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| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 2 | Circular dichroism and guanine quadmplexes显示文摘 | Michaela V Iva K Janos S | 2012 | Methods2012，57，1： | 1 |
| 3 | Analysis of relative gene expression datausing real-time quantitative PCR and the 2-△△Ct method显示文摘 | L IVA K K Schmittgen T | 2001 | Methods2001，25，： | 1 |
| 4 | Analyte and system eigenpeaks in nonaqueous capillary zone electrophoresis: theoretical description and experimental confirmation with methanol as solvent.显示文摘 | Vcelakova K Iva Zuskova I Porras S P Gas B.Kenndler E | | 0，，： | 1 |
| 5 | Effect of Deposition Parameters on Microstructure of Electrodeposited Nickel Thin films 显示文摘 | MISHRA Amaresh Chandra THAKUR Awalendra K SRIN- IVAS V | 2009 | J Mater Sci2009，44，： | 1 |
| 6 | Jaggedl-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin显示文摘 | Kevin GL Kyle N Iva K | 2007 | J Exp Med2007，204，： | 1 |
| 7 | Ornamental fish as a source of plasmid-mediated quinolone resistance genes and antibiotic resistance plamids显示文摘 | Hana D Iva K Veronika P | 2014 | Veterinary Microbiology2014，171，34： | 1 |
| 8 | Effects of bovine spermatozoa preparation on embryonic developmentin vitro显示文摘 | Marko S Martina K Iva G Z | 2006 | Reprod Biol Endocrinol2006，58，4： | 1 |
| 9 | Jaggedl-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin 显示文摘 | Kevin G L Kyle N Iva K | 2007 | J Exp Med2007，204，12： | 1 |
| 10 | Synthesis andhigh-temperrature stability of titanium aluminize matrix in situcomposites 显示文摘 | Tsunekawa Y Gotoh K Okum iva M | 1998 | Journal of Thermal Spray Technology1998，1，3： | 1 |
| 11 | Celiac disease markers in patients with liver diseases: A single center large scale screening study显示文摘AIM:To study the coincidence of celiac disease, we tested its serological markers in patients with various liver diseases.METHODS:Large-scale screening of serum antibodies against tissue transglutaminase (tTG), and deamidated gliadin using enzyme-linked immunosorbent assay and serum antibodies against endomysium using immunohistochemistry, in patients with various liver diseases (n = 962) and patients who underwent liver transplantation (OLTx, n = 523) was performed. The expression of tTG in liver tissue samples of patients simultaneously suffering from celiac disease and from various liver diseases using immunohistochemistry was carried out. The final diagnosis of celiac disease was confirmed by histological analysis of small-intestinal biopsy. RESULTS:We found that 29 of 962 patients (3%) with liver diseases and 5 of 523 patients (0.8%) who underwent OLTx were seropositive for IgA and IgG anti-tTG antibodies. However, celiac disease was biopsy-diagnosed in 16 patients:4 with autoimmune hepatitis type Ⅰ, 3 with Wilson's disease, 3 with celiac hepatitis, 2 with primary sclerosing cholangitis, 1 with primary biliary cirrhosis, 1 with Budd-Chiari syndrome, 1 with toxic hepatitis, and 1 with non-alcoholic steatohepatitis. Unexpectedly, the highest prevalence of celiac disease was found in patients with Wilson's disease (9.7%), with which it is only rarely associated. On the other hand, no OLTx patients were diagnosed with celiac disease in our study. A pilot study of the expression of tTG in liver tissue using immunohistochemistry documented the overexpression of this molecule in endothelial cells and periportal hepatocytes of patients simultaneously suffering from celiac disease and toxic hepatitis, primary sclerosing cholangitis or autoimmune hepatitis type Ⅰ. CONCLUSION:We suggest that screening for celiac disease may be beneficial not only in patients with associated liver diseases, but also in patients with Wilson's disease. | Pavel Drastich Eva Honsová Alena Lodererová Marcela Jaresová Aneta Pekáriková Iva Hoffmanová Ludmila Tuková Helena Tlaskalová-Hogenová Julius piák Daniel Sánchez | 2012 | World Journal of Gastroenterology2012，18，43： | 0 |
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