|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | 在诊断 choledochal 包囊的磁性的回声 cholangiopancreatography 的角色: 盒子系列和评论显示文摘 AIM:To determine the merits of magnetic resonance cholangiopancreatography(MRCP) as the primary diagnostic test for choledochal cysts(CC’s).METHODS:Between 2009 and 2012,patients who underwent MRCP for perioperative diagnosis were identified.Demographic information,clinical characteristics,and radiographic findings were recorded.MRCP results were compared with intraoperative findings.A PubMed search identified studies published between 1996-2012,employing MRCP as the primary preoperative imaging and comparing results with either endoscopic retrograde cholangiopancreatography(ERCP) or operative findings.Detection rates for CC’s and abnormal pancreaticobiliary junction(APBJ) were calculated.In addition detection rates for clinically related biliary pathology like choledocholithiasis and cholangiocarcinomas in patients diagnosed with CC’s were also evaluated.RESULTS:Eight patients were identified with CC’s.Six patients out of them had typeⅣCC’s,1 had type I and 1 had a new variant of choledochal cyst with confluent dilatation of the common bile duct(CBD) and cystic duct.Seven patients had an APBJ and 3 of those had a long common-channel.Gallstones were found in 2 patients,1 had a CBD stone,and 1 pancreatic-duct stone was also detected.In all cases,MRCP successfully identified the type of CC’s,as well as APBJ with ductal stones.From analyzing the literature,we found that MRCP has 96%-100% detection rate for CC’s.Additionally,we found that the range for sensitivity,specificity,and diagnostic accuracy was 53%-100%,90%-100% and 56%-100% in diagnosing APBJ.MRCP’s detection rate was 100% for choledocholithiasis and 87% for cholangiocarcinomas with concurrent CC’s.CONCLUSION:After initial ultrasound and computed tomography scan,MRCP should be the next diagnostic test in both adult and pediatric patients.ERCP should be reserved for patients where therapeutic intervention is needed. | Vikas Y Sacher James S Davis Danny Sleeman Javier Casillas | 2013 | World Journal of Radiology2013，5，8： | 15 |
| 3 | The role and significance of Magnesium in modern day research-A review显示文摘Magnesium is one of the largely available elements in the earth’s crust. It has a low structural density with high specific strength. This unique material property has forced an increase in the use of magnesium and its alloys in various applications pertaining to industrial sector,automobiles, aerospace and biomedical. Since magnesium is a highly reactive metal, it is prone to higher rate of corrosion as compared to its counterparts. Thus, it is essential to analyze the corrosion behavior of magnesium and its alloys in its applications. An appropriate process is to be followed in the design and development of magnesium alloys which overcome the limitations of magnesium and enhance the desired material properties in accordance to their applications. This review paper summarizes the importance of magnesium and its material properties. The influence of various alloying elements on the mechanical properties of magnesium is reviewed. The broad classification of Mg alloys and their behavioral trends are detailed. The corrosion behavior of magnesium and the influence of corrosion products on the material characteristics of magnesium, in aqueous medium, are discussed. The manufacturing techniques of magnesium alloys along with the secondary techniques are also covered. The various applications and the limitations of magnesium in these applications are covered. A complete section is dedicated towards detailing the recent trends of magnesium(Mg) alloys, i.e., the biodegradable nature and applications of Mg alloys. The influence of biocorrosion on Mg alloys and techniques to overcome it have been deliberated. This paper provides a thorough review on recent developments of magnesium with respect to engineering applications. | S V Satya Prasad S B Prasad Kartikey Verma Raghvendra Kumar Mishra Vikas Kumar Subhash Singh | 2022 | Journal of Magnesium and Alloys2022，10，1： | 11 |
