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| 1 | Efficacy of intramuscular diclofenac and fluid replacement in prevention of post-ERCP pancreatitis显示文摘AIM:To assess the efficacy of intramuscular diclofenac and fluid replacement for prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis.METHODS: A prospective, placebo-controlled study was conducted in 80 patients who underwent ERCP. Patients were randomized to receive parenteral diclofenac at a loading dose of 75 mg followed by the infusion of 5-10 mL/kg per hour isotonic saline over 4 h after the procedure, or the infusion of 500 mL isotonic saline as placebo. Patients were evaluated clinically, and serum amylase levels were measured 4, 8 and 24 h after the procedure.RESULTS: The two groups were matched for age, sex, underlying disease, ERCP findings, and type of treatment. The overall incidence of pancreatitis was 7.5% in the diclofenac group and 17.5% in the placebo group (12.5% in total). There were no significant differences in the incidence of pancreatitis and other variables between the two groups. In the subgroup analysis, the frequency of pancreatitis in the patients without sphincter of Oddi dysfunction (SOD) was significantly lower in the diclofenac group than in the control group (P=0.047).CONCLUSION: Intramuscular diclofenac and fluid replacement lowered the rate of pancreatitis in patients without SOD. | Altug Senol Ulku Saritas Halil Demirkan | 2009 | World Journal of Gastroenterology2009，15，32： | 20 |
| 2 | Precut sphincterotomy:A reliable salvage for difficult biliary cannulation显示文摘Even experienced endoscopists have 90% success in achieving deep biliary cannulation with standard methods. Biliary cannulation may become difficult in 10%-15% of patients with biliary obstruction and pre- cut (access) sphincterotomy is frequently chosen as a rescue treatment in these cases. Generally, precut sphincterotomy ensures a rate of 90%-100% success- ful deep biliary cannulation. The precut technique has been performed as either a fistulotomy with a needle knife sphincterotome or as a transpapillary septotomy with a standard sphincterotome. Both methods have similar efficacy and complication rates when adminis- tered to the proper patient. Although precut sphincter- otomy ensures over 90% success of biliary cannula- tion, it has been characterized as an independent risk factor for pancreatitis. The complications of the precut technique are not limited to pancreatitis. Two more important ones, bleeding and perforation, are also re- ported in some publications as being observed more commonly than during standard sphincterotomy. It is also reported that precut sphincterotomy increases morbidity when performed in patients without dilata- tion of their biliary tract. Nevertheless, precut sphinc- terotomy is a good alternative as a rescue method in the setting of a failed standard cannulation method. This paper discusses the technical details, timing, ef- ficacy and potential complications of precut sphincter- otomy. | Ulku Saritas Yucel Ustundag Ferda Harmandar | 2013 | World Journal of Gastroenterology2013，19，1： | 13 |
| 3 | Left-sided appendicitis:Review of 95 published cases and a case report显示文摘AIM:To give an overview of the literature on left-sided acute appendicitis (LSAA) associated with situs inversus totalis (SIT) and midgut malrotation (MM).METHODS:We present a new case of LSAA with SIT and a literature review of studies published in the English language on LSAA,accessed via PubMed and Google Scholar databases.RESULTS:Ninety-five published cases of LSAA were evaluated and a 25-year-old female,who presented to our clinic with left lower abdominal pain caused by LSAA,is reported.In the reviewed literature,fiftyseven patients were male and 38 were female with an age range of 8 to 82 years and a median age of 29.1 ± 15.9 years.Sixty-six patients had SIT,23 had MM,three had cecal malrotation,and two had a previously unnoted congenital abnormality.Fifty-nine patients had presentedto the hospital with left lower,14 with right lower and seven with bilateral lower quadrant pain,and seven subjects complained of left upper quadrant pain.The diagnosis was established preoperatively in 49 patients,intraoperatively in 19,and during the postoperative period in five;14 patients were aware of having this anomaly.The data of eight patients were not unavailable.Eleven patients underwent laparoscopic appendectomy,which was combined with cholecystectomy in two cases.Histopathological examination of the appendix specimens revealed adenocarcinoma in only two of 95 patients.CONCLUSION:The diagnosis of left lower quadrant pain is based on well-established clinical symptoms,physical examination and physician's experience. | Sami Akbulut Abdullah Ulku Ayhan Senol Mahmut Tas Yusuf Yagmur | 2010 | World Journal of Gastroenterology2010，16，44： | 9 |
