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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Sperling任务中刺激呈现方式对注意分配的影响显示文摘以全部报告法和部分报告法为任务,在Kosslyn瞬时记忆模型框架下,探讨当刺激呈现和报告的方式按列进行时,被试注意窗的放置策略及其对瞬时记忆的影响。结果发现,部分报告优势在这种条件下也是存在的;因为长期的学习而导致的阅读习惯对注意窗放置策略的影响是稳定的;同时发现这种策略使得被试在按列进行的报告方式时,全部报告法和部分报告法的成绩都低于按行报告方式。文章还对上述实验发现作出了进一步的讨论。 | 陈国鹏 王晓丽 方芸秋 Uta Lass Song Yan Dietrich Becker Gerd Lüer | 2004 | 心理科学2004，27，3： | 2 |
| 3 | Simultaneous occurrence of a hepatocellular carcinoma and a hepatic non-Hodgkin's lymphoma infi ltration显示文摘To investigate the simultaneous occurrence of hepatocellular carcinoma and non-Hodgkin's lymphoma, we report the case of a 70 year old patient with a primary diagnosis of non-Hodgkin's lymphoma in 2002. In a routine follow up investigation of his chronic lymphocytic leukemia a newly detected mass in the Couinaud's segments 2 and 3 was found. No hepatitis C virus or hepatitis B virus infection or cirrhosis was evident. After laparoscopic segmentectomy the histological examination revealed a hepatocellular carcinoma. While the relation between liver parenchyma damages and hepatocellular carcinoma or non-Hodgkin's lymphoma is well known, only a few publications have focused on the coexistence of hepatocellular carcinoma and non-Hodgkin's lymphoma. With this case we demonstrate the coexistence of these diseases without having a pre- damaged liver parenchyma. | Sabine Heidecke Dirk L Stippel Arnulf H Hoelscher Inga Wedemeyer Hans-Peter Dienes Uta Drebber | 2010 | World Journal of Hepatology2010，2，6： | 2 |
| 4 | Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial显示文摘 | Jayant S Vaidya David J Joseph Jeffrey S Tobias Max Bulsara Frederik Wenz Christobel Saunders Michael Alvarado Henrik L Flyger Samuele Massarut Wolfgang Eiermann Mohammed Keshtgar John Dewar Uta Kraus-Tiefenbacher Marc Sütterlin Laura Esserman Helle MR Ho | 2010 | The Lancet2010，，9735： | 1 |
| 5 | Prospective muhicenter study with a new implant for thoracolumbar vertebral body replacement 显示文摘 | Uta L Christian K Leonard B | 2003 | Arch Orthop Trauma Surg2003，123，： | 1 |
| 6 | Assessment of hepatic ischemica-reperfusion injury by simultaneous measurement of tissue P02,PC02,and PH显示文摘 | Drik Uhlmann Uta Pietsch Stefan L | 2004 | Micro Res2004，67，1： | 1 |
| 7 | Determination of microvessel density by quantitative real-time PCR in esophageal cancer:correlation with histologic methods,angiogenic growth factor expression,and lymph node metastasis显示文摘 | Sonja L Henning C Uta R | 2007 | Clin Cancer Res2007，13，1： | 1 |
| 8 | Cashflow-at-risk and financial policy for electricity companies in the new world order显示文摘 | LaGATI'UTA D A STEIN J C TENNICAN M L | 2000 | The Electricity Journal2000，13，10： | 1 |
| 9 | Factors influencing the sinking of POC and the efficiency of the biological carbon pump显示文摘 | Christina L De La Rocha Uta Passow | 2007 | Deep-Sea Research Ⅱ:Topical Studies in Oceanography2007，54，557： | 1 |
| 10 | Assessment of hepatic ischemia-reperfusion injury by simultaneous measurement of tissue PO2,PC02 and PH显示文摘 | Dirk Uhlmann Uta Pietsch Stefan L | 2004 | Micro Res2004，67，1： | 1 |
| 11 | Cross-Sectional Multi-Center Study of Patients with Urea Cycle Disorders in the United States显示文摘 | Mendel T Brendan L Uta LK | 2008 | Mol Genet Metab2008，94，4： | 1 |
| 12 | Homologous genes for enolase,phosphogluconate dehydrogenase,phosphoglucemutase,and adenylate kinase are syntenic on mouse chromesome 4 and human chromosome 1p显示文摘 | PETER A L UTA F JOHN D M | 1978 | Proc Nati Acad Sci USA1978，75，5： | 1 |
| 13 | Gene Expression Patterns Vary in Clonal cell Cultures from Rett Syndrome Females with Eight Different MECP2 Mutations显示文摘 | JEFF T PRIYANKA A LAURA L UTA F | 2002 | BMC Med Genet2002，，3： | 1 |
| 14 | Standardized assessment of strategy use and working memory in early mental arithmetic performance 显示文摘 | Sarah S W Meghan L M Uta M | 2008 | Developmental Neuropsychology2008，33，3： | 1 |
| 15 | Determination of microvessel density by quantitative real-time PCR in esophageal cancer: Correlation with histologic methods, angiogenic growth factor expression, and lymph node mctastasis显示文摘 | Sonja L Henning C Uta R | 2007 | Clinical Cancer Research2007，13，： | 1 |
| 16 | Assessment of hepatic ischemia-reperfusion injury by simultaneous measurement of tissue PO2,PCO2 and PH显示文摘 | Dirk Uhlmann Uta Pietsch Stefan L | 2004 | Micro Res2004，67，1： | 1 |
| 17 | Homologous genes for enolase,phosphogluconate dehydrogenase,phosphoglucomutase,and adenylate kinase are syntenic on mouse chromosome 4 and human chromosome l显示文摘 | Peter A L Uta F John D M | 1978 | Proceedings of the National Academy of Sciences1978，75，5： | 1 |
| 18 | Community structure of epilithic lichens on the cliffs of the Niagara Escarpment, Ontario, Canada显示文摘 | Uta M Brnce D R Douglas W L | 2000 | Plant E- cology2000，148，： | 1 |
| 19 | Application of microdialysis forthe determination of muscle and subcutaneous tissue concentra-tions after oral and topical ibuprofen administration显示文摘 | Irmgard T Uta M S Jorn L | 1999 | ClinPharmacol Ther1999，65，4： | 1 |
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