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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Generation of DNA profiles from fabrics without DNA extraction 显示文摘 | Adrian L Vera P Yuvaneswari C S | 2010 | Forensic Sci Int(Genetics)2010，4，： | 1 |
| 3 | Pt/SO2- -ZrO2 catalysts prepared from Pt organometallic compounds 显示文摘 | VERA C R PIECK C L SHIMIZU K | 2002 | Applied Catalysis A: General2002，232，12： | 1 |
| 4 | Effects of virtual reality immersion and audiovisual distraction techniques for patients with pruritus显示文摘 | Vera L Florella M Sarale C et a1 | 2009 | Pain Res Manag2009，14，4： | 1 |
| 5 | Characteris-tics of Hemocompatible Ti02 Nano- films Produced by theSol-gel and Anodic Oxidation Techniques 显示文摘 | Schvezov C E Alterach M A Vera M L | 2010 | Jom2010，62，6： | 1 |
| 6 | Insulin-like growth factor-I cDNA cloning, gene expression and potential use as a growth rate indicator in Nile tilapia, Oreochromis niloticus 显示文摘 | Vera Cruz E M Brown C L Adam Luckenbach J | 2006 | Aquaculture2006，251，： | 1 |
| 7 | Performance estimation vis -f -vis design of mixed -feed lime shaft kiln 显示文摘 | Vera C L Dave N G Saraf S K | 1988 | Zement - Kalk -Gips1988，9，： | 1 |
| 8 | Inhibition of macrophage migration inhibitory factor decreases proliferation and cytokine expression in bladder cancer cells 显示文摘 | Meyer-Siegler K L Leitheit E C Vera P L | 2004 | BMC Cancer2004，4，： | 1 |
| 9 | Degradation of tomato pathogenesis-elated proteins by an endogenous 37-kDa aspar- tyl endoproteinase 显示文摘 | Rodrigo I Vera P Van Loon L C | 1989 | European Journal of Biochemistry1989，184，： | 1 |
| 10 | Recent advances in BNF with non-Iegume plants 显示文摘 | Baldani J I Vera L C Baldani L D | 1997 | Soil Biol Biochem1997，29，5： | 1 |
| 11 | Degradation of tobac- co pathogenesis-related proteins: Evidence for conserved mecha- nisms of degradation of pathogenesis-related proteins in plants 显示文摘 | Rodrigo I Vera P Van Loon L C | 1991 | Plant Physiology1991，95，2： | 1 |
| 12 | Inheritance of seed coat color in Brassicajuncea 显示文摘 | Vera C L Woods D L Downey R K | 1979 | Can J Plant Sci1979，59，： | 1 |
| 13 | New sensitive layers for surface acoustic wave gas sensors based on polymer and carbon nanotube composites显示文摘 | Sayago I Fern ndez M J Fontecha J L Horrillo M C Vera C Obieta I Bustero I | 2012 | Sensors and Actuators B:Chemical2012，175，： | 1 |
| 14 | Effect of Water Vapor on the Activity of Pt-Pd/Al2O3 Catalysts for Methane Cobustion显示文摘 | Pieck C L Vera C R Peirotti E M | 2002 | Applied Catalysis A:General2002，226，： | 1 |
| 15 | A report on the outbreak of Zika virus on Easter Island,South Pacific,2014显示文摘 | Tognarelli J Ulloa S Villagra E Lagos J Aguayo C Fasce R Parra B Mora J Becerra N Lagos N Vera L Olivares B Vilches M Fernández J | 2015 | Arch Virol2015，，： | 1 |
| 16 | Isolation of independent gene pairs at two loci for seed coat colour in Brassica juncea 显示文摘 | Vera C L Woods D L | 1982 | Ca- nadian Journal of Plant Science1982，62，1： | 1 |
| 17 | Isolation of independent gene pairs at two loci for seed coat color in Brassica juncea 显示文摘 | Vera C L Woods D L | 1982 | Can J Plant Sci1982，62，： | 1 |
| 18 | Serum cystatin C as a new marker for noninvasive estimation of glomerularfiltration rate and as a marker for early renal impairment显示文摘 | Coll E Botey A Alvarez L Poch E Quinto L Saurina A Vera M Piera C Darnell A | 2000 | Am J Kidney Dis2000，36，1： | 1 |
| 19 | Effects of virtual reality immersion and audiovisual distract-ion techniques for patients with pruritus显示文摘 | Vera L Florella M Sarale C | 2009 | Pain Res Manag2009，14，4： | 1 |
| 20 | Studies on the interaction of emeraldine base polyaniline with Cu(Ⅱ), Fe(Ⅲ), and Zn(Ⅱ) ions in solutions and films显示文摘 | Celly M S I Ana M D C F Vera R L C | 2007 | Macromolecules2007，40，： | 1 |
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