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| 1 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 2 | Projectile i- dentification and impact point prediction 显示文摘 | VISHAL C R YAAKOV B S PETER W | 2010 | IEEE Transactions on Aerospace and Electronic Systems2010，46，4： | 1 |
| 3 | The natural history of renal stone fragments following ureteroscopy 显示文摘 | DAVID A R AMANDA M VISHAL B | 2011 | Urology2011，77，3： | 1 |
| 4 | Prevalence of' cardiovascular risk factors in postmenopausal women: A rural study 显示文摘 | Vishal R Tandon Annil Mahajan Sudhaa Sharma | 2010 | J Midlife Heahh2010，1，1： | 1 |
| 5 | Mixture design as a first step for optimization of fermentation medium for cutinase production from Colletotrichum lindemuthianum 显示文摘 | FRED J R VISHAL S | 2007 | Journal of Industrial Microbiology & Biotechnology2007，34，5： | 1 |
| 6 | Compressed synthetic aperture radar 显示文摘 | VISHAL M P GLENN R E DENNIS M H RAMA C | 2010 | IEEE Journal of Selected Topics in Signal Processing2010，4，2： | 1 |
| 7 | An analysis of generalized slotted-Aloha protocols 显示文摘 | RICHARD T B M VISHAL M DAN R | 2009 | IEEE/ACM Transactions on Networ- king2009，17，3： | 1 |
| 8 | Development and Validation of Improved RP-HPLC method for Identification and Estimation of Ellagic and Gallic acid in Triphala churna显示文摘 | PATEL MADHAVI G PATEL VISHAL R PANTEL RAKESH K | 2010 | International Journal of Chem Tech Research2010，2，3： | 1 |
| 9 | A structural neural system for real-time health monitoring of composite materials 显示文摘 | Goutham R Kirikera Vishal Shinde Mard J Schulz | 2008 | Structural Health Monitoring2008，7，1： | 1 |
| 10 | Monitoring multi- site damage growth during quasi- static testing of a wind turbine blade using a structural neural system显示文摘 | Goutham R K Vishal S Mark J S | 2008 | Structural Health Monitoring2008，7，2： | 1 |
| 11 | Monitoring multi-site damage growth during quasi-static testing of a wind turbine blade u- sing a structural neural system 显示文摘 | Goutham R K Vishal S Mark J S | 2008 | Structural Health Monitoring2008，7，2： | 1 |
| 12 | Spontaneous Peri-Nephric He- matoma in a Patient with Acute Kidney Injury Following Rus- sell's Viper Envenomation显示文摘 | Vishal G Arpita R Rajendra P | 2015 | Saudi Journal of Kidney Diseases and Transplantation2015，26，2： | 1 |
| 13 | Postopera- tive radiotherapy for advanced medullary thyroid cancer- local disease control in the modern era显示文摘 | Schwartz D L Vishal R Stephanie S | 2008 | Head & Neck2008，30，7： | 1 |
| 14 | Selective synthesis of alky poly-β-d-glucopyranoside over mixed metal oxide显示文摘 | Nivedita S Chaubal Vishal Y Joshi Manohar R Sawant | 2007 | Journal of Molecular Catalysis A2007，267，12： | 1 |
| 15 | Monitoring multisite damage growth during quasi-static testing of a wind turbine blade using a structural neural system 显示文摘 | Goutham R K Vishal S Mark J S | 2008 | Structural Health Monitoring2008，7，2： | 1 |
| 16 | Effect of organic zinc sup-plementation on growth,nutrient utilization and mineral profilein lambs显示文摘 | Garg A K Vishal Mudgal Dass R S | 2008 | Animal Feed Science and Technology2008，144，1： | 1 |
| 17 | Postoperative radiotherapy for advanced medullary thyroid cancer-local disease control in the modern era 显示文摘 | SCHWARTZ D L VISHAL R STEPHANIE S | 2008 | Head Neck2008，30，： | 1 |
| 18 | Monitoring multi-site damage growth during quasi-static testing of a wind turbine blade using a structural neural system显示文摘 | GOUTHAM R K VISHAL S MARK J S | 2008 | Structural Health Monitoring2008，7，2： | 1 |
| 19 | Montioring multisite danmge growth during quasi-satic testing of a wind turbine blades using a structural neura system 显示文摘 | Goutham R K Vishal S Mark J S | 2008 | Structural Health Montioring2008，7，2： | 1 |
| 20 | Target Delineation in High-grade Glioma Do CTV Margins Make a Difference? ESTRO ACROP versus RTOG Guidelines a Comparative Dosimetric Study显示文摘Background and purpose:There exist two major consensus guidelines for target delineation in glioblastoma(GBM).Namely the established radiation therapy oncology group(RTOG)and the recently redefined European society for radiation oncology(EORTC)-advisory committee on radiation oncology practice(ACROP),clinical studies evaluating the pattern of recurrence with relation to the CTV margins have as of date not evidenced statistically significant difference in relation to the two guidelines.However,considering the standardization of concurrent chemo-radiation with Temozolomide nearly 20%off patients can be expected to survive 2years or beyond.Quality of life issues will play a higher role in defining the better protocol.In the current study,we have dosimetrically compared these guidelines in both perspectives.Material and methods:Thirty patients of GBM who had been planned for conformal radiotherapy during Jan 2017 to Feb 2019 were considered.Each patient dataset contoured with ESTRO-ACROP guidelines to create PLAN A and RTOG guidelines to create PLAN B.Both plans were compared to evaluate the volumetric difference in terms of PTV and the relative proximity to critical normal structures.Results:The median volume of brain irradiated to high doses(60Gy)was significantly greater in PLAN B,566cc vs 398 cc(P<0.0002).The organs at risk were better spared with PLAN A in terms of encroachment of high dose PTV volume.This achieved significance for Brainstem(P<0.01),Chiasma(P<0.04)and hippocampus(P<0.016).We were able to identify patients with PTV volume>400cc and with tumor in Parietal or Temporal regions wouldn’t benefit from PLAN A.Conclusion:The use of target delineation based on a single step plan,excluding expanded edema(ESTRO-ACROP)could potentially reduce high dose target volumes and significantly spare brainstem,optic-chiasma,and hippocampus.Patients with tumor volume<400 cc and frontal lesions are most likely to benefit. | Bindhu Joseph Vishal Malavade Nisarga V M Vijay C R Ramesh C Lokesh Vishwanath | 2018 | Advances in Modern Oncology Research2018，4，6： | 0 |
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