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| 1 | Total and not bevacizumab-bound vascular endothelial growth factor as potential predictive factors to bevacizumab-based chemotherapy in colorectal cancer显示文摘AIM: To identify suitable biomarkers of response to bevacizumab(BV)- it remains an open question. The measurement of serum vascular endothelial growth factor(VEGF) has been proposed as a predictive factor for this drug, even if literature data are contradictory. METHODS: We prospectively evaluated the role of BV, total and not BV-bound VEGF and angiopoietin-2(Ang-2) serum levels as potential predictive factors of response for BV in combination with an oxaliplatinbased chemotherapy. BV, Ang-2, total and not BVbound VEGF levels were measured at baseline, before 2^(nd) and 5^(th) cycle of oxaliplatin-based chemotherapy in 20 consecutive metastatic colorectal cancer patients. RESULTS: Results were correlated to response to treatment. Variability in BV levels have been found, with decreased level in less responding patients. In particular, the concentration of BV increased of 3.96 ± 0.69 folds in serum of responsive patients after 3 more cycles of therapy compared to those with stable or progressive disease with a 0.72 ± 0.25 and 2.10 ± 0.13 fold increase, respectively. The determination of free and total VEGF demonstrated that the ratio between the two values, evaluated immediately before the 2^(nd) and the 5^(th) cycle of therapy, decreased from 26.65% ± 1.33% to 15.50% ± 3.47% in responsive patients and from 53.41% ± 4.75 to 34.95% ± 2.88% in those with stable disease. Conversely, in those with progression of disease, the ratio showed the opposite behavior coming up from 25.99% ± 5.23% to 51.71% ± 5.28%. The Ang-2 levels did not show any relationship. CONCLUSION: Our data show that the ratio of not BV-bound VEGF to total VEGF serum and BV plasma concentrations for predicting the response to BV plus oxaliplatin-based chemotherapy could be a promising biomarker of response to BV. | Amalia Azzariti Letizia Porcelli Oronzo Brunetti Marzia Del Re Vito Longo Patrizia Nardulli Michele Signorile Jian-Ming Xu Angela Calabrese Anna Elisa Quatrale Evaristo Maiello Vito Lorusso Nicola Silvestris | 2016 | World Journal of Gastroenterology2016，22，27： | 4 |
| 2 | Target Therapies in Pancreatic Carcinoma显示文摘 | Nicola Silvestris Antonio Gnoni Anna Elisabetta Brunetti Leonardo Vincenti Daniele Santini Giuseppe Tonini Francesca Merchionne Evaristo Maiello Vito Lorusso Patrizia Nardulli Amalia Azzariti Michele Reni | 2014 | Current Medicinal Chemistry2014，，8： | 2 |
| 3 | Regulation of pro-gesterone receptor messenger ribonucleic acid and protein levels in MCF-7 cells by estradial:Analysis of estrogen's effect on pro-gesterone receptor synthesis and degradation显示文摘 | Nardulli AM Greene GL O'Malley BW | 1988 | Endocrinology1988，122，3： | 1 |
| 4 | Meissner masses in the gCFL phase of QCD显示文摘 | R. Casalbuoni R. Gatto M. Mannarelli G. Nardulli M. Ruggieri | 2004 | Physics Letters B2004，，3： | 1 |
| 5 | Clinical and economic ef- fects of central venous catheters on oncology patient care 显示文摘 | Console G Calabro C Nardulli P | 2007 | J Chemother2007，19，3： | 1 |
| 6 | Estrogen response element function as allosteric modulators of estrogen receptor conformation显示文摘 | Greene GL Nardulli AM | 1998 | Mol Cell Biol1998，18，4： | 1 |
| 7 | APO(a) variants and lipoprotein(a) in men with or without myocardial infarction显示文摘 | Chimienti G Lamanuzzi BL Nardulli M etal | 2002 | Exp Mol Pathol2002，73，1： | 1 |
| 8 | Inhibiting adenosine deaminase modulates the systemic inflammatory response syndrome in end-otoxemia and sepsis显示文摘 | Adanin S Yalovetskiy IV Nardulli BA | | 0，，05： | 1 |
| 9 | Estrogen receptor alpha and Spl regulate progesterone receptor gene expression显示文摘 | Schuhz JR Petz LN Nardulli AM | 2003 | Mol Cell Endocrinol2003，201，12： | 1 |
| 10 | 17β-estradiol increases expression of the oxidative stress response and DNA repair protein apurinie endonuelease (Apel) in the cerebral cortex of female mice following hypoxia 显示文摘 | Dietrich AK Humphreys GI Nardulli AM | 2013 | Steroid Biochem Mol Biol2013，138，： | 1 |
| 11 | ERa-associated protein networks 显示文摘 | Schultz-Norton JR Ziegler YS Nardulli AM | 2011 | Trends E ndoerinol Metab2011，22，4： | 1 |
| 12 | Chaos in Neural Networks with a Nonmonotonic Transfer Function显示文摘 | Caroppo D Mannarelli M Nardulli G | 1999 | Physical Review-E1999，60，2： | 1 |
| 13 | ERa - associated protein networks显示文摘 | Schultz - Norton JR Ziegler YS Nardulli AM | 2011 | Trends in Endocrinology and Metabolism2011，22，4： | 1 |
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