|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 2 | Is leasing greener than selling? 显示文摘 | Agrawal Vishal V Ferguson M Toktay L B | 2011 | Management Science2011，57，10： | 1 |
| 3 | Clinical benefit of palliation therapy in advanced gastric cancer显示文摘 | Michelle M Vishal Rana Nom A | 2008 | Acta Oncologica2008，47，3： | 1 |
| 4 | Forecasting the effects of non- linear shipping and handling fees 显示文摘 | LEWIS M VISHAL S SCOTT F | 2003 | Journal of Marketing Re- search2003，18，3： | 1 |
| 5 | The natural history of renal stone fragments following ureteroscopy 显示文摘 | DAVID A R AMANDA M VISHAL B | 2011 | Urology2011，77，3： | 1 |
| 6 | Compressed synthetic aperture radar 显示文摘 | VISHAL M P GLENN R E DENNIS M H RAMA C | 2010 | IEEE Journal of Selected Topics in Signal Processing2010，4，2： | 1 |
| 7 | An analysis of generalized slotted-Aloha protocols 显示文摘 | RICHARD T B M VISHAL M DAN R | 2009 | IEEE/ACM Transactions on Networ- king2009，17，3： | 1 |
| 8 | Gradient based real time spectrum sens- ing at low SNR显示文摘 | SANTASRIL K VISHAL M | 2015 | IEEE Letters on Communications2015，19，3： | 1 |
| 9 | Identifying aspects of neighbour-hood deprivation associated with increased incidence of schizophre-nia显示文摘 | Vishal B Jane B Robin M | 2014 | Schizoph Res2014，156，1： | 1 |
| 10 | Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity显示文摘 | Kartik Shankar Vishal S Vaidya Tao Wang Thomas J Bucci Harihara M Mehendale | 2003 | Toxicology and Applied Pharmacology2003，，2： | 1 |
| 11 | WDR36 variants in East Indian primary open-angle glaucoma patients 显示文摘 | Mookherjee S Chakraborty S Vishal M | 2011 | Mol Vis2011，17，： | 1 |
| 12 | Waveband switching in optical networks显示文摘 | Cao X J Anand Vishal Qiao C M | 2003 | IEEE Communications Magazine2003，41，4： | 1 |
| 13 | The force required to rupture fetal membranes paradoxically increases with acute in vitro repteated stretching显示文摘 | Kellie J Robert M | 2007 | Am J Obstet Gynecol2007，196，： | 1 |
| 14 | Genetics of P450 oxidoreductase:Sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations显示文摘 | Ningwu H Vishal A Kathleen M | | 0，，： | 1 |
| 15 | Joint sparse representation for robust multimodal biometrics re- cognition 显示文摘 | Sumit Shekhar Vishal M Patel Nasser M Nasrabadi | 2014 | IEEE Transactions on Pattern Analysis and Ma- chine Intelligience2014，36，1： | 1 |
| 16 | An Econometric Analysis of Inventory Turnover Performance in Retail Services显示文摘 | Vishal Gaur Fisher M L Raman A | 2005 | Management Science2005，51，2： | 1 |
| 17 | Cooling techniques for improved productivity in turning显示文摘 | Vishal S Sharma Manu Dogra Suri N M | | 0，，： | 1 |
| 18 | Example-driven Manifold Priors for Image Deconvolution显示文摘 | Jie Ni Pavan Turaga M Vishal | 2011 | IEEE Transactions on Image Process- ing2011，，11： | 1 |
| 19 | SAR automatic target recognition using discriminative graphical models显示文摘 | MAMAHESH S VISHAL M RAJ Raghu G | 2014 | IEEE Transactions on Aerospace and Electronic Systems2014，50，1： | 1 |
| 20 | Sparsity-motivated automatic target recognition显示文摘 | Patel Vishal M Nasrabadi Nasser M Chellappa Rama | 2011 | Applied Optics2011，50，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员