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| 1 | Participation of epididymal cysteine-rich secretory proteins in sperm-egg fusion and their potential use for male fertility regulation显示文摘老鼠蛋白质 DE 是一个雄激素依赖者充满半胱氨酸的能分泌的蛋白质(松脆) 由近似附睾区域综合了。DE,也作为 CRISP-1 知道,在反应 acrosome 的精子的赤道的片断上是局部性的并且通过绑定参予配偶子熔化到鸡蛋互补地点。有 DE 的老鼠的免疫禁止富饶和精子熔化能力,建议 DE 代表一个好附睾避孕药目标。Recombinant 整理碎片和合成的肽表明 DE 经由 anevolutionarily 保存的主题的一个 12-amino 酸区域绑在卵,签名 2 (S2 ) 。松脆的其它的能力与他们的 S2 氨基酸序列被相关绑在老鼠卵。尽管阴囊的蛋白质 Tpx-1 (CRISP-2 ) 能够到啮齿类动物卵的绑定,人的附睾的 AEG 相关的蛋白质(ARP ) 和 helothermine (从蜥蜴口水) 不。S2 区域在 Tpx-1 介绍了仅仅二替换并且四在 ARPand helothermine,与 DE S2 相比,建议这氨基酸定序为鸡蛋是相关的相互作用。有 Tpx-1 和 anti-Tpx-1 的研究在卵通过绑定在配偶子熔化揭示了这蛋白质的参予到互补地点。在比赛研究, DE dose-dependently 减少了 Tpx-1 的绑定,显示那两个松脆的份额卵互补地点。当认出仅仅相应蛋白质时,那 anti-DE 和 anti-Tpx-1 禁止精子鸡蛋熔化,建议在这些之间的功能的合作相应对松脆保证授精成功。这些结果增加我们配偶子熔化的分子的机制的理解并且贡献调整方法的新、更安全的富饶的发展。 | Debora J. Cohen Vanina G. Da Ros Dolores Busso Diego A. Ellerman Julieta A. Maldera Nadia Goldweic Patricia S. Cuasnicti | 2007 | Asian Journal of Andrology2007，9，4： | 16 |
| 2 | 从附睾到卵子:CRISP蛋白在哺乳动物受精过程中的作用显示文摘哺乳动物的受精过程涉及精卵结合的很多步骤,是一个非常复杂的过程,其分了机制亟待阐明。此篇综述主要论述了CRISP(富含半胱氨酸的分泌蛋白)作为模型分子在哺乳动物受精过程中的价值。大量的体外实验和基因敲出模型研究显示,附睾内的CRISP1以两种不同的亲和力结合于精子表面,参与精子获能、精子-透明带结合、精卵融合的调控。这些研究成果可以延伸至人类。我们住研究中发现,人类具有与啮齿类同源的CRISP(hCRISP1),同样参与受精过样。CRISP家族的其他成员(睾丸内CRISP2、附挈内CRISP3—4、射精时的CRISP3)也参与了精卵结合的过程,提示同源分子间的相互协同有助于受精的成功。另外,我们的研究显示,CRISP蛋白伴随精子穿越男性及女性生殖管道的全过程。我们推测CRISP不仅参与了受精过程,而且可能成为不育和避孕研究的新靶点。 | Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone Nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D Gomez-Elias Debora J Cohen Patricia S Cuasnicu | 2015 | Asian Journal of Andrology2015，17，5： | 5 |
| 3 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 4 | Potential Use of a Poultry Manure Digestate as a Biofertiliser:Evaluation of Soil Properties and Lactuca sativa Growth显示文摘Anaerobic digestion is a process that is widely used for the treatment of organic wastes. The digestate can be used as a soil amendment or crop fertiliser. The aims of our work were to evaluate 1) the physicochemical composition and pathogen content in a digestate from poultry manure, according to international regulations, and 2) the effect of its soil application on the major chemical and biological soil properties and on the growth of Lactuca sativa. The experiment consisted of two groups of pots(with and without crop). Treatments applied to each group were as follows: low and high doses of digestate and inorganic fertiliser, and no application(control)(low dose: 70 kg nitrogen(N) ha^(-1) and 21 kg phosphorus(P) ha^(-1); high dose: 210 kg N ha^(-1) and 63 kg P ha^(-1)). Soil samples were taken 7 and 34 d(harvest) after treatment applications. Heavy metal and pathogen contents in the digestate were below the upper limit values. Despite the high pH and electrical conductivity values of the digestate, both soil parameters presented acceptable values for crop growth. Although there were no initial increases in total inorganic N and available P in soil with digestate application, an increase in the fresh weight of crop was observed with the high dose application. This is probably associated with the slow nutrient release from the digestate during the development of the crop. Changes in the microbial community were temporary and occurred at the initial sampling stage of the experiment. | Natalia MóRTOLA Romina ROMANIUK Vanina COSENTINO Maximiliano EIZA Patricia CARFAGNO Pedro RIZZO Patricia BRES Nicolás RIERA Marcos ROBA Mariano BUTTI Daiana SAINZ Lucrecia BRUTTI | 2019 | Pedosphere2019，29，1： | 2 |
