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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Size-dependent chemical and - moagnetic mrdering in L10-FePt nanoparticles 显示文摘 | Rong C B Li D Vikas N | 2006 | Adv Mater2006，18，： | 1 |
| 3 | Heterozygous em- bryonicstem cell lines derived from nonhuman pri- mate parthenotes显示文摘 | Vikas D Lisa C Darlene P | 2008 | Stem Cells2008，26，： | 1 |
| 4 | Thermally Actuated Shape-memory Polymers: Experiments, Theory and Numeri- cal Simulations 显示文摘 | VIKAS S SHAWN A C LALLIT A | 2010 | Journal of the Mechanics and Physics of Solids2010，58，8： | 1 |
| 5 | Synthesis, Biological Activity and Molecular Modeling of 6-Benzyl?thioinosine Analogues as Subversive Substrates of Toxo?plasma Gondii Adenosine Kinase显示文摘 | VIKAS v CHUNG K C RE etal | 2004 | J Med Chern2004，47，8： | 1 |
| 6 | Performanceanalysis of a multirecess capillary compensated conicalhydrostatic journal bearing显示文摘 | Sharma Satish C Phalle Vikas M Jain S C | 2011 | Tribology International2011，，44： | 1 |
| 7 | Prevalence of dental caries at different levels of fluoride ion concentra- tions among the school children in nalgonda district 显示文摘 | Vikas C Desai MM Rajendra Reddy E | 2013 | Int J Cur Res Rev2013，5，5： | 1 |
| 8 | Speaker localization using excitation source information in speech 显示文摘 | VIKAS C RAYKAR B YEGNANARAYANA S R | 2005 | IEEE Trans Speech Signal Processing2005，13，5： | 1 |
| 9 | Generating fuzzy rules for target tracking using a steady-state genetic algorithm 显示文摘 | KEITH C CHAN C LEE Vika | 1997 | IEEE Trans on Evolutionary Computation1997，1，3： | 1 |
| 10 | CORDIC-based VLSI architecture for real time implementation of fiat top window 显示文摘 | VIKAS K KAILASH C R PREETAM K | 2014 | Microprocessors and Microsystems2014，38，8： | 1 |
| 11 | Genesis and geochemistry of high fluoride beating groundwater from a semi-arid terrain of NW India显示文摘 | VIKAS C KUSHWAHA R AHMAD W | 2013 | Environ Earth Sci2013，68，1： | 1 |
| 12 | Influ-ence of Wear on the Performance of a Muhirecess Conical Hybrid Journal Bearing Compensated with Orifice Restric-tor显示文摘 | SHARMA Satish C PHALLE Vikas M JAIN S C | 2011 | Tribology International2011，，12： | 1 |
| 13 | Per-formance Analysis of a Multirecess Capillary Compensated Conical Hydrostatic Journal Bearing 显示文摘 | SHARMA Satish C PHALLE Vikas M JAIN S C | 2011 | Tribology Inter-national2011，44，5： | 1 |
| 14 | Numerical analysis of a planar anode-supported SOFCwith composite electrodes 显示文摘 | Thinh X Ho T H Kosinski P Hoffmann A C VikA | 2009 | International Journal ofHydrogen Energy2009，34，8： | 1 |
| 15 | Novel approach to synthesis of FePt magnetic nanoparticles 显示文摘 | Kevin E E Girija S C Vikas N | 2008 | j Nano Res2008，，1： | 1 |
| 16 | Safety and performance of the Penumbra Liberty stent system in a rabbit aneurysm model显示文摘 | Rajendra C Stephen P Vikas G | 2015 | J Neurointerv Surg2015，7，： | 1 |
| 17 | Performance analysis of a multirecess capillary compensated conical hydrostatic journal bearing显示文摘 | SATISH C S VIKAS M P JAIN S-C | 2011 | Tribology International2011，44，： | 1 |
| 18 | Liquid phase oxidation of p-cresol over cobalt saponite 显示文摘 | Vikas S Kshirsagar Ajit C Garade Kashinath R Patil | 2009 | Top Catal2009，52，： | 1 |
| 19 | Microbial pigments as natural color sources:current trends and future perspectives显示文摘 | Hardeep S Tuli P C Vikas B | 2015 | Journal of Food Science and Technology2015，52，8： | 1 |
| 20 | Biotransformations using plant cells,organ cultures and enzynle systems:current trends and future prospects显示文摘 | Arehana Giri Vikas Dhingra Girl C C | 2001 | Biotechnology Advances2001，19，3： | 1 |
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