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| 1 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 2 | Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial显示文摘 | S Vincent Rajkumar Susanna Jacobus Natalie S Callander Rafael Fonseca David H Vesole Michael E Williams Rafat Abonour David S Siegel Michael Katz Philip R Greipp | 2010 | Lancet Oncology2010，，1： | 2 |
| 3 | The effect of repeated exposure to particulate air pollution (PM10) on the bone marrow显示文摘 | MUKAE H VINCENT R QUINLAN K | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 4 | Progress in fretting maps显示文摘 | ZHOU Z R NAKAZAWA K ZHU M H MARUYAMA N KAPSA Ph VINCENT L | 2006 | Tribology International2006，39，10： | 1 |
| 5 | Minimizing interceptor size using neural networks for terminal guidance law synthesis显示文摘 | Gottell R G Vincent T L Sadati S H | 1996 | Journal of Guidance Control and Dynamics1996，19，3： | 1 |
| 6 | The effect of training status on the serum creatine kinase response, soreness and muscle function following resistance exercise 显示文摘 | VINCENT H K VINCENT K R | 1997 | Int Sports Med1997，18，6： | 1 |
| 7 | Short- term endotracheal climate changes and clinical effects of a heat and moisture exchanger with an integrated electro- static virus and bacterial filter developed for laryngecto- mized individuals显示文摘 | Scheenstra R J Muller S H Vincent A | 2010 | Acta Otolaryngol2010，130，6： | 1 |
| 8 | Pulmonary toxicity of an atmospheric particulate sample is due to the soluble fraction显示文摘 | Adamson IYR Prieditis H Vincent R | 1999 | Toxicology and Applied Pharmacology1999，157，： | 1 |
| 9 | Macrolactams:A New Class of Antifungal Agents 显示文摘 | Vinod R H Mahesh G P Vincent P G | 1990 | J Am Chem Soc1990，112，： | 1 |
| 10 | Minimizing Interceptor Size Using Neural Networks for Terminal Guidance Law Synthesis显示文摘 | Gottell R G Vincent T L Sadati S H | 1996 | Journal of Guidance Control and Dynamics1996，19，3： | 1 |
| 11 | Minimizing Inter- ceptor Size Using Neural Networks for Terminal Guidance Law Synthesis 显示文摘 | Cottrel R G Vincent T L Sadati S H | 1996 | Journal of Guidance Control and Dy- namics1996，19，3： | 1 |
| 12 | Soluble and insoluble air particle fractions induce differential production of tumor necrosis factor alpha in rat lung显示文摘 | Adamson IY Prieditis H Vincent R | 2004 | Exp Lung Res2004，30，5： | 1 |
| 13 | Salomonsont development of methods for mapping global snow cover using moderate resolution imaging spectrora- diometer data显示文摘 | DOROTHY K H GEORGE A R VINCENT V | 1995 | Remote Sensing of Environment1995，54，2： | 1 |
| 14 | Poly microgel particles:swelling control using pH,cononsolvency and osmotic deswelling显示文摘 | H M Crowther B Vincent | 1997 | Macromolecules1997，30，3： | 1 |
| 15 | Macroinvertebrates of a California seasonal wetland and responses to experimental habitat manipulation显示文摘 | Darold P B Vincent H R | 1992 | Wetland1992，12，1： | 1 |
| 16 | The effect of repeated exposure to particulate air pollution (PM10) on the bone marrow显示文摘 | Mukae H Vincent R Quinlan K | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 17 | Poly microge/ particles: Swelling control using pH, cononsolvency, and osmotic deswelling显示文摘 | Saunders B R Crowther H M Vincent B | 1997 | Macromolecules1997，30，3： | 1 |
| 18 | Fluorous biphasic catalysis:complexation of 1,4,7-[C8F17 (CH2)3]3-1,4,7-triazacyclononane with[M(C8F17(CH2)2CO2)2](M =Mn,Co) to provide perfluoroheptane-soluble catalysts for alkane and alkene functionalization in the presence of t-BuOOH and O2显示文摘 | Vincent J M Rabion A Yachandra V K Fish R H | | 0，，： | 1 |
| 19 | Lead-free reflowsoldering for electronics assembly 显示文摘 | HARRISON M R VINCENT J H STEEN H A H | 2001 | Soldering & Surface MountTechnology2001，13，3： | 1 |
| 20 | Multiple independent emer- gences of type 2 vaccine-derived polioviruses during a large outbreak in northern Nigeria显示文摘 | Burns C C Shaw J Jorba J Bukbuk D Adu F Gumede N Pate M A Abanida E A Gasasira A Iber J Chen Q Vincent A Chenoweth P Henderson E Wannemuehler K Naeem A Umarni R N Nishimura Y Shimizu H Baba M Adeniji A Williams A J Kil- patrick D R Oberste M S Wassilak S G Tomori O Pallansch M A Kew O | 2013 | J Virol2013，87，9： | 1 |
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