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| 1 | Albumin liver dialysis as pregnancy-saving procedure in cholestatic liver disease and intractable pruritus显示文摘Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare cholestatic liver disease. Such liver disease can get worse by female hormone disorder. Albumin dialysis or Molecular Adsorbent Recirculating System (MARS) has been reported to reverse severe cholestasis-linked pruritus. Here, we report the first use of MARS during a spontaneous pregnancy and its successful outcome in a patient with PFIC3 and intractable pruritus. Albumin dialysis could be considered as a pregnancy-saving procedure in pregnant women with severe cholestasis and refractory pruritus. | Maud Lemoine Aurélie Revaux Claire Francoz Guillaume Ducarme Sabine Brechignac Emmanuel Jacquemin Michèle Uzan Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，42： | 14 |
| 2 | 雷公藤红素阻断全反式维甲酸导致的白血病细胞与内皮细胞黏附显示文摘目的:全反式维甲酸(all-trans retinoic acid,ATRA)治疗急性早幼粒细胞白血病,引起白血病细胞与内皮细胞之间黏附增加,是发生维甲酸综合征的重要原因。本文观察雷公藤红素对这种黏附增加的影响。方法:用流式细胞术检测雷公藤红素对急性早幼粒细胞白血病细胞系NB4和人脐静脉内皮细胞(humanumbilical vascular endothelial cell,HUVEC)在ATRA刺激下表达黏附分子的影响。用细胞黏附功能实验,检测雷公藤红素对ATRA导致的上述两种细胞之间黏附增加的影响。结果:ATRA能引起NB4细胞表面细胞间黏附分子-1(intercellular adhesion molecule-1,ICAM-1)表达增加,但可被雷公藤红素明显抑制(P<0.01)。NB4细胞上清液能刺激HUVEC表达ICAM-1(P<0.05);而被ATRA处理过的NB4细胞上清液能明显刺激HUVEC表达选择素E(E-selectin)、血管细胞黏附分子-1(vascular cell adhesion molecule-1,VCAM-1)和ICAM-1等黏附分子(P<0.01),雷公藤红素对其抑制率分别达25.3%、42.4%和61.0%。ATRA导致上述两种细胞之间黏附增加,雷公藤红素对其完全抑制。结论:雷公藤红素能抑制ATRA导致的白血病细胞与内皮细胞黏附,有可能用于维甲酸综合征的治疗。 | 徐莉敏 张登海 杨春欣 刘旭辉 Geroges UZAN 秦万章 | 2007 | 中西医结合学报2007，5，3： | 11 |
| 3 | Celastrol targets IRAKs to block Toll-like receptor 4-mediated nuclear factor-κB activation显示文摘OBJECTIVE: Celastrol has been established as a nuclear factor-κB(NF-κB) activation inhibitor; however, the exact mechanism behind this action is still unknown. Using text-mining technology, the authors predicted that int erleukin-1 receptor-associated kinases(IRA Ks) are potential celastrol targets, and hypothesized that targeting IRAKs might be one way that celastrol inhibits NF-κB. This is because IRAKs are key molecules for some crucial pathways to activate NF-κB(e.g., the inter leukin-1 receptor(IL-1R)/Toll- like receptor(TLR) superfamily).METHODS: The human hepatocellular cell line(Hep G2) treated with palmitic acid(PA) was used as a model for stimulating TLR4/NF-κB activation, in order to observe the potential effects of celastrol in IRAK regulation and NF-κB inhibition. The transfection of small interfering RNA was used for down-regulating TLR4, IRAK1 and IRAK4, and the Western blot method was used to detect changes in the protein expressions.RESULTS: The results showed that celastrol could effectively inhibit PA-caused TLR4-dependent NF-κB activation in the Hep G 2 cells; PA also activated IRAKs, which were inhibited by celastrol. Knocking down IRAKs abolished PA-caused NF-κB activation.CONCLUSION: The results for the first time show that targeting IRAKs is one way in which celastrol inhibits NF-κB activation. | Yu-fan Shen Xue Zhang Ying Wang Fan-fan Cao Georges Uzan Bin Peng Deng-hai Zhang | 2016 | Journal of Integrative Medicine2016，14，3： | 8 |
