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| 1 | Validated gradient stability indicating HPLC method for determining Diltiazem Hydrochloride and related substances in bulk drug and novel tablet formulation显示文摘A stability-indicating liquid chromatographic method has been developed and validated for the determination of Diltiazem Hydrochloride(DTZ) together with its six related substances(Diltiazem sulphoxide,Imp-A,Imp-B,Imp-D,Imp-E,and Imp-F) in a laboratory mixture as well as in a novel tablet formulation developed in-house.Efficient chromatographic separation was achieved on a Hypersil BDS C_18(150 mm*4.6 mm,5.0 μm) with mobile phase containing 0.2% Triethylamine(TEA) in gradient combination with acetonitrile(ACN) at a flow rate of 1.0 mL/min and the eluent was monitored at 240 nm.In the developed method,the resolution of DTZ from any pair of impurities was found to be greater than 2.0.The test solution and related substances were found to be stable in the diluent for 24 h.The developed method resolved the drug from its known impurities,stated above,and also from additional impurities generated when the formulation was subjected to forced degradation;the mass balance was found close to 99.9%.Regression analyses indicate correlation coefficient value greater than 0.997 for DTZ and its six known impurities.The LOD for DTZ and the known impurities was at a level below 0.02%.The method has shown good,consistent recoveries for DTZ(99.8-101.2%) and also for its six known impurities(97.2-101.3%).The method was found to be accurate,precise,linear,specific,sensitive,rugged,robust,and stability-indicating. | Vivekanand A.Chatpalliwar Pawan K.Porwal Neeraj Upmanyu | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 2 |
| 2 | Blind Authentication: A Secure Crypto-Biometric Verification Protocol 显示文摘 | UPMANYU M NAMBOODIRI A M SRINATHAN K | 2010 | IEEE Transactions on Information Forensics and Security2010，，2： | 1 |
| 3 | Axial-strain-induced torsion in single-walled carbon nantoubes显示文摘 | LIANG H Y UPMANYU M | 2006 | Physical Review Letters2006，96，： | 1 |
| 4 | Curvature driven grain boundary migration in aluminum: molecular dynamics simulations显示文摘 | H. Zhang M. Upmanyu D.J. Srolovitz | 2004 | Acta Materialia2004，，： | 1 |
| 5 | Sire ulations of boundary migration during recrystallization using molecular dynamics 显示文摘 | Godiksen R B Trautt Z T Upmanyu M eta/ | 2007 | Acta Materialia2007，55，： | 1 |
| 6 | Misorientation dependence of intrinsic grain boundary mobility: simulation and experiment显示文摘 | M. Upmanyu D.J. Srolovitz L.S. Shvindlerman G. Gottstein | 1999 | Acta Materialia1999，，： | 1 |
| 7 | Blind authentication: a secure crypto-biometricverification protocol 显示文摘 | UPMANYU M NAMBOODIRI A M SRINATHAN K etal | 2010 | Information Forensics andSecurity IEEE Transactions on2010，5，2： | 1 |
| 8 | Atomistic Simulation of Curvature Driven Grain Boundary Migration显示文摘 | M. Upmanyu R.W. Smith D.J. Srolovitz | 1998 | Interface Science1998，，： | 1 |
| 9 | Axial-strain-induced torsion in single-walled carbon nantoubes显示文摘 | Liang H Y Upmanyu M | 2006 | Physical Review Letters2006，96，16： | 1 |
| 10 | A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting显示文摘 | Karason A Gudjonsson JE Upmanyu R | 2003 | Am J Hum Genet2003，72，1： | 1 |
| 11 | Boundary Mobility and Energy Anisotropy Effects on Microstructural Evolution During Grain Growth显示文摘 | M. Upmanyu G.N. Hassold A. Kazaryan E.A. Holm Y. Wang B. Patton D.J. Srolovitz | 2002 | Interface Science (-)2002，，2： | 1 |
| 12 | IL-6 pathway- driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis 显示文摘 | Wang J Platt A Upmanyu R | 2013 | BMJ Open2013，193，03： | 1 |
| 13 | Fluctuations in molecular dynamics simulations 显示文摘 | HOYT J J TRAUTr Z T UPMANYU M | 2010 | Mathematics and Computers in Simulation2010，80，7： | 1 |
| 14 | Grain boundary stiffness based on a dislocation model 显示文摘 | Upmanyu M | 2007 | Scripta Materialia2007，56，6： | 1 |