| 5 | Chronic intestinal pseudo-obstruction in patients with systemic lupus erythematosus: report of four cases显示文摘 | Federico Ceccato Adrián Salas Vanina Góngora Santiago Ruta Susana Roverano Juan Carlos Marcos Mercedes Garcìa Sergio Paira | 2008 | Clinical Rheumatology2008，，3： | 2 |
| 6 | Removal of sorbed polycyclic aromatic hydrocarbons from soil,sludge and sediment samples using the Fenton's reagent process显示文摘 | VANINA F CORINE D YANN P | 2005 | Chemosphere2005，59，10： | 1 |
| 7 | A new environmentally friendly method for the production of 2,3,5-trimeth-yl-p-benzoquinone 显示文摘 | Kholdeeva O A Trukhan N N Vanina M P | 2002 | Catalysis Today2002，75，14： | 1 |
| 8 | Use of Spot-5 for mapping seagrasses:An application to Posidonia oceanic a显示文摘 | Vanina Pasqualini Christine Pergent-Martini Gerard Pergent | 2005 | Remote Sensing of Environment2005，94，： | 1 |
| 9 | Rapid determination of polycyclic aromatic hydrocarbons in sewage sludges using microwave-assisted solvent extraction: Comparison with other extraction methods显示文摘 | Vanina Flotron Justin Houessou Audrey Bosio | 2003 | Journal of Chromatography A2003，999，： | 1 |
| 10 | Magnetic resonance imaging in Posterior Reversible Encephalopathy Syndrome: report of three cases and review of literature显示文摘 | Vanina Finocchi Alessandro Bozzao Michela Bonamini Michele Ferrante Andrea Romano Claudio Colonnese Luigi Maria Fantozzi | 2005 | Archives of Gynecology and Obstetrics2005，，： | 1 |
| 11 | A new environmentally friendly method for the production of 2,3,5-trimethyl-p-benzoquinone 显示文摘 | Kholdeeva O A Trukhan N N Vanina M P | 2002 | Catalysis Today2002，75，1： | 1 |
| 12 | Environmental impact identification along the Corsican coast(Mediterranean sea)using image processing显示文摘 | Vanina Pasqualini Christine Pergent-Martini Gerard Pergent | 1999 | Aquatic Botany1999，65，14： | 1 |
| 13 | Kinetics of human cytomegalovirus (HCMV) DNAemia in transplanted patients expressed in international units as determined with the Abbott RealTi m e CMV assay and an in-house assay显示文摘 | Milena Furione Vanina Rognoni Ermanna Cabano Fausto Baldanti | 2012 | Journal of Clinical Virology2012，，4： | 1 |
| 14 | Prevalence of Insulin Resistance Syndrome in Southwestern France and Its Relationship With Inflammatory and Hemostatic Markers显示文摘 | Pedro Marques-Vidal Elizabeth Mazoyer Vanina Bongard | 2002 | Diabetes Care2002，25，： | 1 |
| 15 | Scale up of 2,4-dichlorophenol removal from aqueous solutions using Brassica napus hairy roots显示文摘 | Vanina A. Angelini Joaquín Orejas María I. Medina Elizabeth Agostini | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 16 | Effects of plasticizers and their concentrations on thermal and functional properties of gelatin - based films 显示文摘 | Vanina F M Sobrala P J A Menegalli F C | 2005 | Food Hydrocolloids2005，19，： | 1 |
| 17 | Body weight changes associated with psychopharmacology显示文摘 | PODOLSKAYA A SEDKY K | 2002 | Psychiatr Serv2002，53，： | 1 |
| 18 | Co-containing polyoxometalate-based heterogeneous catalysts for the selective aerobic oxidation of aldehydes under ambient conditions显示文摘 | Vanina M P Timofeeva M N | 2004 | J Catal2004，226，2： | 1 |
| 19 | High consumptions of grain, fish, dairy produets and combinations of these are associated with a low prevalence of metabolie syndrome显示文摘 | Jean-BR Vanina B Jean D | 2007 | J Epidemiol Community Health2007，61，9： | 1 |
| 20 | Impact of contaminated-sediment resuspension on phytoplankton in the Biguglia lagoon (Corsica, Mediterranean Sea)显示文摘 | Céline Lafabrie Marie Garrido Christophe Leboulanger Philippe Cecchi Gérald Grégori Vanina Pasqualini Olivier Pringault | 2013 | Estuarine Coastal and Shelf Science2013，，： | 1 |
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