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	题名	作者	年代	出处	被引量
1	Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival显示文摘Autophagy is a cellular self-eating process essential for stress response and maintainingtissue homeostasis by lysosomal degradation of unwanted or damaged proteins and organelles.Here, we show that cells with defective mitochondria induce autophagy to promotecell survival through activating the AMPK pathway. Loss of mitochondrial complex III proteincytochrome b activates the AMPK signaling and induced autophagy. Inhibiting mitochondria energeticsby mitochondria-targeted agents activates the AMPK signaling and induced autophagy.Genetic inhibition of AMPK inhibits autophagy induction in cells with defective mitochondria,while genetic inhibition of autophagy has no effect on AMPK activation. Mitochondria dysfunctionhas no effect of DNA repair of UV-induced DNA damage. However, mitochondria dysfunctionsensitizes cells to apoptosis induced by UV radiation. Genetic inhibition of autophagy orAMPK sensitized cells to apoptosis in cells with defective mitochondria. Our results demonstratethat AMPK and autophagy senses mitochondria dysfunction and serves as a mechanismfor survival. Our findings may provide new insights into the interplay between mitochondriafunction and autophagy process in maintaining tissue homeostasis, and suggest that this interactionmay play important roles in diseases such as cancer and neurodegeneration.	Baozhong Zhao Lei Qiang Joy Joseph Balaraman Kalyanaraman Benoit Viollet Yu-Ying He	2016	Genes & Diseases2016，3，1：	6
2	Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state显示文摘	Foretz Marc Hébrard Sophie Leclerc Jocelyne Zarrinpashneh Elham Soty Maud Mithieux Gilles Sakamoto Kei Andreelli Fabrizio Viollet Benoit	2010	Journal of Clinical Investigation2010，，7：	2
3	Knockout of thealpha2 but not alpha 15’- AMP -activated protein kinaseisoform abolishes 5 -aminomiadazole -4 -carboxamide -1 -beta -4 -ribofuranside but not contraction - induced glucose uptake inskeletal muscle显示文摘	Jorgensen S B Viollet B Andreelli F	2004	J Biol Chem2004，279，：	1
4	Cellular and molecular mechanisms of metformin:an overview显示文摘	Viollet B Guigas B Sanz Garcia N	2012	Clin Sci(Lond)2012，122，6：	1
5	Neuroprotective effects of adenoshae monophosphate-activated protein kinase inhibkion and gene deletion in stroke显示文摘	Li J Zeng Z Viollet B	2007	Stroke2007，38，：	1
6	The anti-diabetic drug metformin does not affect bone mass in vivo or fracture healing显示文摘	Jeyabalan J Viollet B Smitham P	2013	Osteoporos Int2013，24，10：	1
7	Identification and characterization of a spinal muscular atrophy-determining gene显示文摘	Leeibvres S Burglen L Reboullet S Clermont O Burlet P Viollet L	1995	Cell1995，80，1：	1
8	AMPK and mTOR regulate autophagy through direct phosphorylation of Ulkl 显示文摘	Kim J Kundu M Viollet B	2011	Nat Cell Biol2011，13，2：	1
9	AMPK and roTOR relate attmphagy through direct phosphorylation of Ulkl 显示文摘	KimJ Kundu M Viollet B	2011	Nat Cell Biol2011，13，2：	1
10	Mapping ofautosomal recessive chronic distal spinal muscular atrophy to chromosome 11 q13 显示文摘	Viollet L Barois A Rebeiz JG	2002	Ann Neurol2002，51，5：	1
11	AMP-activated protein kinase pathway and bone metabolism显示文摘	Jeyabalan J Shah M Viollet B	2012	J Endo- crinol2012，212，3：	1
12	AMPK and mTOR regulate autophagy through direct phosphorylation of Ulkl 显示文摘	Kim J Kundu M Viollet B	2011	Nat Cell Biol2011，13，2：	1
13	Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice.显示文摘	Heeseog Kang Benoit Viollet Dianqing Wu	2013	Journal of Biological Chemistry2013，，32：	1
14	Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders显示文摘	Viollet B Foretz M Guigas B	2006	J Physiol2006，574，1：	1
15	Activation of AMP - activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders显示文摘	Viollet B Foretz M Guigas B	2006	J Physiol2006，1574，：	1
16	Induced adiposity and adipoeyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit 显示文摘	Villena JA Viollet B Andreelli F Kahn A Vaulont S Sul HS	2004	Diabetes2004，53，9：	1
17	AMPK and m TOR regulate autophagy through direct phosphorylation of Ulk1显示文摘	Kim J Kundu M Viollet B	2011	Nature Cell Biology2011，13，2：	1
18	AMP-activated protein ki- nase in the regulation of hepatic energy metabolism:From physi- ology to thera- peutic perspectives 显示文摘	Viollet B Guigas B Leclerc J	2009	Acta Physiol2009，196，1：	1
19	Activation of AMP-Activated Protein Kinase in the Liver:a New Strategy for the Management of Metabolic Hepatic Disorders显示文摘	Viollet B Foretz M Guigas B	2006	J Physio12006，574，1：	1
20	Targeting AMP - activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders 显示文摘	Viollet B Mounier R Leclerc J	2007	Diabetes Metab2007，33，6：	1

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