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| 1 | Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation显示文摘The intimate connection and the strict mutual cooperation between the gut and the liver realizes a functional entity called gut-liver axis.The integrity of intestinal barrier is crucial for the maintenance of liver homeostasis.In this mutual relationship,the liver acts as a second firewall towards potentially harmful substances translocated from the gut,and is,in turn,is implicated in the regulation of the barrier.Increasing evidence has highlighted the relevance of increased intestinal permeability and consequent bacterial translocation in the development of liver damage.In particular,in patients with non-alcoholic fatty liver disease recent hypotheses are considering intestinal permeability impairment,diet and gut dysbiosis as the primary pathogenic trigger.In advanced liver disease,intestinal permeability is enhanced by portal hypertension.The clinical consequence is an increased bacterial translocation that further worsens liver damage.Furthermore,this pathogenic mechanism is implicated in most of liver cirrhosis complications,such as spontaneous bacterial peritonitis,hepatorenal syndrome,portal vein thrombosis,hepatic encephalopathy,and hepatocellular carcinoma.After liver transplantation,the decrease in portal pressure should determine beneficial effects on the gut-liver axis,although are incompletely understood data on the modifications of the intestinal permeability and gut microbiota composition are still lacking.How the modulation of the intestinal permeability could prevent the initiation and progression of liver disease is still an uncovered area,which deserves further attention. | Alberto Nicoletti Francesca Romana Ponziani Marco Biolato Venanzio Valenza Giuseppe Marrone Gabriele Sganga Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，33： | 19 |
| 2 | Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease显示文摘BACKGROUND In non-alcoholic fatty liver disease(NAFLD), a high-fat or high-fructose diet increases intestinal permeability and promotes derangement of the gut-liver axis.We hypothesize that, diet could be able to modulate intestinal permeability in patients with NAFLD.AIM To detect diet-induced modification of intestinal permeability in patients with NAFLD undergoing a Mediterranean diet or a low-fat diet.METHODS The current study was a dietary intervention for non-diabetic, patients with biopsy-verified NAFLD and increased transaminases. A crossover design was employed: participants underwent 16 weeks of Mediterranean diet, 16 wk of free wash-out, and 16 weeks of low-fat diet. Both diets were hypocaloric and no consumption of supplements was allowed. All patients were followed bimonthly by a dietitian. Evaluations of clinical and metabolic parameters were completed at baseline and at the end of each dietary period. Intestinal permeability was assessed by chromium-51 ethylene diamine tetraacetate excretion testing(51 CrEDTA).RESULTS Twenty Caucasian patients, 90% male, median age 43 years, body mass index(BMI) 30.9, with biopsy-verified NAFLD were enrolled. At the end of 16 weeks of a Mediterranean diet, a significant reduction in mean body weight(-5.3 ± 4.1 kg,P = 0.003), mean waist circumference(-7.9 ± 4.9 cm, P = 0.001), and mean transaminase levels [alanine aminotransferase(ALT)-28.3 ± 11.9 IU/L, P =0.0001; aspartate aminotransferase(AST)-6.4 ± 56.3 IU/L, P = 0.01] were observed. These benefits were maintained after 16 wk of wash-out and also after16 wk of low-fat diet, without further improvements. Fourteen of the 20 patients had intestinal permeability alteration at baseline(mean percentage retention of51 Cr-EDTA = 5.4%), but no significant changes in intestinal permeability were observed at the end of the 16 wk of the Mediterranean diet or 16 wk of the low-fat diet.CONCLUSION Mediterranean diet is an effective strategy for treating overweight, visceral obesity and serum transaminase in patients with NAFLD. If the Mediterranean diet can improve intestinal permeability in patients with NAFLD, it deserves further investigation. | Marco Biolato Fiorella Manca Giuseppe Marrone Consuelo Cefalo Simona Racco Giacinto A Miggiano Venanzio Valenza Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 3 | Early radiological assessment of locally advanced pancreatic cancer treated with electrochemotherapy显示文摘AIM To report early imaging assessment of ablated area post electrochemotherapy(ECT) in patients with locally advanced pancreatic cancer(LAPC). METHODS ECT was performed in 19 LAPC patients enrolled in an approved ongoing clinical phase Ⅰ/Ⅱ study. Before and after ECT, 18 patients underwent computed tomography(CT) scan, 11 patients underwent morphological and functional magnetic resonance(MR) scan(dynamic contrast enhanced-MRI) calculating wash-in slope(WIS) and wash-out slope(WOS); diffusion weighted imaging calculating pseudo-diffusivity(Dp), perfusion fraction(fp) and tissue diffusivity(Dt); 10 patients underwentpositron emission tomography(PET). Response evaluation criteria in solid tumour(RECIST) on