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| 1 | 初级保健中原发性醛固酮增多症的患病率和临床表现显示文摘原发性醛固酮增多症(primaryaldosteronism,PA)是一种异质性疾病,以高血压和相对自主于肾素血管紧张素系统产生过量醛固酮为特征。与心血管病风险相似的原发性高血压患者相比,PA患者发生心脑血管并发症的风险以及代谢综合征患病率增加,提示正确诊断PA的重要性。 | Monticone S Burrello J Tizzani D Bertello C Viola A Buffolo F Gabetti L Mengozzi G Williams TA Rabbia F Veglio F Mulatero P 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 58 |
| 2 | Sonography of the small intestine显示文摘In the last two decades, there has been substantial development in the diagnostic possibilities for examining the small intestine. Compared with computerized tomography, magnetic resonance imaging, capsule endoscopy and double-balloon endoscopy, ultrasonography has the advantage of being cheap, portable, flexible and user-and patient-friendly, while at the same time providing the clinician with image data of high temporal and spatial resolution. The method has limitations with penetration in obesity and with intestinal air impairing image quality. The flexibility ultrasonography offers the examiner also implies that a systematic approach during scanning is needed. This paper reviews the basic scanning techniques and new modalities such as contrast-enhanced ultrasound, elastography, strain rate imaging, hydrosonography, allergosonography, endoscopic sonography and nutritional imaging, and the literature on disease-specific findings in the small intestine. Some of these methods have shown clinical benefit, while others are under research and development to establish their role in the diagnostic repertoire. However, along with improved overall image quality of new ultrasound scanners, these methodshave enabled more anatomical and physiological changes in the small intestine to be observed. Accordingly, ultrasound of the small intestine is an attractive clinical tool to study patients with a range of diseases. | Kim Nylund Svein Фdegaard Trygve Hausken Geir Folvik Gülen Arslan Lied Ivan Viola Helwig Hauser Odd-Helge Gilja | 2009 | World Journal of Gastroenterology2009，15，11： | 9 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Advanced imaging and visualization in gastrointestinal disorders显示文摘Advanced medical imaging and visualization has a strong impact on research and clinical decision making in gastroenterology. The aim of this paper is to show how imaging and visualization can disclose structural and functional abnormalities of the gastrointestinal (GI) tract. Imaging methods such as ultrasonography, magnetic resonance imaging (MRI), endoscopy, endosonography, and elastography will be outlined and visualization with Virtual Reality and haptic methods. Ultrasonography is a versatile method that can be used to evaluate antral contractility, gastric emptying, transpyloric flow, gastric configuration, intragastric distribution of meals, gastric accommodation and strain measurement of the gastric wall. Advanced methods for endoscopic ultrasound, three-dimensional (3D) ultrasound, and tissue Doppler (Strain Rate Imaging) provide detailed information of the GI tract. Food hypersensitivity reactions including gastrointestinal reactions due to food allergy can be visualized by ultrasonography and MRI. Development of multi-parametric and multi-modal imaging may increase diagnostic benefits and facilitate fusion of diagnostic and therapeutic imaging in the future. | Odd Helge Gilja Jan G Hatlebakk Svein φdegaard Arnold Berstad Ivan Viola Christopher Giertsen Trygve Hausken Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，9： | 2 |
| 5 | Molecular stability of chemically modified collagen triple helices显示文摘 | Giudici G Viola M | 2003 | Federation of Eu ropean Biochemical Societies2003，547，3： | 1 |
| 6 | Autonomic modulator and QT in-terval dispersion in hypertensive subjects withanxiety显示文摘 | Piccirillo G Viola E Nocco M | 1999 | Hypertension1999，34，： | 1 |
| 7 | Autonomic modulator and QT intenal dispersion in uypertensive subjects with anxiety显示文摘 | Piccirillo G Viola E Nocco M | 1999 | J Hypertension1999，34，2： | 1 |
| 8 | Ras p21 expression in the progression of breast cancer显示文摘 | Romowitz FB Viola MV Chao S Oravez S Mishriki Y Finkel G | 1987 | Hum Pathol1987，18，12： | 1 |
| 9 | From TCR engagement to T cell activation:a kinetic view of T cell behavior显示文摘 | Lanzavecchia A Lezzi G Viola A | 1999 | Cell1999，96，： | 1 |
| 10 | Autonomic modulator and QT in-tervaldispersion in hypertensive subjects with anxiety显示文摘 | Piccirillo G Viola E Nocco M | 1999 | Hypertension1999，34，2： | 1 |
| 11 | Nceadjuvant endocrine therapy for locally advanced breast cancer显示文摘 | Viola G Sergi D Conti F | 2007 | Clin Ter2007，158，5： | 1 |
| 12 | Influence of aging on cardiac baroreflex sensitivity determined non - invasively by power spectral analysis 显示文摘 | Piccirillo G Cacciafesta M Viola E | 2001 | Clin Sci( Lond)2001，100，3： | 1 |
| 13 | Tuberization in Potato Involves a Switch from Apoplastic to Symplastic Phloem Unloading显示文摘 | VIOLA R ROBERTS A G HAUPT S | 2001 | Plant Cell2001，13，2： | 1 |
| 14 | Signal transducer and activator of transcription and sphingomyelin metabolism in intranuclear complex during cell proliferation 显示文摘 | Rossi G Viola Magni M Albi E | 2007 | Arch BiochemBiophys2007，464，1： | 1 |
| 15 | Prevention by fructose1, 6-diphosphate of cardiac oxidative damage induced in mice by subchronic doxorubicin treatment显示文摘 | Lazzarino G Viola AR Mulieri L | 1987 | Cancer Res1987，47，： | 1 |
| 16 | Acute kidney injury in cirrhosis 显示文摘 | GARCICA -TSAO G PARIKH CR VIOLA A | 2008 | Hepatology2008，48，6： | 1 |
| 17 | When Strangers Pass: Processing of Mutual and Averted Social Gaze in the Superior Temporal Sutcus 显示文摘 | Pelphrey K A Viola R J McCarthy G | 2004 | Psychological Science2004，15，： | 1 |
| 18 | Brain Na^+ , K^+ -ATPase isoforms: different hypothalamus and mesencephalon response to acute desipramine treatment显示文摘 | Viola M S Rodriguez-de Lores-Arnaiz G | 2007 | Life Sci2007，81，3： | 1 |
| 19 | ras p21 expression in the progression of breast cancer显示文摘 | Fromowitz F B Viola M V Chao S Oravez S Mishriki Y Finkel G | 1987 | Hum Pathol1987，18，： | 1 |
| 20 | Xan- thones from Polygala alpestris (Rchb)显示文摘 | Dall'Acqua S Viola G Cappelletti E M | 2004 | Z Naturfor- sch C2004，59，56： | 1 |
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