| 4 | Manometric findings in patients with isolated distal gastroesophageal reflux显示文摘AIM:To analyze manometric abnormalities in patients with isolated distal reflux and compare these findings in patients with erosive and non-erosive disease. METHODS:Five hundred and fifty patients who presented to the outpatient clinic of Turkiye Yuksek Ihtisas Hospital with gastroesophageal reflux disease-like symptoms were enrolled.Each individual was evaluated with esophageal manometry,24-h ambulatory pH monitoring,and upper gastrointestinal endoscopy. Manometric findings for the patients with isolated distal reflux were compared to findings in controls who were free of reflux disorders or hypersensitive esopha- gus.Findings for isolated distal reflux patients with and without erosive reflux disease were also compared. RESULTS:Of the 550 subjects enrolled,97(17.6%, mean age 48 years)had isolated distal reflux and 100 had no abnormalities on ambulatory pH monitoring (control group,mean age 45 years).There were no significant differences between the isolated distal reflux group and control group with respect to age,body mass index,and esophageal body contraction amplitude (EBCA).Mean lower esophageal sphincter pressure was significantly higher in the control group(12.7±10.3 mmHg vs 9.6±7.4 mmHg,P=0.01).Fifty-five(56.7%) of the 97 patients with isolated distal reflux had erosive reflux disease.There were no statistical differences be- tween the erosive reflux disease and non-erosive reflux disease subgroups with respect to mean EBCA,lower esophageal sphincter pressure,or DeMeester score.However,13%of patients with gastroesophageal reflux disease had distal wave amplitudes≤30 mmHg, whereas none of the patients with non-erosive reflux disease had distal wave amplitudes in this low category. CONCLUSION:Patients with erosive and non-erosive disease present with similar manometric abnormalities. The only striking difference is the observation of very low EBCA exclusively in patients with erosive disease. | Yasemin Ozin Ulku Dagli Sedef Kuran Burhan Sahin | 2009 | World Journal of Gastroenterology2009，15，43： | 6 |
| 5 | Unusual histopathological findings in appendectomy specimens:A retrospective analysis and literature review显示文摘AIM: To document unusual findings in appendectomy specimens. METHODS: The clinicopathological data of 5262 patients who underwent appendectomies for presumed acute appendicitis from January 2006 to October 2010 were reviewed retrospectively. Appendectomies performed as incidental procedures during some other operation were excluded. We focused on 54 patients who had unusual findings in their appendectomy specimens. We conducted a literature review via the PubMed and Google Scholar databases of English language studies published between 2000 and 2010 on unusual findings in appendectomy specimens. RESULTS: Unusual findings were determined in 54 (1%) cases by histopathology. Thirty were male and 24 were female with ages ranging from 15 to 84 years (median, 32.2 ± 15.1 years). Final pathology revealed 37 cases of enterobiasis, five cases of carcinoids, four mucinous cystadenomas, two eosinophilic infiltrations, two mucoceles, two tuberculosis, one goblet-cell carcinoid, and one neurogenic hyperplasia. While 52 patients underwent a standard appendectomy, two patients who were diagnosed with tuberculous appendicitis underwent a right hemicolectomy. All tumors were located at the distal part of the appendix with a mean diameter of 6.8 mm (range, 4-10 mm). All patients with tumors were alive and disease-free during a mean follow-up of 17.8 mo. A review of 1366 cases reported in the English literature is also discussed. CONCLUSION: Although unusual pathological findings are seldom seen during an appendectomy, all appendectomy specimens should be sent for routine histopathological examination. | Sami Akbulut Mahmut Tas Nilgun Sogutcu Zulfu Arikanoglu Murat Basbug Abdullah Ulku Heybet Semur Yusuf Yagmur | 2011 | World Journal of Gastroenterology2011，17，15： | 4 |