MR and CT were used to assess tumour therapy response. Choi on CT, PET response criteria in solid tumors(PERCIST) on PET and functional parameters on MR were used to evaluate treatment response.RESULTS For each patient no significant reduction was measurable by CT and MR using RECIST. According Choi criteria a partial response was obtained in 18/18(100.0%) patients. According PERCIST criteria 6/10(60.0%) patients showed a partial response, 3/10(30.0%) stable disease and 1/10(10.0%) progression disease. Moreover, using functional MR parameters, a significant reduction of viable tumour after ECT can be observed. According ΔWIS and ΔWOS 9/11(81.8%) patients exhibited a partial response and 2/11(18.2%) stable disease; 8/11(72.7%) patients were considered in partial response by ΔDp evaluation and 3/11(27.3%) in stable disease; according ΔDt 7/11(63.6%) patients showed a partial response, 1/11(9.1%) showed progression of disease and 3/11(27.3%) were stable. Perfusion fraction fp showed a significant reduction after ECT only in four patients. No significant difference was observed after ECT in signal intensity of T1-weighted images and T2-weighted images, and in equilibrium-phase of contrast study, according to χ2 test was observed. A good correlation was reported between ΔHounsfield unit and Δmaximum standardized uptake value and between Δfp and ΔWOS, with a significant statistically difference(P < 0.05) using Spearman correlation coefficient.CONCLUSION Perfusion and diffusion MR derived parameters, Choi, PERCIST criteria are more performant than morphological MR and CT criteria to assess ECT treatment response. | Vincenza Granata Roberta Fusco Sergio Venanzio Setola Mauro Piccirillo Maddalena Leongito Raffaele Palaia Francesco Granata Secondo Lastoria Francesco Izzo Antonella Petrillo | 2017 | World Journal of Gastroenterology2017，23，26： | 3 |
| 4 | Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease显示文摘 | Luca Miele Venanzio Valenza Giuseppe La Torre Massimo Montalto Giovanni Cammarota Riccardo Ricci Roberta Mascianà Alessandra Forgione Maria L. Gabrieli Germano Perotti Fabio M. Vecchio Gianlodovico Rapaccini Giovanni Gasbarrini Chris P. Day Antonio Grieco | 2009 | Hepatology2009，，6： | 2 |
| 5 | Imaging of peritoneal carcinomatosis with FDG PET-CT: diagnostic patterns, case examples and pitfalls显示文摘 | Anna Maria Gaetano Maria Lucia Calcagni Vittoria Rufini Venanzio Valenza Alessandro Giordano Lorenzo Bonomo | 2009 | Abdominal Imaging2009，，3： | 1 |
| 6 | Influence of temperature on microdomain organization of mixed cationic-zwittcrionic lipidic monolayers at the air-water interface显示文摘 | Bordi F Cametti C Venanzio C D | | 0，，： | 1 |
| 7 | Influence of temperature on microdomain organization of mixed cationic- zwitterionielipidic monolayers at the air- water interface 显示文摘 | BordiF CamettiC Venanzio C I) SennatoS Zuzzi S | 2008 | Colloids Surf B Bioniterface2008，61，30： | 1 |
| 8 | Oropharyngoesophageal scintigraphy in the diagnostic algorithm of laryngopharyngeal reflux disease: A useful exam?显示文摘 | Jacopo Galli Mariangela Volante Claudio Parrilla Mario Rigante Venanzio Valenza | 2005 | Otolaryngology - Head and Neck Surgery2005，，5： | 1 |
| 9 | Endothelial Function and Common Carotid Artery Wall Thickening in Patients With Essential Hypertension显示文摘 | Lorenzo Ghiadoni Stefano Taddei Agostino Virdis Isabella Sudano Virgilio Di Legge Mario Meola Lorenzo Di Venanzio Antonio Salvetti | 1998 | Hypertension1998，，1： | 1 |
| 10 | Efficient Monte Carlo technique for locating critical slip surface 显示文摘 | Venanzio R G | 1996 | Journal of Geotechnical Engineering1996，122，7： | 1 |
| 11 | Efficient Monte Carlo technique for locating critical slip surface 显示文摘 | Venanzio R Greco | 1996 | Journal of Geotechnical Engineering1996，122，7： | 1 |
| 12 | Discussion of“active earth pressure on retaining wall for c-soil backfill under seismic loading condition”显示文摘 | VENANZIO R GRECO | 2010 | Journal of Geotechnical and Geoenviron-mental Engineering2010，136，： | 1 |
| 13 | Increased Intestinal Permeability and Tight JunctionAlterations in Nonalcoholic Fatty Liver Disease显示文摘 | Luca Miele Venanzio Valenza | | Hepatology0，，： | 1 |
| 14 | Sur gicalProphylaxis of Pouchitis in Ulcerative Colitis显示文摘 | Giuseppe Brisinda Serafino Vanella Venanzio Valenza etal | 2011 | Di gestive Diseasesand Sciences (0 163-2 116) Volume 56 Issue 52011，2011，： | 1 |
| 15 | 干旱区机械化集雨整地造林效果分析——“瓦勒拉尼系统”集雨造林效果研究显示文摘从2006年到2009年,中国国家林业局与意大利环境国土海洋部合作,应用意大利机械化集雨抗旱整地造林技术——'瓦勒拉尼系统'在内蒙古赤峰市进行造林试验示范。与传统的人工整地造林相比,降水利用率提高两倍,土壤紧实度降低82%,土壤含水率平均提高60%,造林成活率提高30%左右。对'瓦勒拉尼系统'整地造林各项技术参数的测试分析表明,该系统具有深耕集雨、快速高效、经济实用、适应性强等特点。该系统在集雨抗旱造林方面具有的优越性和先进性,为该系统在中国干旱区推广应用提供了科学依据和实用技术方法。 | 王君厚 董建林 李忠平 赵中南 赵有贤 赵国君 王树元 王永民 林景友 庞秀谦 Venanzio Vallerani Alessandro Vallerani | 2011 | 中国沙漠2011，31，5： | 0 |
| 16 | 确定临界滑动面的蒙特卡洛有效方法显示文摘搜索斜坡稳定性分析的临界滑动面是由安全系数的极小化来完成的。非线性规化确定的方法是非常广泛使用的方法,由于考虑到随机搜索效能低而被忽视。本文介绍了确定临界滑动面的蒙特卡洛(Monte Carlo)有效方法。每一新的滑动面由适当的方法随机产生,此方法能依次对每阶段作出明确的表达。据分析比较,提供的方法所得到解的精确度与最好的非线性规划法相同。所提供的方法构造简单,并容易程序化、积分及特殊需要的修正。 | Venanzio R.Greco 赵之华 | 1997 | 路基工程1997，，3： | 0 |
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