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| 1 | Mutagenic and cytotoxic potential of Endosulfan and Lambda-cyhalothrin—In vitro study describing individual and combined effects of pesticides显示文摘Excessive use of pesticides poses increased risks to non target species including humans. In the developing countries, lack of proper awareness about the toxic potential of pesticides makes the farmer more vulnerable to pesticide linked toxicities, which could lead to diverse pathological conditions. The toxic potential of a pesticide could be determined by their ability to induce genetic mutations and cytotoxicity. Hence, determination of genetic mutation and cytotoxicity of each pesticide is unavoidable to legislate health and safety appraisal about pesticides. The objective of current investigation was to determine the genotoxic and cytotoxic potential of Endosulfan(EN) and Lambda-cyhalothrin(LC); individually and in combination. 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide(MTT) assay was utilized to determine cytotoxicity, while two mutant histidine dependent Salmonella strains(TA98, TA100) were used to determine the mutagenicity of EN and LC.Moreover, mutagenicity assay was conducted with and without S9 to evaluate the effects of metabolic activation on mutagenicity. Even though a dose dependent increase in the number of revertant colonies was detected with EN against both bacterial strains, a highly significant(p < 0.05) increase in the mutagenicity was detected in TA98 with S9. In comparison, data obtained from LC revealed less mutagenic potential than EN. Surprisingly,the non-mutagenic individual-concentrations of EN and LC showed dose dependent mutagenicity when combined. Combination of EN and LC synergistically induced mutagenicity both in TA98 and TA100. MTT assay spotlighted comparable dose dependent cytotoxicity effects of both pesticides. Interestingly, the combination of EN and LC produced increased reversion and cytotoxicity at lower doses as compared to each pesticide, concluding that pesticide exposure even at sub-lethal doses can produce cytotoxicity and genetic mutations, which could lead to carcinogenicity. | Umber Saleem Sohail Ejaz Muhammad Ashraf Muhammad Ovais Omer Imran Iltaf Zainab Batool Riffat Fatima Msbah Afzal | 2014 | Journal of Environmental Sciences2014，26，7： | 3 |
| 2 | Mitochondrial transcription factor A and its downstream targets are up-regulat- ed in a rat hepatoma显示文摘 | DONG X GHOSHAL K MAJ'UMBER S | 2002 | J Biol Chem2002，277，43： | 1 |
| 3 | Pets and antimicrobial resistance显示文摘 | Umber Jamie K Bender Jeff | 2009 | B Veterinary Clinics of North America:Small Animal Practice2009，2，： | 1 |
| 4 | SIP-based QoS management architecture for IP multimedia subsystems over IP access networks显示文摘 | Umber iqbal Younas Javed Saad Rehman | | 0，，05： | 1 |
| 5 | Fractures of the thoracolumbar spine in ankylosing spondylitis显示文摘 | Gelman MI Umber JS | 1978 | AIR Am J Roentgenol1978，130，3： | 1 |
| 6 | Emilin1 Links TGF-β Maturation to Blood Pressure Homeostasis显示文摘 | Luca Zacchigna Carmine Vecchione Antonella Notte Michelangelo Cordenonsi Sirio Dupont Silvia Maretto Giuseppe Cifelli Alessandra Ferrari Angelo Maffei Carla Fabbro Paola Braghetta Gennaro Marino Giulio Selvetella Alessandra Aretini Claudio Colonnese Umber | 2006 | Cell2006，，5： | 1 |
| 7 | Fractures of the thoracolumbar spine in ankylosing spondylitis 显示文摘 | Gelman MI Umber JS | 1978 | A JR Am J Roentgenol1978，130，3： | 1 |
| 8 | Intravenous maternal hydration in third trimester oligohydramnios:effect on amniotic fluid volume显示文摘 | Umber A Chohan MA | 2007 | J Coll Physicians Surg Pak2007，17，6： | 1 |
| 9 | Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo : effects on 5-HT cell firing and extracellular 5-HT 显示文摘 | Gartside S E Umbers V Hajos M Sharp T | 1995 | Br J Pharmacol1995，115，6： | 1 |
| 10 | Mutational screening of FOXO3A and FOXO1A in women with premature ovarian fail- ure 显示文摘 | Watkins WJ Umbers AJ Woad KJ | 2006 | Fertil Steril2006，86，5： | 1 |
| 11 | Fractures of the thoracolumbar spine in ankylosing spondylitis显示文摘 | Gelman MI Umber JS | 1978 | Am J Roentgenol1978，130，3： | 1 |
| 12 | Fetal testis dysgenesis and compromised Leydig cell function in Tgibr3 (beta glycan) knockout mice 显示文摘 | Sarraj MA Escalona RM Umbers A | 2010 | Biology of Reproduction2010，82，1： | 1 |
| 13 | Intravenous maternal hydration in third trimester oligohydramnios:effect on amniotic fluid volume显示文摘 | Umber A Chohan MA | 2007 | coll Physicians Surg Pak2007，17，6： | 1 |
| 14 | Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure 显示文摘 | Watkins WJ Umbers AJ Woad K J | 2006 | Fertil Steril2006，86，5： | 1 |
| 15 | Intravenous maternal hydration in third trimester oligohydramnios:effect on amniotic fluid volume显示文摘 | Umber A Chohan MA | 2007 | J Coll Physicians Surg Pak2007，17，6： | 1 |
| 16 | A comparison of pilot-aided channel estima- tion methods for OFDM system 显示文摘 | UMBER M | 2001 | IEEE Trans on Signal Processing2001，，49： | 1 |
| 17 | SIP-based QoS management architecture for IP multimedia subsystems over IP access networks显示文摘 | UMBER L SHALEEZA S and JAVED M Y | 2010 | World Academy of Science Engineering and Technology2010，64，2010： | 1 |
| 18 | Perinatal Outcome in Pregnancies Complicated by Isolated Oligohydramnios at term 显示文摘 | Aneela Umber | 2009 | Annals of King Edward Medical University2009，15，1： | 1 |
| 19 | Intravenous maternal hydration in third trimester oligohydramnios:effect on amniotic fluid volume显示文摘 | Umber A Chohan MA | 2007 | J Coll Physicians Surg Pak2007，17，6： | 1 |
| 20 | Fetal testis dys- genesis and compromised Leydig cell function in Tgfbr3 (beta glycan)knockout mice显示文摘 | Sarraj MA Escalona RM Umbers A | 2010 | Biol Reprod2010，82，1： | 1 |
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