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| 1 | Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease显示文摘Mitochondrial dysfunction is known to be a contributing factor to a number of diseases including chronic alcohol induced liver injury. While there is a detailed understanding of the metabolic pathways and proteins of the liver mitochondrion, little is known regarding how changes in the mitochondrial proteome may contribute to the development of hepatic pathologies. Emerging evidence indicates that reactive oxygen and nitrogen species disrupt mitochondrial function through post-translational modifications to the mitochondrial proteome. Indeed, various new affinity labeling reagents are available to test the hypothesis that post-translational modification of proteins by reactive species contributes to mitochondrial dysfunction and alcoholic fatty liver disease. Specialized proteomic techniques are also now available, which allow for identification of defects in the assembly of multi-protein complexes in mitochondria and the resolution of the highly hydrophobic proteins of the inner membrane. In this review knowledge gained from the study of changes to the mitochondrial proteome in alcoholic hepatotoxicity will be described and placed into a mechanistic framework to increase understanding of the role of mitochondrial dysfunction in liver disease. | Sudheer K Mantena Adrienne L King Kelly K Andringa Aimee Landar Victor Darley-Usmar Shannon M Bailey | 2007 | World Journal of Gastroenterology2007，13，37： | 7 |
| 2 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Christopher J L Murray Theo Vos Rafael Lozano Mohsen Naghavi Abraham D Flaxman Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 3 | A Stable Motion Control System for Manipulator via Fuzzy Self-tuning显示文摘 | Miguel A L Rafael K Victor S | 2001 | Fuzzy Sets and System2001，124，2： | 1 |
| 4 | Constructed wetlands for livestock wastewater management显示文摘 | Robert L K Victor W E Robert E B | 2000 | Ecological Engineering2000，15，12： | 1 |
| 5 | A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy:results of a randomized,controlled,multicenter trial显示文摘 | Rainer F Victor L Thomas K | 2013 | Cancer2013，119，18： | 1 |
| 6 | Myogenin,a factor regulating myogenesis,has a domain homologous to MyoD显示文摘 | Woodering E W David A S Victor K L | 1989 | Cell1989，56，4： | 1 |
| 7 | Modular Product Design with Grouping Genetic Algorithm: A Case Study Computers and Industrial Engineering Archive显示文摘 | Victor B K Tseng P L | 2004 | Computers and Industrial Engineering2004，46，3： | 1 |
| 8 | Thomas, Post-Earning-Announcement Drift:delayed price response or risk premium显示文摘 | Bernard Victor L Jacob K | 1989 | Journal of Accounting Research1989，，27： | 1 |
| 9 | Chemical-Reaction-ln- spired Metahearistic for Optimization 显示文摘 | Albert Y S Victor O K L | 2010 | IEEE Trans on Evolutionary Computation2010，14，3： | 1 |
| 10 | Kinetics of the acid decomposition of sodium thiosulfate in dilute solutions显示文摘 | Dinegar R H Semellie R H Victor K L M 1991 | 1991 | J Am Chem Soc1991，73，： | 1 |
| 11 | Transmission Range Control in Multihop Packet Radio Networks 显示文摘 | Hou Ting-chao Victor O K L | 1986 | IEEE Transactions on Communications1986，34，1： | 1 |
| 12 | Development of a systematic method for intelligent compaction analysis and mangement显示文摘 | Xu Qin - wu George K Victor L | 2012 | Construction and Building Materials2012，37，： | 1 |
| 13 | Southern astrophysical research (SOAR) telescope steps on the route tosuccess显示文摘 | Thomas A S Victor L K Stephen R H | 2003 | SPIE2003，4837，： | 1 |
| 14 | Theory, production and mechanism of formation of rnonodispersed hydrosols显示文摘 | Victor K L Robert H D | 1950 | Journal of the American Chemical Society1950，72，11： | 1 |
| 15 | Down syndrome-recent progress and future prospects显示文摘 | Frances K Wiseman Kate A Alford Victor L J | 2009 | Human Molecular Genetics2009，18，： | 1 |
| 16 | Influences of intelligent compaction uniformity on pavement performances of hot mix asphalt显示文摘 | XU Qinwu George K C Victor L G | 2012 | Construction and Building Materials2012，30，： | 1 |
| 17 | An intelligent supplier management tool for benchmarking suppliers in outsource manufacturing显示文摘 | Choy K L Lee W B Victor Lo | 2002 | Expert Systems with Applications2002，，22： | 1 |
| 18 | Anisotropic elastoplastic bounding surface model for cohesive soils显示文摘 | HOE I L YUE D Y VICTOR N K | 2002 | Journal of Engineering Mechanics ASCE2002，128，7： | 1 |
| 19 | Endothelin-1 overexpression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet显示文摘 | Amy C Y Lo Ann Y S Chen Victor K L Hung | | 0，，08： | 1 |
| 20 | Molecular structures of gas-phase polyatomic molecules determined by spectroscopic methods 显示文摘 | Marlin D H Victor W L Robert L K | 1979 | Journal of Physical and Chemical Reference Data1979，8，3： | 1 |
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