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| 1 | Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge显示文摘While the incidence of gastric cancer has decreased worldwide in recent decades,the incidence of signetring cell carcinoma(SRCC) is rising. SRCC has a specific epidemiology and oncogenesis and has two forms: early gastric cancer,which can be resected endoscopically in some cases and which has a better outcome than non-SRCC,and advanced gastric cancer,which is generally thought to have a worse prognosis and lower chemosensitivity than non-SRCC. However,the prognosis of SRCC and its chemosensitivity with specific regimens are still controversial as SRCC is not specifically identified in most studies and its poor prognosis may be due to its more advanced stage. It therefore remains unclear if a specific therapeutic strategy is justified,as the benefit of perioperative chemotherapy and the value of taxanebased chemotherapy are unclear. In this review we analyze recent data on the epidemiology,oncogenesis,prognosis and specific therapeutic strategies in both early and advanced SRCC of the stomach and in hereditary diffuse gastric cancer. | Simon Pernot Thibault Voron Geraldine Perkins Christine Lagorce-Pages Anne Berger Julien Taieb | 2015 | World Journal of Gastroenterology2015，21，40： | 30 |
| 2 | Colorectal cancer and immunity:what we know and perspectives显示文摘Strong evidence supports the concept of immunosurveillance and immunoediting in colorectal cancer.In particular,the density of T CD8+and CD45+lymphocyte infiltration was recently shown to have a better prognostic value than the classic tumor node metastasis classification factor.Other immune subsets,as macrophages,natural killer cells or unconventionnal lymphocytes,seem to play an important role.Induction of regulatory T cells(Tregs)or immunosuppressive molecules such as PD-1 or CTLA-4 and downregulation of antigen-presenting molecules are major escape mechanisms to antitumor immune response.The development of these mechanisms is a major obstacle to the establishment of an effective immune response,but also to the use of immunotherapy.Although im-munotherapy is not yet routinely used in colorectal cancer,we now know that most treatments used(chemotherapy and biotherapy)have immunomodulatory effects,such as induction of immunogenic cell death by chemotherapy,inhibition of immunosuppression by antiangiogenic agents,and antibody-dependent cytotoxicity induced by cetuximab.Finally,many immunotherapy strategies are being developed and tested in phaseⅠtoⅢclinical trials.The most promising strategies are boosting the immune system with cytokines,inhibition of immunoregulatory checkpoints,vaccination with vectorized antigens,and adoptive cell therapy.Comprehension of antitumor immune response and combination of the different approaches of immunotherapy may allow the use of effective immunotherapy for treatment of colorectal cancer in the near future. | Simon Pernot Magali Terme Thibault Voron Orianne Colussi Elie Marcheteau Eric Tartour Julien Taieb | 2014 | World Journal of Gastroenterology2014，20，14： | 19 |
| 3 | Interest of preoperative im- munonutrition in liver resection for cancer: study protocol o~ the PROPILS trial, a multicenter randomized controlled phase IV trial显示文摘 | Ciacio O Voron T Pittau G | 2014 | BMC Cancer2014，14，： | 1 |
