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| 1 | Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma显示文摘AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus(HCV)related hepatocellular carcinoma(HCC).METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective study.All patients had chronic liver disease(CLD) due to infection with HCV.Thirty patients with HCV-related HCC,34 with HCV-related CLD without HCC(non-HCC),and 20 healthy volunteers(HVs) were enrolled.Possible associations between serum manganese superoxide dismutase(MnSOD) and thioredoxin(TRX) levels and clinical parameters or patient prognosis were analyzed over a mean follow-up period of 31.7 mo.RESULTS:The serum MnSOD levels were significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.03) or HVs(P < 0.001).Similarly,serum TRX levels were also significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.04) or HVs(P < 0.01).However,serum levels of MnSOD and TRX were not correlated in patients with HCC.Among patients with HCC,the overall survival rate(OSR) was lower in patients with MnSOD levels ≥ 110 ng/mL than in patients with levels < 110 ng/mL(P = 0.01),and the OSR tended to be lower in patients with TRX levels < 80 ng/mL(P = 0.05).In addition,patient prognosis with HCC was poorest with serum MnSOD levels ≥ 110 ng/mL and serum TRX levels < 80 ng/mL.Furthermore,a multivariate analysis using a Cox proportional hazard model and serum levels of five factors(MnSOD,prothrombin time,serum albumin,serum α-fetoprotein(AFP),and serum des-γ-carboxy prothrombin) revealed that MnSOD levels ≥ 110 ng/mL(risk ratio:4.12,95% confidential interval:1.22-13.88,P = 0.02) and AFP levels ≥ 40 ng/mL(risk ratio:6.75;95% confidential interval:1.70-26.85,P < 0.01) were independent risk factors associated with a poor patient prognosis.CONCLUSION:Serum MnSOD and TRX levels are potential clinical biomarkers that predict patient prognosis in HCV-related HCC. | Tsutomu Tamai Hirofumi Uto Yoichiro Takami Kouhei Oda Akiko Saishoji Masashi Hashiguchi Kotaro Kumagai Takeshi Kure Seiichi Mawatari Akihiro Moriuchi Makoto Oketani Akio Ido Hirohito Tsubouchi | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 2 | Acta Biomat:开发出可促进机体神经组织再生的新型网格纤维结构显示文摘近日。一项刊登在国际杂志Acta Biomaterialia上的研究报告中。来自日本大阪大学的研究人员通过研究开发出了一种网格结构。其能够被缠绕在损伤的周围神经组织上来帮助促进损伤神经的再生并且恢复其功能。 | Koji Suzuki Hiroyuki Tanaka Mitsuhiro Ebara Koichiro Uto Hozo Matsuoka Shunsuke Nishimoto Kiyoshi Okada Tsuyoshi Murase Hideki Yoshikawa | 2017 | 现代生物医学进展2017，17，18： | 4 |
| 3 | Improvement of glucose tolerance by nateglinide occurs through enhancement of early phase insulin secretion显示文摘 | Uto Y Teno S Iwamoto Y | 2002 | Metabolism2002，51，： | 2 |
| 4 | Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma显示文摘 | Kohichiroh Yasui Etsuko Hashimoto Yasuji Komorizono Kazuhiko Koike Shigeki Arii Yasuharu Imai Toshihide Shima Yoshihiro Kanbara Toshiji Saibara Takahiro Mori Sumio Kawata Hirofumi Uto Shiro Takami Yoshio Sumida Toshinari Takamura Miwa Kawanaka Takeshi Oka | 2011 | Clinical Gastroenterology and Hepatology2011，，5： | 2 |
| 5 | An angiotensin-converting enzyme inhibitor, not an angiotensin II type- 1 receptor blocker, prevents beta- aminopropionitrile monofumarate-induced aortic dissection in rats显示文摘 | Nagashima H Uto K Sakomura Y | 2002 | J Vasc Surg2002，36，4： | 1 |
| 6 | Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked maerophages:Structure-activity relationship and molecular mechanisms involved显示文摘 | Hou DX Yanagita T Uto T | | 0，，03： | 1 |
| 7 | Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes显示文摘 | Uto Y Nagashima H | 2000 | Diabetes Care2000，923，9： | 1 |
| 8 | Association of postprandial hyper- triglyceridemia and carotid intima - media thickenss in patients with type2 diabetes 显示文摘 | Teno S Iwamoto Y Uto Y | 2000 | Diabetes Care2000，23，： | 1 |
| 9 | Gene therapy targeting for hepatocellular carcinoma: Selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human alpha-fetoprotein promoter 显示文摘 | Ido A Uto H Moriuchi A | 2001 | Cancer Res2001，61，： | 1 |
| 10 | Two delayed cases of traumatic diaphragmatic hernia显示文摘 | Ischibe R Ogata S Uto M | 2004 | Kyobu Geka2004，57，3： | 1 |
| 11 | Clinical fea- tures of hepatitis C virus carriers with persistently normal alanine aminotransferase levels 显示文摘 | Hirofumi Uto Seiich Mawatari Kotaro Kumagai | 2012 | Hepat Mon2012，12，2： | 1 |
| 12 | Uptake of biodegradable po- ly( gamma- glutamic acid) nanoparticles and antigen presentation by dendritic ceils in vivo显示文摘 | UTO T TOYAMA M NISHI Y | 2013 | Results Immunol2013，3，： | 1 |
| 13 | Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes显示文摘 | Teno S Uto Y Nagashima H | 2000 | Diabetes Care2000，23，9： | 1 |
| 14 | Protein direct delivery to dendritic cells using nanoparticles based on amphiphilic poly (amino acid) derivatives显示文摘 | Akagi T Wang X Uto T Baba M Akashi M | | 0，，23： | 1 |
| 15 | Nitric oxide induces apopto-sis via Ca2+-dependent processes in the pancreatic beta-cell line MIN6 显示文摘 | Nakata M Uto N Maruyama I | 1999 | Cell Struct Funct1999，24，6： | 1 |
| 16 | 17-Hydroxy-jolkinolide B,a diterpenoid from Euphorbia fischeriana,inhibits inflammatory mediators but activates heme oxygenase-1 expression in lipopolysaccharide-stimulated murine macrophages显示文摘 | Uto T Qin GW Morinaga O | 2012 | Int Immunopharmacol2012，12，1： | 1 |
| 17 | Synthesis and biological activity of 1-methyl-tryptophan- tirapazamine hybrids as hypoxia-targeting indoleaine 2,3-dioxygenase inhibitors 显示文摘 | NAKASHIMA H UTO Y NAKATA E | 2008 | Bioorg Med Chem2008，16，18： | 1 |
| 18 | KL-6 as a potential new marker for amiodarone-induced puhnonary toxicity 显示文摘 | Endoh Y Hanai R Uto K | 2000 | Am J Cardiol2000，86，2： | 1 |
| 19 | MnO,-CeO2 binary oxides for catalytic NO, sorption at low temperatures, sorptive remov- al of NOx显示文摘 | Machida M Uto M Kurogi D | 2000 | Chem Mater2000，12，10： | 1 |
| 20 | Blue gold in Japan-policy idea on creating a new water trading system coping with expected water issues in Japan based on comparison studies显示文摘 | Tetsuji UEMURA Massaki UTO | | 0，，160： | 1 |
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