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| 1 | IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis显示文摘AIM To investigate the association of seven single nucleotide polymorphisms(SNPs) of the IL23 R gene with the clinical picture of ulcerative colitis(UC). METHODS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNPs of IL23 R gene(rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).RESULTS Four out of seven analyzed SNPs had statistically significant influence on the clinical picture of UC. Two SNPs were associated with greater colonic extension(rs2201841 P = 0.0084; rs10489629 P = 0.0405). For two of the SNPs, there was more frequently need for operations (rs2201841 P = 0.0348, OR = 8.0; rs10889677 P = 0.0347, OR = 8.0). The rs2201841 showed to be a risk factor for the development of iron deficiency (P = 0.0388, OR = 6.1837). For patients with the rs10889677, a therapy with azathioprine was more frequently necessary(P = 0.0116, OR = 6.1707). Patients with rs10489629 SNP had a lower risk for weight loss(P = 0.0169, OR = 0.3394). Carriers of the heterozygous variant had a higher risk for an extended disease (P = 0.0284). The rs7517847 showed a protective character leading to mild bowel movements. Three SNPs demonstrated no statistically significant influence on any examined clinical features of UC.CONCLUSION We demonstrated susceptible or protective character of the investigated IL23 R SNPs on the phenotype of UC, confirming the genetic association. | Sarah Fischer Erzsébet Kovesdi Lili Magyari Veronika Csongei Kinga Hadzsiev Béla Melegh Péter Hegyi Patrícia Sarlós | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 2 | Lipotoxicity in the liver显示文摘Obesity due to excessive food intake and the lack of physical activity is becoming one of the most serious public health problems of the 21stcentury. With the increasing prevalence of obesity, non-alcoholic fatty liver disease is also emerging as a pandemic. While previously this pathophysiological condition was mainly attributed to triglyceride accumulation in hepatocytes,recent data show that the development of oxidative stress, lipid peroxidation, cell death, inflammation and fibrosis are mostly due to accumulation of fatty acids,and the altered composition of membrane phospholipids. In fact, triglyceride accumulation might play a protective role, and the higher toxicity of saturated or trans fatty acids seems to be the consequence of a blockade in triglyceride synthesis. Increased membrane saturation can profoundly disturb cellular homeostasis by impairing the function of membrane receptors,channels and transporters. However, it also inducesendoplasmic reticulum stress via novel sensing mechanisms of the organelle's stress receptors. The triggered signaling pathways in turn largely contribute to the development of insulin resistance and apoptosis. These findings have substantiated the lipotoxic liver injury hypothesis for the pathomechanism of hepatosteatosis.This minireview focuses on the metabolic and redox aspects of lipotoxicity and lipoapoptosis, with special regards on the involvement of endoplasmic reticulum stress responses. | Veronika Zámbó Laura Simon-Szabó Péter Szelényi va Kereszturi Gábor Bánhegyi Miklós Csala | 2013 | World Journal of Hepatology2013，5，10： | 3 |
| 3 | Variceal bleeding in portal hypertension: bacterial infection and comparison of efficacy of intravenous and per-oral application of antibiotics – a randomized trial显示文摘 | Jan Lata Jana Juránková Libu?e Husová Michal ?enky?ík Petr Dítě Milan Dastych Veronika P?íbramská Radek Kroupa | 2005 | European Journal of Gastroenterology & Hepatology2005，，10： | 1 |
| 4 | Instant Convolution Shadows for Volumetric Detail Mapping显示文摘 | Daniel P Veronika Jan M | 2013 | ACM Transactions on Graphics2013，32，5： | 1 |
| 5 | Ultrathin layer-by-layer hydrogels with incorporated gold nanorods as pH-sensitive optical materials显示文摘 | Veronika Kozlovskaya Eugenia Kharlampieva Bishnu P Khanal | 2008 | Chem Mater2008，20，24： | 1 |
| 6 | Proteomic investigation of wheat intercellular washing fluid显示文摘 | VERONIKA P KRISZTIN H LKOS M | 2005 | Acta Biological Szegediensis2005，49，12： | 1 |
| 7 | Revisiting the mechanism of the auto-activation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r 显示文摘 | Jozsef K Veronika H Anna P | 2008 | Mol Immunol2008，45，： | 1 |
| 8 | Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test显示文摘 | VERONIKA B FRANK P HILKE W | 1998 | Planta Medica1998，64，4： | 1 |
