|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: The follow-up study of gastrointestinal cancer patients显示文摘AIM: To study the influence of tumor removal on the serum level of IgG antibodies to tumor-associated Thomsen-Friedenreich (TF), Tn carbohydrate epitopes and xenogeneic αGal, and to elucidate on the change of the level during the follow-up as well as its association with the stage and morphology of the tumor and the values of blood parameters in gastrointestinal cancer. METHODS: Sixty patients with gastric cancer and 34 patients with colorectal cancer in stages Ⅰ-Ⅳ without distant metastases were subjected to follow- up. The level of antibodies in serum was determined by the enzyme-linked immunosorbent assay (ELISA) using synthetic polyacrylamide (PAA) glycoconjugates. Biochemical and haematological analyses were performed using automated equipment. RESULTS: In gastrointestinal cancer, the TF antibody level was found to have elevated significantly after the removal of G3 tumors as compared with the preoperative level (u = 278.5, P < 0.05). After surgery, the TF and Tn antibody level was elevated in the majority of gastric cancer patients (sign test, 20 vs 8, P < 0.05, and 21 vs 8, P < 0.05, respectively). In gastrointestinal cancer, the elevated postoperative level of TF, Tn and αGal antibodies was noted in most patients with G3 tumors (sign test, 22 vs 5, P < 0.01; 19 vs 6, P < 0.05; 24 vs 8, P < 0.01, respectively), but the elevation was not significant in patients with G1 + G2 resected tumors. The postoperative follow-up showed that the percentage of patients with G3 resected tumors of the digestive tract, who had a mean level of anti-TF IgG above the cut- off value (1.53), was significantly higher than that of patients with G1 + G2 resected tumors (χ2 = 3.89, all patients; χ2 = 5.34, patients without regional lymph node metastases; P < 0.05). The percentage of patients with a tumor in stage I, whose mean anti-TF IgG level remained above the cut-off value (1.26), was significantly higher than that of patients with the cancer in stages Ⅲ-Ⅳ (χ2 = 4.71, gastric cancer; χ2 = 4.11, gastrointestinal cancer; P < 0.05). The correlation was observed to exist between the level of anti-TF IgG and the count of lymphocytes (r = 0.517, P < 0.01), as well as between the level of anti- Tn IgG and that of serum CA 19-9 (r = 0.481, P < 0.05). No positive delayed-type hypersensitivity reaction in skin test challenges with TF-PAA in any of the fifteen patients, including those with a high level of anti-TF IgG, was observed. CONCLUSION: The surgical operation raises the level of anti-carbohydrate IgG in most patients, especially in those with the G3 tumor of the gastrointestinal tract. The follow-up demonstrates that after surgery the low preoperative level of TF antibodies may be considerably increased in patients with the carcinoma in its early stage but remains low in its terminal stages. The stage- and morphology-dependent immunosuppression affects the TF-antibody response and may be one of the reasons for unresponsiveness to the immunization with TF-antigens. | Eugeniy P Smorodin Oleg A Kurtenkov Boris L Sergeyev Kristel E Kodar Valentin I Chuzmarov Vladimir P Afanasyev | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 2 | N-nitrosodimethylamine formation by ffee2chlorine2emhanced nitrosation of dimethylamine 显示文摘 | Choi J Valentine I L | 2003 | Environmental Science & Technology2003，37，21： | 1 |
| 3 | Effect of single-walled carbon nanotube incorporation on the cure reaction of epory resin and its detection by Ram an spectroscopy显示文摘 | Pug lia D Valentin I L A menteno I | 2003 | Diam and Rela M2003，12，： | 1 |
| 4 | Novel experimental approach to evaluate filler-elastomer interactions 显示文摘 | VALENTIN J L MAOR-BARRANTE I CARRETEROGONZALEZ J | 2010 | Macromolecules2010，43，1： | 1 |
| 5 | Imaging in gynecologi- cal disease (7) :clinical and ultrasound features of Brenner tumors of the ovary 显示文摘 | Dierickx I Valentin L Van Holsbeke C | 2012 | Ultrasound Obstet Gynecol2012，40，： | 1 |
| 6 | Natural killer cell cytotoxic activity in critical pediatric patients with suspected he- mophagocytic syndrome 显示文摘 | Martinez I Fernandez L Valentin J | 2015 | Medicina intensiva2015，39，4： | 1 |
| 7 | Patterns of normal change in cervical length and width during pregnancy in nulliparous women: a prospective, longitudinal ultrasound study 显示文摘 | Bergelin I Valentin L | 2001 | Ultrasound Obstet Gynecol2001，18，3： | 1 |
| 8 | Normal cervical changes in parous women during the second half of pregnancy a prospective,longitudinal ultrasound study显示文摘 | Bergelin I Valentin L | 2002 | Acta Obstet Gynecol Scand2002，81，1： | 1 |
| 9 | Identification and study of a Candida albicans pro-tein homologous to Sacckaromyces cerevisiae Ssrlp,an internalcell-wall protein显示文摘 | Garcera A Martinez A I Castillo L Elorza M V Sentandreu R Valentin E | 2003 | Microbiology?2003，149，8： | 1 |
| 10 | Uncertainties in the determination of cross-link density by equilibrium swelling experiments in natural rubber显示文摘 | Valentin J L Carretero-Gonzfilez J Mora-Barrantes I | 2008 | Macromoleeules2008，41，13： | 1 |
| 11 | Electrochemical performance of Klason lignin as a low-cost cathode-active material for primary lithium battery显示文摘A few classes of organic compounds are promising electrode-active materials due to their high power and energy densities,low cost,environmental friendliness,and functionality.In the present work,the possibility of using Klason lignin extracted from buckwheat husks as a cathode-active material for a primary lithium battery has been investigated for the first time.The reaction mechanism in the lithium/lignin electrochemical cell was suggested based on the deep galvanostatic discharge(up to 0.005 V) data and cyclic voltammetry results.The dependence of the electrochemical behavior of the Klason lignin on the milling degree was evaluated.The maximum specific capacity of the lignin is equal to 600 m Ah g-1at a discharge current density of 75 μA cm-2.Beneficial effect of the thermal treatment of the Klason lignin cathode at250°C on the cell performance was established.It was found that the discharge capacity of the cell increased by 30% in the range from 3.3 to0.9 V for the treated cathode material.These results demonstrate the prospects of using Klason lignin-based electrochemical cells as low-rate primary power sources. | Sergey V Gnedenkov Denis P Opra Ludmila A Zemnukhova Sergey L Sinebryukhov Iliya A Kedrinskii Olga V Patrusheva Valentin I Sergienko | 2015 | Journal of Energy Chemistry2015，24，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员