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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy显示文摘 | Uta Drebber Max Lay Inga Wedemeyer Daniel Vallb?hmer Elfriede Bollschweiler Jan Brabender Stefan M?nig Arnulf H?lscher Hans Dienes Margarete Odenthal | 2011 | International Journal of Oncology2011，，： | 2 |
| 3 | A new apparatus for determining SH-CCT diagrams for welding and its application to high strenght steels显示文摘 | Inagaki M Uta M Wada T | 1964 | Transactions of National Research Institute for metals1964，，16： | 1 |
| 4 | Pentylenetetrazole (PTZ) - induced c-fos expression in the hippocampus of kindled rats in suppressed by concomitant treatment with Naloxone 显示文摘 | Martina EV Uta R Peter M | 1998 | Brain Res1998，792，3： | 1 |
| 5 | Landscape Metrics for Assessment of Landscape Destruction and Rehabilitation显示文摘 | FELIX HERZOG ANGELA LAUSCH ECKHARD MüLLER HANS-HERMANN THULKE UTA STEINHARDT STEFFEN LEHMANN | | Environmental Management0，，： | 1 |
| 6 | Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome显示文摘 | Joachim Spranger Matthias Mhlig Uta Wegewitz | 2004 | Clinical Endocrinology2004，61，6： | 1 |
| 7 | Pentyenetetrazole(PTZ)-induced c-fos expression in the hippocampus of kindled rats in suppressed by concomitant treatment with naloxone显示文摘 | Martina EV Uta R Peter M | 1998 | Brain Res1998，792，： | 1 |
| 8 | Pentylenetetrazole (PTZ) -- induced c--los expression in the hippocampus of kindled rats in sup- pressed by concomitant treatment with Naloxone显示文摘 | Martina EV Uta R Peter M | 1998 | Brain Res1998，792，3： | 1 |
| 9 | Neoadjuvant chemoradiotherapy for esophageal cancer:Impact on extracapsular lymph node involvement显示文摘AIM:To assess the effects of neoadjuvant chemoradiotherapy(CRT) on the presence of extracapsular lymph node involvement(LNI) and its prognostic value in patients with resected esophageal cancer.METHODS:Two hundred and ninety-eight patients with advanced esophageal cancer underwent esophagectomy between 1997 and 2006.One hundred and ninety patients(63.8%) were treated with neoadjuvant CRT prior to resection.A total of 986 metastatic LNs were examined.Survival of the patients was analyzed according to intra-and extra-capsular LNI.RESULTS:Five-year survival rate was 22.5% for the entire patient population.Patients with extracapsular LNI had a 5-year survival rate of 16.7%,which was comparable to the 15.8% in patients with infiltrated nodes of the celiac trunk(pM1lymph).In contrast to patients treated with surgery alone,neoadjuvant therapy resulted in signif icantly(P = 0.001) more patients with pN0/M0(51.6% vs 25.0%).In 17.6% of the patients with surgery alone vs 16.8% with neoadjuvant CRT,extracapsular LNI was detected.Neoadjuvant therapy does not reduce the occurrence of extracapsular LNI.CONCLUSION:Extracapsular LNI is an independent negative prognostic factor not influenced by neoadjuvant CRT.In a revised staging system for esophageal cancer,extracapsular LNI should be considered. | Ralf Metzger Elfriede Bollschweiler Uta Drebber Stefan P Mnig Wolfgang Schrder Hakan Alakus Martin Kocher Stephan E Baldus Arnulf H Hlscher | 2010 | World Journal of Gastroenterology2010，16，16： | 1 |
| 10 | The overexpression of c-met as a prognostic indicator for gastric carcinomacompared to p53 and p21 nuclear accumulation显示文摘 | Uta Drebber Stephan Baldus Britt Nolden Guido Grass Elfriede Bollschweiler Hans Dienes Arnulf H?lscher Stefan M?nig | 2008 | Oncology Reports2008，，6： | 1 |
| 11 | Early gastric cancer:lymph node metastasis starts with deep mucosal infiltration显示文摘 | Amulf H Uta D Stefan M | 2009 | Ann Surg2009，250，5： | 1 |
| 12 | Cashflow-at-risk and financial policy for electricity companies in the new world order显示文摘 | LaGATI'UTA D A STEIN J C TENNICAN M L | 2000 | The Electricity Journal2000，13，10： | 1 |
| 13 | Landscape Metrics for Assessment of Landscape Destruction and Rehabilitation显示文摘 | FELIX HERZOG ANGELA LAUSCH ECKHARD MüLLER HANS-HERMANN THULKE UTA STEINHARDT STEFFEN LEHMANN | 2001 | Environmental Management2001，，1： | 1 |
| 14 | Mitochondrial dysfunction in sporadic and genetic Alzheimer’s disease显示文摘 | Susanne Hauptmann Uta Keil Isabel Scherping Astrid Bonert Anne Eckert Walter E. Müller | 2006 | Experimental Gerontology2006，，： | 1 |
| 15 | Pentylenetetrazole (PTZ) - induced c - fos expression in the hippocampus of kindled rats in suppressed by coneomitant treatment with Naloxone 显示文摘 | Martina EV Uta R Peter M | 1998 | Brain Res1998，792，3： | 1 |
| 16 | Early Gastric Cancer: Lymph Node Metastasis Starts With Deep Mucosal Infiltration显示文摘 | Arnulf H. H?lscher Uta Drebber Stefan P. M?nig Christian Schulte Daniel Vallb?hmer Elfriede Bollschweiler | 2009 | Annals of Surgery2009，，5： | 1 |
| 17 | Early gastric cancer:lymph node metastasis starts with deep mucosal infiltration显示文摘 | Arnulf H Uta D Stefan M | 2009 | Ann Surg2009，250，5： | 1 |
| 18 | Clinical evaluation of roxithromycin:a double-blind, placebo-controlled and crossover trial in patients with acne vulgaris显示文摘 | Ferahbas A Utas S Aykol D Borlu M Uksal U | 2004 | J Dermatol2004，31，： | 1 |
| 19 | Homologous genes for enolase,phosphogluconate dehydrogenase,phosphoglucemutase,and adenylate kinase are syntenic on mouse chromesome 4 and human chromosome 1p显示文摘 | PETER A L UTA F JOHN D M | 1978 | Proc Nati Acad Sci USA1978，75，5： | 1 |
| 20 | Pentyenetetrazole(PTZ)-induced c-fos expression in the hippocampus of kindled rats in suppressed by concomitant treatment with Naloxone显示文摘 | Martina EV Uta R Peter M | 1998 | Brain Res1998，792，： | 1 |
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