| 4 | 雷公藤红素对ATRA诱导白血病细胞分化成熟的影响显示文摘目的观察雷公藤红素对ATRA诱导白血病细胞分化成熟的影响。方法用细胞形态学、生化指标、分子标志等指标,观察雷公藤红素和/或ATRA不同处理组NB4分化情况。结果与对照组相比,ATRA诱导后,NB4细胞呈现中性粒细胞分叶核形态;NBT还原能力明显增加;分化抗原CD13和CD33表达下降,而CD11b和CD15表达增加。雷公藤红素与ATRA联合应用,结果与ATRA处理组相似。结论雷公藤红素不影响ATRA诱导NB4细胞分化成熟作用,提示雷公藤红素作为分化综合征的治疗和预防药物值得进一步研究。 | 徐莉敏 张登海 杨春欣 彭彬 曹帆帆 Geroges UZAN | 2010 | 同济大学学报(医学版)2010，31，3： | 3 |
| 5 | Steroid profiling in preeclamptic women: evidence for aromatase deficiency显示文摘 | Alexandre Hertig Philippe Liere Nathalie Chabbert-Buffet Julie Fort Antoine Pianos Bernard Eychenne Annie Cambourg Michael Schumacher Nadia Berkane Guillaume Lefevre Serge Uzan Eric Rondeau Patrick Rozenberg Marie-Edith Rafestin-Oblin | 2010 | American Journal of Obstetrics and Gynecology2010，，5： | 2 |
| 6 | Septate uterus and reproduction disorders: current results of hysteroscopic septoplasty显示文摘 | Zabak K Bettifla JL Uzan S | 2001 | Gynecol Obstet Fertil2001，29，11： | 1 |
| 7 | Eutopic endometrium and peri- toneal, ovarian and bowel endometriotic tissues express a different profile of matrix metalloproteinases - 2, - 3 and - ll,and of tissue in- hibitor metalloproteinases - 1 and - 2 显示文摘 | Uzan C Cortez A Dufoumet C | 2004 | Virchows Arch2004，45，6： | 1 |
| 8 | Management and prognosis of clear cell borderline ovarian tumor显示文摘 | Uzan C Dufeu-Lefebvre M Fauvet R | 2012 | Int J Gy- necol Cancer2012，22，6： | 1 |
| 9 | The value of repeated determinations of natriuretic peptide for diagnosis unstable angina显示文摘 | Leogoy G Uzan L Bugugnani F | 2003 | Arch Mal Coeur Vaiss2003，96，4： | 1 |
| 10 | Specific activation of the non-classical class Ⅰ histocompatibility HLA-G antigen and expression of the ILT2 inhibitory receptor in human breast cancer显示文摘 | Lefebvre S Antoine M Uzan S | 2002 | J Pathol2002，196，： | 1 |
| 11 | The value of repeated determinations of brain natfiuretic peptide for the diagnosis of unstable angina 显示文摘 | Leroy G Uzan L Bugugnani MJ | 2003 | Arch Mal Cocur Vaiss2003，96，4： | 1 |
| 12 | Permanent deformation in flexible pavements 显示文摘 | Uzan J | 2004 | Journal of Transportation Engineering2004，130，1： | 1 |
| 13 | Gynaecological cancers in pregnancy显示文摘 | Morice P Uzan C Gouy S | | 0，，： | 1 |
| 14 | Neonatal growth and regeneration of beta-cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats显示文摘 | Figeac F Uzan B Faro M | 2010 | Am J Physiol Endocrinol Metab2010，298，1： | 1 |
| 15 | GP Ⅱ b and GP Ⅲ a amino acid sequences deduced from human megakaryocyte cDNAs显示文摘 | Frachet P Uzan G Thevenon D | 1990 | Mol Biol Rep1990，14，1： | 1 |
| 16 | Eutopic endometrium and peritoneal,ovarian and bowel endometriotic tissues express a different profile of matrix metalloproteinases-2,-3,and-11,and of tissue inhibitor metalloproteinases-1,and -2显示文摘 | UZAN C CORTEZ A DUFOURNET C | 2004 | Virchows Arch2004，445，6： | 1 |
| 17 | Speckle Denoising in Digital Holography by Nonlocal Means Filtering 显示文摘 | UZAN A R1VENSON Y STERN A | 2013 | Applied Optics2013，52，1： | 1 |
| 18 | Pregnancy-associated breas cancer is as chemosensitive as non-pregnancy-associated breast cancer in the neoadjuvant setting 显示文摘 | Rouzier R Werkoff G Uzan C | 2011 | Ann Oneol2011，22，7： | 1 |
| 19 | Neuroglobin and other hexacoordinated hemoglobins show a weak temperature dependence of oxygen binding 显示文摘 | Uzan J Dewilde S Burmester T | 2004 | Biophys2004，87，2： | 1 |
| 20 | Value of intraoperative imprint cytology of sentinel nodes in patents with cervical cancer 显示文摘 | Barranger E Cortez A Uzan S | 2004 | Gynecol Oncol2004，94，1： | 1 |
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