| 9 | Disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells in non-human primates显示文摘BACKGROUND The development of regenerative therapy for human spinal cord injury(SCI)is dramatically restricted by two main challenges:the need for a safe source of functionally active and reproducible neural stem cells and the need of adequate animal models for preclinical testing.Direct reprogramming of somatic cells into neuronal and glial precursors might be a promising solution to the first challenge.The use of non-human primates for preclinical studies exploring new treatment paradigms in SCI results in data with more translational relevance to human SCI.AIM To investigate the safety and efficacy of intraspinal transplantation of directly reprogrammed neural precursor cells(drNPCs).METHODS Seven non-human primates with verified complete thoracic SCI were divided into two groups:drNPC group(n=4)was subjected to intraspinal transplantation of 5 million drNPCs rostral and caudal to the lesion site 2 wk post injury,and lesion control(n=3)was injected identically with the equivalent volume of vehicle.RESULTS Follow-up for 12 wk revealed that animals in the drNPC group demonstrated a significant recovery of the paralyzed hindlimb as well as recovery of somatosensory evoked potential and motor evoked potential of injured pathways.Magnetic resonance diffusion tensor imaging data confirmed the intraspinal transplantation of drNPCs did not adversely affect the morphology of the central nervous system or cerebrospinal fluid circulation.Subsequent immunohistochemical analysis showed that drNPCs maintained SOX2 expression characteristic of multipotency in the transplanted spinal cord for at least 12 wk,migrating to areas of axon growth cones.CONCLUSION Our data demonstrated that drNPC transplantation was safe and contributed to improvement of spinal cord function after acute SCI,based on neurological status assessment and neurophysiological recovery within 12 wk after transplantation.The functional improvement described was not associated with neuronal differentiation of the allogeneic drNPCs.Instead,directed drNPCs migration to the areas of active growth cone formation may provide exosome and paracrine trophic support,thereby further supporting the regeneration processes. | Vladimir P Baklaushev Oleg V Durov Vladimir A Kalsin Eugene V Gulaev Sergey V Kim Ilya L Gubskiy Veronika A Revkova Ekaterina M Samoilova Pavel A Melnikov Dzhina D Karal-Ogly Sergey V Orlov Alexander V Troitskiy Vladimir P Chekhonin Alexander V Averyanov Jan-Eric Ahlfors | 2021 | World Journal of Stem Cells2021，13，5： | 1 |
| 10 | Ornamental fish as a source of plasmid-mediated quinolone resistance genes and antibiotic resistance plamids显示文摘 | Hana D Iva K Veronika P | 2014 | Veterinary Microbiology2014，171，34： | 1 |
| 11 | Canine distemper virus and measles virus fusion glycoprotein timers: partial membrane-proximal ectodomain cleavage enhances function 显示文摘 | Veronika VM D Milosivic P Devaux | 2004 | Journal of Virology2004，78，15： | 1 |
| 12 | Revisiting the mechanism of the auto-activation of the complement protease Clr in the C1 complex:Structure of the active catalytic region of Clr显示文摘 | Jozsef K Veronika H Anna P | 2008 | Mol Immunol2008，45，6： | 1 |
| 13 | C alleles on IBD5 locus of chromosome 5q31 region confer risk for Crohn’s disease in Hungarian patients显示文摘 | Lilla Lakner Veronika Cs?ngei Patrícia Sarlós Luca Járomi Enik? Sáfrány Márta Varga Péter Orosz Lili Magyari Judit Bene Pál Miheller Zsolt Tulassay Béla Melegh | 2009 | International Journal of Colorectal Disease2009，，5： | 1 |
| 14 | Antisence oligonucleotide experiments elucidate the essential role of TITIN in sarcomerogenesis in adult rat cardiomyocytes in long-term culture显示文摘 | Veronika P Sawa K Keisuke S | 2000 | J Cell Science2000，113，21： | 1 |
| 15 | Polo-like kinase1(Plk1)as a novel drug target in chronic myeloid leukemia:overriding imatinib resistance with the Plk1 inhibitor BI2536显示文摘 | Karoline VG Veronika F Barbara P | 2010 | Cancer Res2010，70，4： | 1 |
| 16 | Effects of Particle Size,Heating Rate and Pressure on Measurement of Pyrolysis Kinetics by Thermogravimetric Analysis显示文摘 | Veronika S Josef P Gernot S | | 0，，3： | 1 |
| 17 | Effect of particle size heating rate and pressure on measurement of pyrolysis ki- netics by thermogravimentric analysis显示文摘 | VERONIKA S JOSEF P GERNOT S | 1997 | Fuel1997，76，3： | 1 |
| 18 | Using a mobile health application to support self-management in COPD:a qualitative study显示文摘 | Veronika W Jonathan P Maxine H | 2014 | Br J Gen Pract2014，64，624： | 1 |
| 19 | Combined Exposure of Japanese Quails to Cyanotoxins, Newcastle Virus and Lead: Oxidative Stress Responses 显示文摘 | VERONIKA P HANA P JIRI P | 2011 | Ecotoxicol Environ Saf2011，74，7： | 1 |
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