| 4 | Plasma cathepsin L:A prognostic marker for pancreatic cancer显示文摘AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic cancer.METHODS:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ELISA.Out of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by immunohistochemistry.Survival of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical analysis.RESULTS:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival analysis.Elevated plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate analysis.The plasma levels of the protease decreased after surgery.Though no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in plasma.CONCLUSION:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease. | Nidhi Singh Prasenjit Das Surabhi Gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta Gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 5 | Factors effecting the morphology of eudragit S-100 based microsponges bearing dicyclomine for colonic delivery 显示文摘 | Vikas J Deepika J Ranjit S | 2011 | J Pharmacol Sci2011，100，4： | 1 |
| 6 | Performance analysis of switched reluctance motor; design, modeling and simulation of 8/6 switched reluctance motor 显示文摘 | Vikas S Vadnerkar G Tulasiram Das A D Rajkumar | 2005 | Journal of theoretical and applied information technology2005，，： | 1 |
| 7 | Toxicity and degradability of nitrophenols in anaerobic systems显示文摘 | Uberoi Vikas Bhattacharya S K | 1997 | Water Environment Research1997，69，2： | 1 |
| 8 | Design and characterization of colon- specific drug delivery system containing paracetamol microsponges 显示文摘 | Vikas J Ranjit S | 2011 | Arch Pharm Res2011，34，5： | 1 |
| 9 | A review on detonation gun sprayed coatings 显示文摘 | Lakhwinder S Vikas G Grewal J S | 2012 | Journal of Minerals & Materis Characterization and Engineering2012，11，3： | 1 |
| 10 | Factors effecting the morphology of eudragit S-IO0 based microsponges bearing dicyclomine for colonic delivery 显示文摘 | Vikas J Deepika J Ranjit S | 2011 | J Pharmacol Sci2011，100，4： | 1 |
| 11 | Thermally Actuated Shape-memory Polymers: Experiments, Theory and Numeri- cal Simulations 显示文摘 | VIKAS S SHAWN A C LALLIT A | 2010 | Journal of the Mechanics and Physics of Solids2010，58，8： | 1 |
| 12 | Cataplasm-based controlled drug delivery: Development and optimization of a novel formulation显示文摘 | Vikas A Shailesh K S Indra K R | 1999 | Drug Dev Ind Pharm1999，25，5： | 1 |
| 13 | Performanceanalysis of a multirecess capillary compensated conicalhydrostatic journal bearing显示文摘 | Sharma Satish C Phalle Vikas M Jain S C | 2011 | Tribology International2011，，44： | 1 |
| 14 | A new algorithm for 2-D DOA estimation显示文摘 | Vikas S Kedla Bindu Chandna | 1997 | Signal Processing1997，60，3： | 1 |
| 15 | Macrophage-specific M-ycobacterium tuberculosis genes:identification by green fluorescent protein and kanamycin resistance selection显示文摘 | VIKAS S CARINE R RANJANA S | 2007 | Microbiology2007，153，： | 1 |
| 16 | Speaker localization using excitation source information in speech 显示文摘 | VIKAS C RAYKAR B YEGNANARAYANA S R | 2005 | IEEE Trans Speech Signal Processing2005，13，5： | 1 |
| 17 | Dysfunctional KEAP1- NRF2 Interaction in Non-Small-Cell Lung Cancer显示文摘 | Anju S Vikas M Thimmulappa RK | 2006 | PLoS Med2006，3，10： | 1 |
| 18 | Dissolution and powder flow characterization of solid self-emulsified drug delivery system ( SEDDS )显示文摘 | Vikas A Akhtar S Hazem All | 2009 | Intenlational J of Pharmaceutics2009，366，12： | 1 |
| 19 | Fuzzy application to the analytic hierarchy process for robot selection显示文摘 | VIKAS K SHYAM S T | 2005 | Fuzzy Optimization and Decision Making2005，4，3： | 1 |
| 20 | Gatifloxacin Induces S and G2-Phase Cell Cycle Arrest in Pancreatic Cancer Cells via p21/p27/p53显示文摘 | Vikas Y Sarwat S Jyoti Y | 2012 | PLo S One2012，7，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员