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| 1 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 2 | Functionalization of Single- and Multi-Walled Carbon Nanotubes with Cationic Amphiphiles for Plasmid DNA Complexation and Transfection显示文摘The possibility of delivering DNA effi ciently to cells represents a crucial issue for the treatment of both genetic and acquired diseases.However,even although the effi ciency of non-viral transfection systems has improved in the last decade,none have yet proven to be suffi ciently effective in vivo.We report herein our results on the functionalization of single-walled carbon nanotubes(SWNT)and multi-walled carbon nanotubes(MWNT)by two cationic amphiphiles(lipid RPR120535 and pyrenyl polyamine),their use for the complexation of plasmid DNA,and their efficiency in transfecting cells in vitro.The experiments have shown that the efficiency of transfection is higher when using SWNT instead of MWNT,and that transfection effi ciency is similar or slightly higher when using nanoplexes(SWNT/lipid RPR120535/DNA)instead of lipoplexes(lipid RPR120535/DNA)and several orders of magnitude higher than that of naked DNA.This study therefore shows both that the transfection is better when using SWNTs and that it is dependent on the nature of the amphiphilic molecules adsorbed on the nanotubes. | Cyrille Richard Nathalie Mignet Céline Largeau Virginie Escriou Michel Bessodes Daniel Scherman | 2009 | Nano Research2009，2，8： | 3 |
| 3 | Pharmaeogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38 显示文摘 | VIRGINIE C RICARDO B DELPHINE M | 2004 | Clln Pharmacol Ther2004，76，6： | 1 |
| 4 | Characterization and reactivity in toluene reforming of a Fe/ olivine catalyst designed for gas cleanup in biomass gasification 显示文摘 | VIRGINIE M COURSON C NIZNANSKY D CHAOUI N KIENNEMANN A | 2010 | Appl Catal B: Environ2010，101，12： | 1 |
| 5 | The opgGlH and opgC genes of Rhodobacter sphaeroides form an operon that controls backbone synthesis and succinylation of osmoregulated periplastoic glueans 显示文摘 | Virginie C Evgueni G Agnes P | 2002 | Eur J Biochem2002，269，： | 1 |
| 6 | 'Real equilibrium exchange rate in China is the Renminbi undervalued?'显示文摘 | Coudert Virginie Cécile Couharde | | 0，，04： | 1 |
| 7 | Identification of the atomic scale structure of the La 0.65 Nd 0.15 Mg 0.20 Ni 3.5 alloy synthesized by spark plasma sintering显示文摘 | Virginie Serin Junxian Zhang César Magén Rapha?l Serra Martin J. H?tch Lucille Lemort Michel Latroche Manuel Ricardo Ibarra Bernard Knosp Patrick Bernard | 2013 | Intermetallics2013，，： | 1 |
| 8 | 'Does euro or dollar pegging impact the real exchange rate? The case of oil and commodity currencies,'显示文摘 | Coudert Virginie Cécile Couharde Valérie Mignon | | 0，，09： | 1 |
| 9 | Experimental study of free growth of equiaxed NH4CI crystals settling in undercooled NH4CI-H20 melts 显示文摘 | Beno:t A Virginie A Herv6 C | 1999 | ISIJ International1999，39，： | 1 |
| 10 | The Npro product of clas- sical swine fever vires interacts with IkBa, the NF-kB inhibitor 显示文摘 | Virginie D Bryan C Helen C | 2008 | J Gen Virol2008，89，： | 1 |
| 11 | Human bisphosphoglycerate mutase显示文摘 | GAREL M C VIRGINIE J PHILIPPE LE BOULCH | 1989 | Journal of Biological Chemistry1989，264，18： | 1 |
| 12 | Effect of Fe-olivineon the tar content during biomass gasification in a dual fluidizedbed显示文摘 | Virginie M Adanez J Courson C Diego L F Garcia-Labiano F Niznansky D Kiennemann A Gayan P Abad A | 2012 | Applied Catalysis B: Environmental2012，，： | 1 |
| 13 | Effect of Fe-olivine on the tar content during biomass gasification in a dual fluidized bed显示文摘 | Virginie M Adánez J Courson C | 2012 | Applied Catalysis B:Environmental2012，，： | 1 |
| 14 | Heavy metals, organochlorines and polycyclic aromatic hy?drocarbons in sperm whales stranded in the southern North Sea during the 199411995 winter显示文摘 | Hoolsbeek L Joiris C R Debacker Virginie Rosse P Nellis?sen J P Gobert Sylvie Bouquegneau Jean-Marie Bossicart M | 1999 | Mar Poll Bull1999，38，4： | 1 |
| 15 | Blue- green Light- emitting Diodes and Electrochemical Cells Based on a Copolymer Derived from Fluorine显示文摘 | Olivier S Virginie C Jean- Claude V Michel A | 2000 | Synthetic Metal2000，113，： | 1 |
| 16 | Use of urban composts for the regeneration of a burnt Mediterranean soil: A laboratory approach显示文摘 | Antoine Cellier Cédric Francou Sabine Houot Christine Ballini Thierry Gauquelin Virginie Baldy | 2010 | Journal of Environmental Management2010，，： | 1 |
| 17 | Comparative genotoxicity of aluminium and cadmium on embryonic zebrafish cells显示文摘 | Sandrine P Isabelle C Virginie C | 2012 | Mutation Research2012，7，7： | 1 |
| 18 | Study on the microalgal pigments extraction process : Performance of microwave assis- ted extraction 显示文摘 | Virginie P Jean - ren6 C Firas F | 2011 | Process Biochemistry2011，46，： | 1 |
| 19 | Runx2 and HDAC3 mediated-repression is relieved in differentiating human osteoblast cells to allow high BSP expression 显示文摘 | Virginie L Cedric D Vincent C | 2007 | Bone2007，，12： | 1 |
| 20 | Effects of GPD 1 Over expression in Saccharomyces cerevisiae commercial wine yeast strains lacking ALD6 genes 显示文摘 | BRIGITTE C VIRGINIE M FABIENNE R | 2006 | Appl Environ Microbiol2006，，： | 1 |
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