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| 1 | Autoimmune pancreatitis misdiagnosed as a tumor of the head of the pancreas显示文摘Autoimmune pancreatitis can mimic pancreatic cancer in its clinical presentation, imaging features and laboratory parameters. Differentiating between those two entities requires implementation of clinical judgment and experience along with objective parameters that may suggest either condition. Few strategies have been proposed for the surgeon to implement when facing borderline cases. The following case is an example of a clinical scenario compatible with an accepted algorithm for diagnosis of pancreatic cancer, which eventually proved wrong. We present a 75-year-old patient who was admitted for obstructive jaundice. Imaging features were highly suggestive for pancreatic cancer as was the carbohydrate antigen 19-9 (CA 19-9) level, leading to a decision for surgery. Pathological examination revealedautoimmune pancreatitis. Though no frank carcinoma was found, premalignant ductal changes of pancreatic intraepithelial neoplasia (PanIN)Ⅰand PanIN Ⅱ were discovered throughout the pancreatic duct. Caution is advised when relying on the combination of highly suggestive radiology features and elevated levels of CA 19-9 in the diagnosis of pancreatic cancer. When the tissue diagnosis is not conclusive, obtaining IgG4 and antinuclear Ab levels is advised, to rule out the rare possibility of autoimmune pancreatitis. Patients with autoimmune pancreatitis should be followed carefully as precancerous lesions may accompany the benign disease and the correlation of these two entities has not been ruled out. | Eran Brauner Jesse Lachter Offir Ben-Ishay Euvgeni Vlodavsky Yoram Kluger | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 4 |
| 2 | Heparanase: busy at the cell surface显示文摘 | Liat Fux Neta Ilan Ralph D. Sanderson Israel Vlodavsky | 2009 | Trends in Biochemical Sciences2009，，10： | 3 |
| 3 | Rectal bleeding as a presenting symptom of AL amyloidosis and multiple myeloma显示文摘Amyloidosis of the gastrointestinal tract is a rare disease that presents with common,nonspecific signs and symptoms.It may affect any part of the gastrointestinal tract from mouth to anus.The clinical and endoscopic features are diverse and may mimic other diseases,such as inflammatory bowel disease,malignancy,ischemic colitis and,at times,collagenous colitis.We describe an uncommon case of rectal bleeding and anemia with polypoid lesions and ulcerations in the colon,as the presenting symptom of AL amyloidosis and light chain multiple myeloma. | Itay Maza Evgene Vlodavsky Rami A Eliakim | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，1： | 2 |
| 4 | Significance of Heparanase in Cancer and Inflammation显示文摘 | Israel Vlodavsky Phillip Beckhove Immanuel Lerner Claudio Pisano Amichai Meirovitz Neta Ilan Michael Elkin | 2012 | Cancer Microenvironment2012，，2： | 2 |
| 5 | Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma显示文摘 | Bonertz Andreas Weitz Jürgen Pietsch Dong-Ho Kim Rahbari Nuh N Schlude Christoph Ge Yingzi Juenger Simone Vlodavsky Israel Khazaie Khashayarsha Jaeger Dirk Reissfelder Christoph Antolovic Dalibor Aigner Maximilian Koch Moritz Beckhove Phili | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
| 6 | Substrate specificity of heparanases from human hepatoma and platelets 显示文摘 | Pikas DS Li JP Vlodavsky I | 1998 | J Biol Chem1998，273，18： | 1 |
| 7 | Expression of heparanase in normal, dysplastic and neoplastic human colon mucosa and stroma显示文摘 | Friedmann Y Vlodavsky I Aingorn H | 2000 | Am J Pathol2000，157，： | 1 |
| 8 | Mammalian heparanase:gene cloning,expression and function in tumor progression and metastasis显示文摘 | Vlodavsky I Friedmann Y Elkin M | 1999 | Nat Med1999，5，： | 1 |
| 9 | Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes显示文摘 | Sommerfeldt N Beckhove P Ge Y Sehutz F Choi C Bucur M Domsehke C Sohn C Sehneeweis A Rom J Poll- mann D Leneht D Vlodavsky I Sehirrmaeher V | 2006 | Cancer Res2006，66，15： | 1 |
| 10 | Anti-heparanase monoclonal antibody enhances heparanase enzymatic activity and facilitates wound healing显示文摘 | Gingis-Velitski S Ishai-Michaeli R Vlodavsky I | 2007 | FASEB J2007，21，14： | 1 |
| 11 | Mammalian heparanase as mediator of tumor metastasis and angiogenesis显示文摘 | Vlodavsky I Elkin M Pappo O | 2000 | Isr Med Assoc J2000，2，9： | 1 |
| 12 | Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis 显示文摘 | Vlodavsky Yael Frienmann Michael Elkin | 1999 | Nature Medicine1999，1，5： | 1 |
| 13 | Heparanase : structure, biological functions, and inhibition by heparin-derived mimetics of heparan sul- fate 显示文摘 | Vlodavsky I IIan N Naqqi A | 2007 | Curr Pharm Des2007，13，20： | 1 |
| 14 | Mammalian heparnase:Gene cloning,expressing and function in tumor progression and metastasis显示文摘 | Vlodavsky I Friedmann Y Elkin M | 1999 | Nat Med1999，5，7： | 1 |
| 15 | Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate显示文摘 | Vlodavsky I Ilan N Naggi A | 2007 | Curt Pharm Des2007，13，20： | 1 |
| 16 | Molecular proper- ties and involvement of heparanase in Cancer progression and nor- real development显示文摘 | Vlodavsky I Goldshmidt O Zeharia E | 2001 | Bioehimie2001，83，8： | 1 |
| 17 | Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties显示文摘 | Eilam Palzur Menashe Zaaroor Eugene Vlodavsky Felix Milman Jean F. Soustiel | 2008 | Brain Research2008，，： | 1 |
| 18 | An ELISA method for the detection and quantification of human heparanase显示文摘 | Shafat I Zcharia E Nisman B Nadir Y Nakhoul F Vlodavsky I | 2006 | Biochem Biophys Res Commun2006，341，： | 1 |
| 19 | Heparanase in glomerular diseases显示文摘 | van den Hoven M J Rops A L Vlodavsky I | 2007 | Kidney Int2007，72，5： | 1 |
| 20 | Mammalian heparanase as mediator of tumor metastasis and angiogenesis显示文摘 | Vlodavsky I Elkin M Pappo O | 2000 | Isr Med Assoc J2000，，： | 1 |
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