| 15 | Assessment by HPLC of the degradation behavior of acitretin under hydrolytic,oxidative,photolytic and thermal stress conditions显示文摘Acitretin is a photosensitive oral retinoid with very limited data available on its degradation.The official HPLC method for acitretin determination was insufficient to resolve the degradation products generated during stability studies.Therefore,an isocratic RP-HPLC-UV method was developed for the determination of acitretin in the presence of its related impurities and degradation products.Efficient chromatographic separation was achieved on a Thermo beta-basic column C18(100 mm4.6 mm,5μm)with mobile phase containing 0.3%(v/v)glacial acetic acid with acetonitrile(ACN)and isopropyl alcohol(IPA)in an isocratic ratio of 70:30 at a flow rate of 1.0 mL/min with the eluent monitored at 360 nm.The method was validated for specificity,linearity,precision,accuracy and robustness.The calibration plot was linear over the concentration range of 50-150μg/mL with a correlation coefficient(r2)of 0.999.The proposed method was used to investigate the degradation kinetics of acitretin under the different degradative conditions.The degradation rate constant(K),half-life(t1/2),and t90 were calculated.Degradation of acitretin followed pseudo-first-order kinetics.The drug was found to be less stable under acidic and photolytic degradation conditions:the photolytic degradation constants for acitretin in sunlight and UV light were 0.002698%and 0.0008402%min1,respectively.The LOD for acitretin and the known impurities were at a level below 0.02%.The method shows consistent recoveries for ACTR(99.8%-101.2%)and also for its known impurities(97.2-101.3%).The method was found to be accurate,precise,linear,specific,sensitive,rugged,robust,and useful for characterizing the stability of this chemical. | Pawan K.Porwal Neeraj Upmanyu | 2014 | Acta Pharmaceutica Sinica B2014，4，6： | 1 |
| 16 | Vacancy Generation During Grain Boundary Migration显示文摘 | M. Upmanyu D.J. Srolovitz L.S. Shvindlerman G. Gottstein | 1998 | Interface Science1998，，4： | 1 |
| 17 | IL-6 pathway-driven investigation of response to IL-6 receptor inhibitionin rheumatoid arthritis 显示文摘 | WANG J PLATT A UPMANYU R | 2013 | BMJ Open2013，3，00： | 1 |
| 18 | A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting显示文摘 | Karason A Gudjonsson J E Upmanyu R | 2003 | Am J Hum Genet2003，72，1： | 1 |
| 19 | Central nervous system activity of Illicium verum fruit extracts显示文摘Objective:To research the acute toxicity of Illicium verum(I.verum)fruit extracts and its action on central nervous system.Methods:The TLC and HPTLC techniques were used as fingerprints to determine the chemical components present in I.verum.Male albino rats and mice were utilized for study.The powdered material was successively extracted with n-hexane,ethyl acetate and methanol using a Soxhlet extractor.Acute toxicity studies were performed as per OECD guidelines.The CNS activity was evaluated on parameters of general behavior,sleeping pattern,locomotor activity,anxicty and myocoordination activity.The animals were trained for seven days prior to experiments and the divided into five groups with six animals in each.The drug was administered by intraperitoneal route according to body weight.The dosing was done as prescribed in each protocol.Results:Toxicity studies reported 2 000 mg/kg as toxicological dose and 1/10 of the same dose was taken as therapeutic dose Intraperitoneal injection of all extracts at dose of 200 mg prolonged phenobarbitone induced sleeping time,produced alteration in general behavior pattern,reduced locomotor activity and produced anxiolytic effects but the extracts do not significantly alter muscles coordination activity.The three extracts of I.verum at the dose of 200 mg,methanol extract was found to produce more prominent effects,then hexane and ethylacetate extracts.Conclusions:The observation suggested that the extracts of I. verum possess potent CNS depressant action and anxiolytic effect without interfering with motor coordination. | Divya Chouksey Neeraj Upmanyu RS Pawar | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，11： | 1 |
| 20 | Curvature driven grain boundary migration in aluminum: Molecular dynamics simulations 显示文摘 | ZHANG H UPMANYU N SROLOVITZ D J | 2005 | Acta Mater2005，53，： | 1 |
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