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| 1 | Regulators and mediators of radiation-induced fibrosis: Gene expression profiles and a rationale for Smad3 inhibition显示文摘 | Lee J W Zoumalan RA Valenzuela CD | 2010 | Otolaryngol Head Neck Surg2010，143，4： | 1 |
| 2 | Base modification strategies to modulate immune stimulation by an siRNA显示文摘 | Valenzuela RA Suter SR Ball - Jones AA | 2015 | Chembiochem2015，16，2： | 1 |
| 3 | Modeling the adsorption and precipitation processes of Cu( Ⅱ ) on humin 显示文摘 | ALVAREZ -- PUEBLA RA VALENZUELA - CALAHORRO C GARRIDO J J | 2004 | Journal of colloid and interface science2004，277，： | 1 |
| 4 | De- tection algorithm and initial laboratory results using V- BLAST space-time communication architecture显示文摘 | Golden G D Foschini G J Valenzuela RA | 1999 | Elec- tronics Letters1999，，： | 1 |
| 5 | Nutritional condition irl chronic renal failure Patiens treated by hemordialysis in Amazonas 显示文摘 | Valenzuela Ra ailfoni AG Cuppari I et aI | 2003 | Rev Assoc Med Bed Bras2003，49，1： | 1 |
| 6 | HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin显示文摘AIM:To analyze hepatitis C virus(HCV)-specific immune responses in chronically infected patients under triple therapy with interferon-α(IFN-α)plus ribavirin and CIGB-230.METHODS:CIGB-230 was administered in different schedules with respect to IFN-αplus ribavirin therapy.Paired serum and peripheral blood mononuclear cells(PBMC)samples from baseline and end of treatment were analyzed.The HCV-specific humoral response was tested by enzyme-linked immunosorbent assay,neutralizing antibodies were evaluated by cell culture HCV neutralization assays,PBMC proliferation was assayed by carboxyfluorescein succinimidyl ester staining and IFN-γsecretion was assessed by enzyme-linked immunospot.Data on virological and histological response and their association with immune variables are also provided.RESULTS:From week 12 to week 48,all groups of patients showed a significant reduction in mean leukocyte counts.Statistically significant reductions in antibody titers were frequent,but only individuals immunized with CIGB-230 as early add-on treatment sustained the core-IgG response,and the neutralizing antibody response was enhanced only in patients receiving CIGB-230.Cell-mediated immune responses also tended to decline,but significant reductions in IFN-γsecretion and total absence of core-specific lymphoproliferation were exclusive of the control group.Only CIGB-230-immunized individuals showed de novo induced lymphoproliferative responses against the structural antigens.Importantly,it was demonstrated that thequality of the CIGB-230-induced immune response depended on the number of doses and timing of administration in relation to the antiviral therapy.Specifically,the administration of 6 doses of CIGB-230 as late addon to therapy increased the neutralizing antibody activity and the de novo core-specific IFN-γsecretion,both of which were associated with the sustained virological response.CONCLUSION:CIGB-230,combined with IFN-α-based therapy,modifies the immune response in chronic patients.The study provides evidence for the design of more effective therapeutic vaccine interventions against HCV. | Yalena Amador-Caizares Gillian Martínez-Donato Liz lvarez-Lajonchere Claudia Vasallo Mariacarla Dausá Daylen Aguilar-Noriega Carmen Valenzuela Ivette Raíces Jean Dubuisson Czeslaw Wychowski Zurina Cinza-Estévez Marlén Castellanos Magdalys Núez Anny Armas Yaimé González Ismariley Revé Ivis Guerra ngel Pérez Aguiar Santiago Dueas-Carrera | 2014 | World Journal of Gastroenterology2014，20，1： | 1 |
| 7 | Detection Algorithm and Initial Laboratory Results Using V-BLAST Space-Time Communication Architecture 显示文摘 | Golden GD Foschini GJ Valenzuela RA Wolniansky PW | 1999 | Electronics Letters (S0013-5194)1999，35，1： | 1 |
| 8 | Broad CTL response is required to clear latentHIV-1 due to dominance of escape mutations 显示文摘 | Deng K Pertea M Rongvaux A Wang LA Ghiaur G LaiJ McHugh HL Hao HP Zhang H Margolick JB GurerC Murphy AJ Valenzuela DM Yancopoulos GD DeeksSG Strowig T Kumar PA Salzberg SL Flavell RA Siliciano RF | 2015 | Nature2015，517，7534： | 1 |
| 9 | Improving the radiological diagnosis of hepatic artery thrombosis after liver transplantation: Current approaches and future challenges显示文摘Hepatic artery thrombosis(HAT)is a devastating vascular complication following liver transplantation,requiring prompt diagnosis and rapid revascularization treatment to prevent graft loss.At present,imaging modalities such as ultrasound,computed tomography,and magnetic resonance play crucial roles in diagnosing HAT.Although imaging techniques have improved sensitivity and specificity for HAT diagnosis,they have limitations that hinder the timely diagnosis of this complication.In this sense,the emergence of artificial intelligence(AI)presents a transformative opportunity to address these diagnostic limitations.The development of machine learning algorithms and deep neural networks has demonstrated the potential to enhance the precision diagnosis of liver transplant complications,enabling quicker and more accurate detection of HAT.This article examines the current landscape of imaging diagnostic techniques for HAT and explores the emerging role of AI in addressing future challenges in the diagnosis of HAT after liver transplant. | Cristian Lindner Raúl Riquelme Rodrigo San Martín Frank Quezada Jorge Valenzuela Juan P Maureira Martín Einersen | 2024 | World Journal of Transplantation2024，14，1： | 0 |
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