| 4 | 显示文摘 | lakunina N Shestakova MV Voron'ko OE | 2005 | Genetika2005，41，7： | 1 |
| 5 | Spectroscopy of Yb^2+ in Cubic ZrO2 Crystals 显示文摘 | Voron'ko Yu K Vishrtyakova M A Lomonova E E | 2004 | Inoranie Materials2004，40，5： | 1 |
| 6 | Promoter polymorphisms of UCP1, UCP2, and UCP3 are not associated with diabetic microvascular complications in type 2 diabetes 显示文摘 | Rudofsky G Jr Schrodter A Voron'ko OE | 2007 | Horm Metab Res2007，39，4： | 1 |
| 7 | Rheological Properties of Gels of Gelatin with Sodium Alginate显示文摘 | Voron'Kong Derkach S R Izmailova V N | 2002 | Russion Journal of Applied Chemistry2002，75，5： | 1 |
| 8 | Control of the immune response by pro-angiogenic factors显示文摘 | Voron T Marcheteau E Pernot S | 2014 | Front Oncol2014，4，： | 1 |
| 9 | Raman spectra and phase transformations of the MLn(WO4)2 (M = Na, K; Ln = La, Gd, Y, Yb) tungstates显示文摘 | Yu. K. Voron’ko A. A. Sobol S. N. Ushakov L. I. Tsymbal | 2000 | Inorganic Materials2000，，9： | 1 |
| 10 | Multiple lentigines syndrome:case report and review of the literature显示文摘 | David A Voron D Hatfield H | | 0，，03： | 1 |
| 11 | Control of the immune response by pro-angiogenic factors显示文摘 | Voron T Marcheteau E Pemot S | 2014 | Front Oncol2014，4，： | 1 |
| 12 | Growth and spectroscopic investigations of Yb3+-doped NaGd(MoO4)2 and NaLa(MoO4)2-new promising laser crystals显示文摘 | Voron'ko Yu K Subbotin K A Shukshinet V E | 2006 | Optical Materials2006，29，： | 1 |
| 13 | Multiple lentigines syndrome: case report and review of the literature显示文摘 | Voron DA Hatfield HH Kalkhoff RK | 1976 | Am J Med1976，60，3： | 1 |
| 14 | Control of immune response by pro-angiogenic factors显示文摘 | Voron T Marcheteau E Pernot S | 2014 | Front Oncol2014，4，： | 1 |
| 15 | Association of interleukin - 13 gene polymorphisms with atopic bronchial asthma 显示文摘 | Dmitrieva - Zdorova EV Voron'ko OE Aksenova MG | 2010 | Genetika2010，46，1： | 1 |
| 16 | On Resistance of Forests Against Influence of Industrial Emissions显示文摘 | Pastemak P S Voron V P Pristupa G K | 1985 | Lesnoe Khozyaistvo1985，，9： | 1 |
| 17 | A search for association between the polymorphic markers of PON1 and PON2 genes and diabetic nephropathy in patients with type I diabetes mellitus显示文摘 | Voron'ko OE Iakunina NIu Shestakova MV | 2005 | Genetika2005，41，6： | 1 |
| 18 | A search for association between the polymorphic markers of PONI and PON2 genes and diabetic nephropathy in patients with type I diabetes mellitus显示文摘 | Voron'ko OE Iakunina NIu Shestakova MV | 2005 | Genetika2005，41，6： | 1 |
| 19 | 印戒细胞癌是否为胃癌的特殊类型?显示文摘背景和目的胃癌中印戒细胞(signet-ring cell,SRC)癌的预后及其化疗耐药性已有文献报道并存在争议。对此类肿瘤围手术期化疗的作用仍然存在质疑。本研究意欲评估在接受根治性切除术的SRC癌的预后。同时,比较非SRC癌和SRC癌的预后影响因素(其中包括围手术期化疗)。方法本研究为回顾性研究,参加单位包括法国的19个医疗中心。共纳入接受手术治疗的1799例连续胃腺癌病例,手术方式包括胃次全切除和全胃切除术。对胃窦癌行D2淋巴结清扫,对胃上部癌行改良的D2淋巴结清扫。SRC癌的诊断依据为病灶中存在含黏蛋白的孤立细胞群。结果共979(54.4%)例患者接受全胃切除。共899(50%)例患者诊断为SRC癌。较非SRC癌相比,SRC癌多发于女性、青年及营养不良患者,并ASA评分较低、肿瘤更大。非SRC及SRC癌患者的中位生存期分别为51个月、26个月(P<0.001)。多因素分析表明,SRC癌为胃癌的独立预后不良因素(HR=1.182)。年龄>60岁、皮革胃、邻近脏器侵犯为SRC癌患者预后的不良因素,但不是非SRC胃癌患者的预后因素。相比于非SRC癌患者,术前及术后化疗对接受切除手术的SRC癌患者的预后无显著影响。结论相比于非SRC癌,SRC癌的预后不良、预后影响因素存在差异、围手术期的化疗敏感度差。因此,在将来的治疗相关研究中,非SRC癌及SRC癌应作为不同类型处理。 | Voron T Messager M Duhamel A 吴晖 | 2015 | 消化肿瘤杂志(电子版)2015，7，4： | 0 |
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