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| 1 | Antimicrobial activity,cytotoxicity,and phytochemical screening of Voacanga globosa(Blanco) Merr.leaf extract(Apocynaceae)显示文摘Objective:To determine the antibacterial,antifungal,antiprotozoal,cytotoxic,and phytochemical properties of ethanol extracts of leaves of Voacanga globosa(Blanco) Merr.(V.globosa). Methods:The extracts were tested against bacteria and fungus through disc diffusion assay; against protozoa through growth curve determination,antiprotozoal and cytotoxicity assays. Results:The extract revealed antibacterial activities,inhibiting the growth of Staphylococcus aureus,Bacillus cereus,Pseudomonas aeruginosa,Micrococcus luteus,and Salmonella typhimurium.Antifungal assay showed that it inhibited Candida albicans.The antiprotozoal assay against Trichomonas vaginalis and Entamoeba histolytica showed that V.globosa can inhibit the parasites,wherein the action can be comparable to metronidazole.With the in situ cell death detection kit.Trichomonas vaginalis and Entamoeba histolytica exposed to V.globosa leaf extract was observed to fluoresce simultaneously in red and yellow signals signifying apoptotic-like changes.Preliminary phytochemical screening revealed the chemical composition of plant extract containing alkaloids,saponins,2-deoxysugars,and hydrolysabie tannins.Conclusions: Thus,thus study provides scientific evidence on the traditional use of V.globosa leaf extract in treating microbial diseases.Further,the leaf extract can possibly be used to produce alternative forms of antimicrobials. | Pierangeli G Vital Windell L Rivera | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 5 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Detection of Mycobacterium tuberculosis complex in cattle by PCR using milk,lymph node aspirate,and nasal swabs显示文摘 | Vitale F Capra G Maxia L | 1998 | Journal of Clinical Microbiology1998，36，4： | 1 |
| 4 | Idiopathic normal-pressure hydrocephalus in adults:result of shunting correlated with clinical findings in 18 patients and review of the literature显示文摘 | Caruso R Cervoni L Vitale AM | | 0，，02： | 1 |
| 5 | Detection of mycobacterium tuberculosis complex in cattle by PCR using milk, lymph node, aspirates, and nasal swaps 显示文摘 | Vitale F Capra G Maxia L | 1998 | Journal of Clinical Microbiology1998，36，4： | 1 |
| 6 | Recombinant human GAD65 accumulates to high levels in transgenic tobacco plants when expressed as an enzymatically inactive mutant 显示文摘 | Avesani L Vitale A Pedrazzini E | 2010 | Plant Biotechnol J2010，8，8： | 1 |
| 7 | Levosimendan pre-treat- ment improves outcomes in patients undergoing coronary artery bypass graft surgery显示文摘 | Tritapepe L De Santis V Vitale D | 2009 | Br J Anaesth2009，102，2： | 1 |
| 8 | Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66shc Gene显示文摘 | Marcello Rota Nicole LeCapitaine Toru Hosoda Alessandro Boni Antonella De Angelis Maria Elena Padin-Iruegas Grazia Esposito Serena Vitale Konrad Urbanek Claudia Casarsa Marco Giorgio Thomas F. Lüscher Pier Giuseppe Pelicci Piero Anversa Annarosa Leri Jan | 2006 | Circulation Research2006，，1： | 1 |
| 9 | Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves显示文摘 | VITALE N DE FEO M DE SANTO L S | 1999 | J Am Coll Cardiol1999，33，6： | 1 |
| 10 | Novel synthesis of 3, 4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal显示文摘 | Di N L Vitale P Scilimati A | 2004 | JMed Chem2004，47，20： | 1 |
| 11 | Ablating the ventricular insertion of atrio-fascicular Mahaim fiber:what selection criteria should we use显示文摘 | Ducceschi V Vitale R Ottaviano L | | 0，，03： | 1 |
| 12 | Diagnosis and classification of relapsing polychondritis显示文摘 | Cantarini L Vitale A Brizi M G | 2014 | J Autoimmun2014，4849，2： | 1 |
| 13 | Dose-dependem fetal complications of war farin in pregnant women with me chanical heart valves 显示文摘 | Vitale N DeFeoM De Santo L S | 1999 | J Am Coll Cardiol1999，33，6： | 1 |
| 14 | Restaging locally advanced rectal cancer with MRimaging after chemoradiation therapy 显示文摘 | BARBARO B VITALE R LECCISOTTI L | 2010 | Radiographics2010，30，3： | 1 |
| 15 | Body position changes redistribute lung computed tomographic density in patients with acute respiratory failure显示文摘 | GATTINONI L PELOSI P VITALE G | 1991 | Anesthesiology1991，74，1： | 1 |
| 16 | Preva- lence of malnutrition in general medical patients显示文摘 | BRUCE R S BLACKBURN G L VITALE J | 1976 | JAMA1976，235，4： | 1 |
| 17 | Ablating the ventricular insertion of atrio-fascicular Mahaim fiber: what selection criteria should we use? 显示文摘 | Ducceschi V Vitale R Ottaviano L | 2009 | J Interv Card Electrophysiol2009，25，： | 1 |
| 18 | Positional asphyxia:reflection on 2cases显示文摘 | Belviso M De Donno A Vitale L | 2003 | Am J Forensic Med Pathol2003，24，3： | 1 |
| 19 | Treatment of acute respiratory failure secondary to pulmonary edema with bilevel positive airway pressure by nasal mask显示文摘 | L O COCO A VITALE G MARCHESE S | 1997 | Monaldi Arch Chest Dis1997，52，5： | 1 |
| 20 | Prospective colonoscopyafter self-expandable metallic stent pacement in patients with a-cute neoplastic colon obstruction显示文摘 | Vitale MA Villontti G D'Alba L | 2006 | Gastrointest Endosc2006，63，： | 1 |
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