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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress显示文摘 | Vitale M Di Matola T D'Ascoli F | 2000 | Endocrinology2000，141，2： | 1 |
| 3 | Plasma levels of inflammatory C-reactive protein and interleukin-6 predict outcome in elderly patients with stroke显示文摘 | Silvestri A Vitale C Ferretti F | 2004 | J Am Geriatr Soc2004，52，： | 1 |
| 4 | Detection of Mycobacterium tuberculosis complex in cattle by PCR using milk,lymph node aspirate,and nasal swabs显示文摘 | Vitale F Capra G Maxia L | 1998 | Journal of Clinical Microbiology1998，36，4： | 1 |
| 5 | Prognostic impact of model for end-stage liver disease score in patients undergoing liver transplantation with suboptimal livers显示文摘 | Vitale A DAmico F Brolese A et at | 2007 | Transplant Proc2007，39，6： | 1 |
| 6 | Iodide excess induces apoptosis in thyroid cells through a p53-independ- ent mechanism involving oxidative stress 显示文摘 | Vitale M Di Matola T D'Ascoli F | 2000 | Endocrinol- ogy2000，141，2： | 1 |
| 7 | Clinical significance of alphafetoproteinmRNA in blood of patients with hepatocellular carcinoma显示文摘 | Cillo U Navaglia F Vitale A | 2004 | Clin Chim Acta2004，347，12： | 1 |
| 8 | Detection of mycobacterium tuberculosis complex in cattle by PCR using milk, lymph node, aspirates, and nasal swaps 显示文摘 | Vitale F Capra G Maxia L | 1998 | Journal of Clinical Microbiology1998，36，4： | 1 |
| 9 | Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress显示文摘 | VITALE M DIMATOLA T DASCOLI F | 2000 | Endocrinology2000，141，2： | 1 |
| 10 | Plasma levels of inflammatory C- reactive protein and interleukin-6 predict outcome in elderly patients with stroke 显示文摘 | Silvestri A Vitale C Ferretti F | 2004 | J Am Geriatr Soc2004，52，9： | 1 |
| 11 | Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress显示文摘 | Vitale M Matola TD Dascoll F | 2000 | Endocrinology2000，141，： | 1 |
| 12 | Plasma levels of inflammatory C-reactive protein and intcrleukin-6 predict outcome in elderly patients with stroke 显示文摘 | Silvcstri A Vitale C Ferretti F | 2004 | J Am Geriatr Soc2004，52，： | 1 |
| 13 | Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress显示文摘 | Vitale M Di Matola T D'Ascoli F | 2000 | Endocrinology2000，141，2： | 1 |
| 14 | Asymmetric T5 Pedicle Subtraction Os- teotomy (PSO)for complex posttraumatic deformity 显示文摘 | Obeid I Laouissal F Vital JM | 2013 | European Spine Journal2013，22，9： | 1 |
| 15 | Panax notognseng (Burk) effects fibrinogen and lipid plasma lever in rats fed on a high-fat diet 显示文摘 | Cicero A F Vitale G Savion G | 2003 | Phytother Res2003，17，2： | 1 |
| 16 | The application of Russell and Burch 3R principle in rodent models of neurodegenerative disease: the case of Parkinson's disease 显示文摘 | Manciocco A Chiarotti F Vitale A | 2009 | Neurosci Biobehav Rev2009，33，1： | 1 |
| 17 | Plasma levels of inflammatory C-reactive protein and interleukin-6 predict outcome in eldedy patients with stroke显示文摘 | Silvestfi A Vitale C Ferretti F | 2004 | J Am Geriatr Soc2004，52，9： | 1 |
| 18 | STEP(satellite test of the equivalence principle)显示文摘 | Sumner T J Anderson J Blaser J P Cruise A M Damour T Dittus D Everitt C W F Fou-lon B Jafry Y Kent B J Lockerbie N Loeffler F Mann G Mester J Pegrum C ReinhardtR Sandford M Scheicher A Speake C C Torii R Theil S Touboul P Vitale S Vodel W Worden P W | 2007 | Advance in Space Re-search2007，39，2： | 1 |
| 19 | Dry eye signs and symptoms in women with premature ovarian failure 显示文摘 | Smith J A Vitale S Reed G F | 2004 | Arch Ophthalmol2004，122，： | 1 |
| 20 | Plasma levels of inflamma- tory C-reactive protein and interleukin-6 predict outcome in elder ly patients with stroke显示文摘 | Silvestri A Vitale C Ferretti F | 2004 | J Am Gefiatr Soc2004，52，9： | 1 |
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