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| 1 | Oocyte Cryopreservation in Human Assited Reproduction显示文摘Embryo cryopreservation(CP) has became a very important part of the clinical use of in vitro fertilization. Oocyte CP offers more advantages compared with embryo freezing with regard to less ethical, legal and moral problems. However, the efficiency of this procedure is still low, which prevents its clinical application in wide range. The aim of our paper is to review the basic principles, technical and safety aspects and current status of oocyte cryopreservation in human assisted reproduction. | J Konc S Cseh E Varga R Kriston K Kanyó | 2006 | Journal of Reproduction and Contraception2006，17，2： | 7 |
| 2 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 3 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 4 | Antioxidant and free radical scavenging activities of 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia 显示文摘 | PF REZ G R M VARGAS S R MARTINEZ M F J | 2004 | Phytother Res2004，18，5： | 1 |
| 5 | Dollar spot resistance to DMI fungicides显示文摘 | Vargas J M Golembiewski R C Detweiler A R | 1992 | Golf Course Management1992，60，3： | 1 |
| 6 | Juvenile-onset spondyloarthropathies显示文摘 | BURGOS VARGAS R PACHECO TENA C VAZQUEZ MELLADO J | 1997 | Rheum Dis Clin North Am1997，23，3： | 1 |
| 7 | Opiine parasitoids (Hymenoptera: Braconidae) of oriental fruit fly (Diptera:Tephritidae) on Kauai island, Hawaii: islandwide relative abundance and parasitism rates in wild and orchards guava habitats显示文摘 | VARGAS R I SPARK J D UCHIDA G K | 1993 | Environmetal Entomology1993，22，： | 1 |
| 8 | Ecdysteroids from Leuzea carthamoides 显示文摘 | Girault J P Lafont R Varga E | 1988 | Phytochem1988，27，3： | 1 |
| 9 | Response of female melon fly, Bactrocera cucurbitae, to host-associated visual and olfactory stimuli显示文摘 | Pinero J C Jacome I Vargas R | 2006 | Entomologia Experimentalis et Applicata2006，121，： | 1 |
| 10 | Some 2-Periodic Trigonometric Interpolation Problems on EquidistantNodes显示文摘 | SHARMA A SZABADOS J VARGA R S | 1991 | Analysis1991，11，： | 1 |
| 11 | Some 2-periodic trigonometric interpolation problems on equidistant nodes显示文摘 | SHARMA A SZABADOS J VARGA R S | 1991 | Analysis1991，11，： | 1 |
| 12 | How risky is risk assessment:the role that life history strategies play in susceptibility of species to stress显示文摘 | Stark J D Banks J E Vargas R | 2004 | Proc Natl Acad Sci USA2004，101，3： | 1 |
| 13 | Influence of a Spirulina pla tens is biomass on the microflora of fermented ABT milks during storage (R 1)显示文摘 | VARGA L SZIGETI J KOVACS R | 2002 | J Dairy Science2002，85，5： | 1 |
| 14 | Antihypertensive effects of the flavorNoid quereetin in spontaneously hypertensive rats 显示文摘 | Duarte J Perez-Palencia R Vargas F el al | 2001 | Br J Pharmacol2001，133，1： | 1 |
| 15 | 2-periodic Lacunary Trigonometric Interpolation显示文摘 | SHARMA A SZABAIX)S J VARGA R S | 1988 | Constructive Theory of Functions1988，6，3： | 1 |
| 16 | Toxicity and hazard assessment of fipro- nil to Daphnia pulex 显示文摘 | Stark J D Vargas R I | 2005 | Ecotoxicology and Environmental Safety2005，62，1： | 1 |
| 17 | Optimi- zation study and heat transfer comparison of staggered circular and elliptic tubes in forced convection 显示文摘 | Matos R S Vargas J V C Laursen T A | 2001 | International Journal of Heat and Mass Transfer2001，44，20： | 1 |
| 18 | The early clinical recognition of juvenile -onset ankylosing spondylitis and its differentiation from juvenile rheumatoid arthritis 显示文摘 | BURGOS VARGAS R VAZQUEZ MELLADO J | 1995 | Arthritis Rheum1995，38，6： | 1 |
| 19 | Methyl eugenol and cue lure traps for suppression of male oriental fruit flies and melon flies ( Diptera : Tephritidae) in Hawaii: effects of lure mixtures and weathering显示文摘 | Vargas R I Stark J D Kido M D | 2000 | J Econ Entomol2000，93，3： | 1 |
| 20 | Increase of manganese content of cocksfoot (Dactylis glomerata) by fertilization显示文摘 | Tolgyesi G Varga J Schmidt R | 1983 | Magyar Allatorvosok Lapja1983，38，10： | 1 |
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