigurdur Arnason Staffan Arnér Harald Breivik Tarja Heiskanen Eija Kalso Ulf E. Kongsgaard Per Sjogren Peter Strang Flemming W. Bach Troels S. Jensen | 2004 | European Journal of Pain2004，，2： | 1 |
| 11 | Effects of sewage- derived nutrients on an estuarine macrobenthie community显示文摘 | Savage C Elmgren R Larsson Ulf | 2002 | Marine Ecology Progress Series2002，243，： | 1 |
| 12 | Conges- tion charges and retail revenues: Results from the Stockholm road pricing trial 显示文摘 | Sven - Olov Daunfeldt Niklas Rudholm Ulf R~imme | 2009 | Transportation Research Part A2009，，3： | 1 |
| 13 | Assessing Physical Activity Using Wearable Monitors Meas- ures of Physical Activity 显示文摘 | Nancy F Butte Ulf Ekelund Klaas R | 2012 | MEDICINE AND SCIENCE IN SPORTS AND EXERCISE2012，44，12： | 1 |
| 14 | Multivariate analysis of exhaust emissions from heavy-duty diesel fuels显示文摘 | MICHAEL S HANG Li ULF R | 1996 | Environ Sei Teehnol1996，30，： | 1 |
| 15 | Inactivation ofEscherichia Coli,Listeria Innocua and Saccharomyces Cerevisiaein relation to membrane permeabilization and subsequentleakage of intracellular compounds due to pulsed electric fieldprocessing显示文摘 | KRISTINA A ULF R ELISABETH B | 2005 | International Journal of Food Microbiology2005，99，： | 1 |
| 16 | Functional Characterization of Novel Mutations Affecting S urvivin ( BIRC 5)‐Mediated Therapy Resistance in Head and Neck Cancer Patients显示文摘 | Shirley K. Knauer Britta Unruhe Sarah Karczewski Rouven Hecht Verena Fetz Carolin Bier Sandra Friedl Barbara Wollenberg Ralph Pries Negusse Habtemichael Ulf‐Rüdiger Heinrich Roland H. Stauber | 2012 | Human Mutation2012，，： | 1 |
| 17 | High-frequency repetitive transcranial magnetic stimulation delays rapid eye movement sleep显示文摘 | Stefan Cohrs Frithjof Tergau Sebastian Riech Sabine Kastner Walter Paulus Ulf Ziemann Eckart Rüther G?ran Hajak | 1998 | NeuroReport1998，，15： | 1 |
| 18 | Breakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanisms显示文摘 | Kristina B. Svendsen Steen Andersen Sigurdur Arnason Staffan Arnér Harald Breivik Tarja Heiskanen Eija Kalso Ulf E. Kongsgaard Per Sjogren Peter Strang Flemming W. Bach Troels S. Jensen | 2004 | European Journal of Pain2004，，2： | 1 |
| 19 | Preparation of catalysts from microemulsions and their application in heterogeneous catalysis显示文摘 | Sara E Ulf N Sergio R | 2004 | Applied Catalysis A:General2004，265，2： | 1 |
| 20 | Increase in Hippocampal Volume After Electroconvulsive Therapy in Patients With Depression A Volu - metric Magnetic Resoance Imaging Study 显示文摘 | Nordanskog Pia Dahlstrand Ulf Larsson Magnus R | 2010 | Journal of ECT2010，26，1： | 1 |
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