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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | Assessment of liver ablation using cone beam computed tomography显示文摘AIM: To investigate the feasibility and accuracy of cone beam computed tomography(CBCT) in assessing the ablation zone after liver tumor ablation.METHODS: Twenty-three patients(17 men and 6 women, range: 45-85 years old, mean age 65 years) with malignant liver tumors underwent ultrasoundguided percutaneous tumor ablation [radiofrequency(n = 14), microwave(n = 9)] followed by intravenous contrast-enhanced CBCT. Baseline multidetector computed tomography(MDCT) and peri-procedural CBCT images were compared. CBCT image quality was assessed as poor, good, or excellent. Image fusion was performed to assess tumor coverage, and quality of fusion was rated as bad, good, or excellent. Ablation zone volumes on peri-procedural CBCT and post-procedural MDCT were compared using the nonparametric paired Wilcoxon t-test.RESULTS: Rate of primary ablation effectiveness was 100%. There were no complications related to ablation. Local tumor recurrence and new liver tumors were found 3 mo after initial treatment in one patient(4%). The ablation zone was identified in 21/23(91.3%) patients on CBCT. The fusion of baseline MDCT and peri-procedural CBCT images was feasible in all patients and showed satisfactory tumor coverage(at least 5-mm margin). CBCT image quality was poor, good, and excellent in 2(9%), 8(35%), and 13(56%), patients respectively. Registration quality between periprocedural CBCT and post-procedural MDCT images was good to excellent in 17/23(74%) patients. The median ablation volume on peri-procedural CBCT and post-procedural MDCT was 30 cm3(range: 4-95 cm3) and 30 cm3(range: 4-124 cm3), respectively(P-value > 0.2). There was a good correlation(r = 0.79) between the volumes of the two techniques. CONCLUSION: Contrast-enhanced CBCT after tumor ablation of the liver allows early assessment of the ablation zone. | Mohamed Abdel-Rehim Maxime Ronot Annie Sibert Valérie Vilgrain | 2015 | World Journal of Gastroenterology2015，21，2： | 6 |
| 3 | Right Portal Vein Ligation is as Efficient as Portal Vein Embolization to Induce Hypertrophy of the Left Liver Remnant显示文摘 | B. Aussilhou M. Lesurtel A. Sauvanet O. Farges S. Dokmak N. Goasguen A. Sibert V. Vilgrain J. Belghiti | 2008 | Journal of Gastrointestinal Surgery2008，，2： | 2 |
| 4 | Focal nodular hyperplasia显示文摘 | Valérie Vilgrain | 2005 | European Journal of Radiology2005，，2： | 2 |
| 5 | Portal Vein Embolization Before Right Hepatectomy: Prospective Clinical Trial显示文摘 | Olivier Farges Jacques Belghiti Reza Kianmanesh Jean Marc Regimbeau Roberto Santoro Valérie Vilgrain Alban Denys Alain Sauvanet | 2003 | Annals of Surgery2003，，2： | 2 |
| 6 | Apparent diffusion coefficient from magnetic resonance imaging as a biomarker in oncology drug development显示文摘 | Ralph Sinkus Bernard E. Van Beers Valérie Vilgrain Nandita DeSouza John C. Waterton | 2011 | European Journal of Cancer2011，，4： | 2 |
| 7 | Predictive factors for failure of pelvic arterial embolization for postpartum hemorrhage显示文摘 | Olivier Poujade Magaly Zappa Irène Letendre Pierre F. Ceccaldi Valérie Vilgrain Dominique Luton | 2012 | International Journal of Gynecology and Obstetrics2012，，2： | 2 |
| 8 | Angiogenesis:the VE-cadherinswitch显示文摘 | Wallez Y Vilgrain I Huber P | 2006 | Trends Cardiovasc Med2006，16，2： | 1 |
| 9 | Evaluation of liver diffu- sion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences prospective study in 66 patient s显示文摘 | Taouli B Vilgrain V Dumont E | 2003 | Radiology2003，226，1： | 1 |
| 10 | Histologie scoring of liver biopsy in focal nodular hyperplasia with atypical presentation 显示文摘 | Fabre A Auder P Vilgrain V | 2002 | Hepatoloty2002，35，2： | 1 |
| 11 | Evaluation of liver diffusion isotropy and characterization of focal hepatic lesion with two single shot echo--planar MR imaging sequences: prospective study in 66 patients显示文摘 | Taouli B Vilgrain V Dumont E | 2003 | Radiology2003，226，1： | 1 |
| 12 | Imaging of atypical hemangiomas of the liver with pathologic correlation显示文摘 | Vilgrain V Boulos L Vullierme M | 2000 | RadioGraphics2000，20，2： | 1 |
| 13 | Hepatic nodules in BuddChiari syndrome:imaging features显示文摘 | Vilgrain V Lewin M Vons C | 1999 | Radiology1999，210，2： | 1 |
| 14 | Atrophy-hyper- trophy complex in patients with cavernous transformation of the portal vein: CT evaluation 显示文摘 | Vilgrain V Condat B Bureau C | 2006 | Radiology2006，241，1： | 1 |
| 15 | The changingscene of hepatic vein thrombosis: recognition of a symptomatic cases显示文摘 | Hadengue A Poliquin M Vilgrain V | 1994 | Gastroenterology1994，106，4： | 1 |
| 16 | Advancement in HCC imaging: diagnosis, staging and treatment efficacy assessments显示文摘 | Valérie Vilgrain | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，4： | 1 |
| 17 | Telangiectatic focal nodular hyperplasia:US,CT,and MR imaging findings with histopathologic correlation in 13cases显示文摘 | Attal P Vilgrain V Brancatelli G | 2003 | Radiology2003，228，2： | 1 |
| 18 | Splanehnie vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation 显示文摘 | Francoz C Belghiti J Vilgrain V | 2005 | Gut2005，54，2： | 1 |
| 19 | Focal nodular hyperplasia of the liver: MR imaging and pathologic correlation in 37 patients显示文摘 | Vilgrain V Flejou JF Arrive L | 1992 | Radilolgy1992，184，3： | 1 |
| 20 | Expressional regulation of the angiopoietin-1 and -2 and the endothelial-specific receptor tyrosine kinase Tie2 in adrenal atrophy: a study of adrenocorticotropin- induced repair显示文摘 | Feraud O Mallet C Vilgrain I | 2003 | Endocrinology2003，144，10： | 1 |
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