| 6 | The effect on wound healing of pazopanib and bevacizumab compared with corticosteroid in experimental glaucoma filtration surgery显示文摘AIM: To compare the effects of bevacizumab and pazopanib with corticosteroids on wound healing after trabeculectomy. METHODS: In the study, 35 New Zealand white rabbits were randomly divided into five groups. Apart from the first group, limbus-based trabeculectomy was performed for the eyes of rabbits. No postoperative treatment was administered for group Ⅰ. Topically administered saline, prednisolone acetate(1%), bevacizumab 5 mg/mL, pazopanib 5 mg/mL for group Ⅱ, Ⅲ, Ⅳ and Ⅴ respectively were applied for groups 6 h daily for 28 d. On day 28 of the experiment, eyes were enucleated and histologically and immunohistochemically analyzed.RESULTS: The fibroblast counts of groups Ⅳ and Ⅴ were determined to be lower than those of groups Ⅱ and Ⅲ(P<0.05). In the mononuclear cell(MNC) count evaluation, no statistically significant difference was determined between the treatment groups(P>0.05). The immunohistochemical staining intensity of fibroblast growth factor β(FGF-β) and vascular endothelial growth factor(VEGF) was determined to be lower in groups Ⅳ and Ⅴ than in groups Ⅱ and Ⅲ(P<0.05). No statistically significant difference was determined between groups Ⅳ and Ⅴ in respect of fibroblast count, MNC count, FGF-β and VEGF staining intensity(P>0.05). The platelet derived growth factor β(PDGF-β) intensity was lower in group Ⅴ than in groups Ⅱ, Ⅲ and Ⅳ(P<0.05). While the PDGF-β staining intensity was significantly lower in group Ⅳ thanin group Ⅱ, the difference compared with group Ⅲ was not statistically significant(P>0.05). CONCLUSION: Bevacizumab and pazopanib might be good alternatives of corticosteroid treatment on delaying wound healing in glaucoma surgery. | Sabiha Gungor Kobat Fatma Ulku Celiker Adile Ferda Dagli Kader Kasar | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 2 |
| 7 | Value of lead aVR in predicting acute occlusion of proximal left anterior descending coronary artery and in-hospital outcome in ST-elevation myocardial infarction: an electrocardiographic predictor of poor prognosis显示文摘 | Nazif Aygul Kurtulus Ozdemir Mehmet Tokac Meryem Ulku Aygul Mehmet Akif Duzenli Adnan Abaci Ahmet Bacaksiz Hüseyin Yazici Sait Bodur | 2008 | Journal of Electrocardiology2008，，4： | 2 |
| 8 | Outcomes of Covered Kissing Stent Placement Compared with Bare Metal Stent Placement in the Treatment of Atherosclerotic Occlusive Disease at the Aortic Bifurcation显示文摘 | Saher S. Sabri Asim Choudhri Gianluigi Orgera Bulent Arslan Ulku C. Turba Nancy L. Harthun Klaus D. Hagspiel Alan H. Matsumoto John F. Angle | 2010 | Journal of Vascular and Interventional Radiology2010，，7： | 2 |
| 9 | Effects of octreotide acetate and amniotic membrane on wound healing in experimental glaucoma surgery显示文摘 | Tamer Demir Burak Turgut Ulku Celiker Ibrahim Ozercan Fatih Ulas Nuray Akyol | 2003 | Documenta Ophthalmologica2003，，2： | 2 |
| 10 | Re- moval of disinfection by - product precursors by UF and NF membranes in low - SUVA waters 显示文摘 | Nuray Ates Levent Yilmaz Mehmet Kitis Ulku Yetis | 2009 | Journal of Membrane Science2009，328，12： | 1 |
| 11 | Mechanisties of nickel sorption by activated sludge显示文摘 | BETUL A CELAL F G ULKU Y | 2002 | Process Biochemistry2002，37，11： | 1 |
| 12 | Low incidence of colorectal dysplasia and cancer among patients with ulcerative colitis: A Turkish referral centre study显示文摘 | Murat Kekilli Ulku Dagli Ismail Hakki Kalkan Bilge Tunc Selcuk Disibeyaz Aysel Ulker Burhan Sahin | 2010 | Scandinavian Journal of Gastroenterology2010，，4： | 1 |
| 13 | Nickel sorption by acclimatized activated sludge culture显示文摘 | BetulArican Ulku Yetis | 2003 | Water Research2003，37，： | 1 |
| 14 | Low incidence of colorectal dysplasia and cancer among patients with ulcerative colitis: A Turkish referral centre study显示文摘 | Murat Kekilli Ulku Dagli Ismail Hakki Kalkan Bilge Tunc Selcuk Disibeyaz Aysel Ulker Burhan Sahin | 2010 | Scandinavian Journal of Gastroenterology2010，，4： | 1 |
| 15 | Biomechanical evaluation in osteo-porosis: ovariectomized rat mode显示文摘 | Ulku C Selda B Serap Y | 2007 | Clinical Rheumatology2007，2，3： | 1 |
| 16 | The value of collaborative forecasting in supply ehains显示文摘 | Kurtulus M Ulku S Toktay B L | 2012 | Manufacturing & Service Operations Management2012，14，1： | 1 |
| 17 | Matching product architecture and sup- ply chain configuration 显示文摘 | ULKU S SCHM1DT G M | 2010 | Production and Operations Manage- ment2010，20，1： | 1 |
| 18 | Silver,zinc,and copper exchange in a Naclinoptilolite and resulting effect on antibacterial activity 显示文摘 | Ayben Top Semra Ulku | 2004 | Applied Clay Science2004，27，： | 1 |
| 19 | Stock level control policy for a perishable inventory system显示文摘 | Ulku Gurler Emre Berk | 2001 | European Journal of Operational Research2001，，： | 1 |
| 20 | In- trapleural fibrinolytic treatment of trau- matic clotted hemothorax显示文摘 | Inci I Ozcelik C Ulku R | 1998 | Chest1998，114，1： | 1 |
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