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| 1 | Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights显示文摘AIM To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157. METHODS Medication [BPC 157,L-NAME,L-arginine(alone/combined),saline] was bath at the blood deprived colon segment. During reperfusion,medication was BPC 157 or saline. We recorded(USB microscope camera) vessel presentation through next 15 min of ischemic colitis(ICrats) or reperfusion(removed ligations)(IC + RL-rats);oxidative stress as MDA(increased(IC-and IC + RLrats)) and NO levels(decreased(IC-rats);increased(IC + RL-rats)) in colon tissue. IC + OB-rats [IC-rats had additional colon obstruction(OB)] for 3 d(IC + OBrats),then received BPC 157 bath. RESULTS Commonly,in colon segment(25 mm,2 ligations on left colic artery and vein,3 arcade vessels within ligated segment),in IC-,IC + RL-,IC + OB-rats,BPC 157(10 μg/kg) bath(1 m L/rat) increased vessel presentation,inside/outside arcade interconnections quickly reappeared,mucosal folds were preserved and the pale areas were small and markedly reduced. BPC 157 counteracted worsening effects induced by L-NAME(5 mg) and L-arginine(100 mg). MDA-and NO-levels were normal in BPC 157 treated IC-rats and IC + RLrats. In addition,on day 10,BPC 157-treated IC + OBrats presented almost completely spared mucosa with very small pale areas and no gross mucosal defects;the treated colon segment was of normal diameter,and only small adhesions were present.CONCLUSION BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals. This effect involves the NO system. | Antonija Duzel Josipa Vlainic Marko Antunovic Dominik Malekinusic Borna Vrdoljak Mariam Samara Slaven Gojkovic Ivan Krezic Tinka Vidovic Zdenko Bilic Mario Knezevic Marko Sever Nermin Lojo Antonio Kokot Marijan Kolovrat Domagoj Drmic Jaksa Vukojevic Tamara Kralj Katarina Kasnik Marko Siroglavic Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，48： | 2 |
| 2 | Determination of CI-,Br-,I-,Mn2+,malonic acid and quercetin by perturbation of a non-equilibrium stationary state in the Bray-Liebhafsky reaction显示文摘 | Vukojevic V.B Pejic N.D Stanisavljev D.R | | 0，，： | 1 |
| 3 | Removal of zinc, copper and lead by natural zeo- lite: a comparison of adsorption isotherms显示文摘 | PERIC J TRGO M VUKOJEVIC MEDIVIDOVIC N | 2004 | Water Research2004，38，7： | 1 |
| 4 | Antioxidant protective effects of mushroom metabolites 显示文摘 | Stajic M Vukojevic J Knezevic A | 2013 | Current Topics in Medicinal Chemistry2013，13，21： | 1 |
| 5 | Antioxidant protective effects of mushroom metabolites 显示文摘 | Stajic M Vukojevic J Knezevic A | 2013 | Current Topics in Medicinal Chemistry2013，13，21： | 1 |
| 6 | Wheat straw conversion by enzymatic system of Ganedenna lucidum显示文摘 | Stajic M Kukavica B Vukojevic J et ol | 2010 | BioResources2010，5，4： | 1 |
| 7 | Differential Growth Inhibition of Diaporthe and Phomopsis Isolates by the Metabolic Activity of Five Actinomycetes显示文摘 | MUNTA lqOLA-CVETKOVIC M VUKOJEVIC J MIHALJCEVIC M | 2000 | Journal of Phytopathology2000，148，5： | 1 |
| 8 | YY1 binding to a subset of p53 DNA-target sites regulates p53-dependent transcription显示文摘 | Yakovleva T Kolesnikova L Vukojevic V | 2004 | Biochem Biophys Res Commun2004，318，2： | 1 |
| 9 | Chemical composition of essential oils of Thymus and Mentha species and their antifungal activities显示文摘 | Sokovic M D Vukojevic J Marin P D | 2009 | Molecules2009，14，： | 1 |
| 10 | Nestin expression in glial and neuronal progenitors of the developing human spinal ganglia显示文摘 | Katarina Vukojevic Danijel Petrovic Mirna Saraga-Babic | 2009 | Gene Expression Patterns2009，，2： | 1 |
| 11 | Removal of Zinc,Copper and Lead by nature zeolites comparison of adsorption isotherm显示文摘 | Peric J Trgo M Vukojevic N | 2004 | Water Research2004，38，17： | 1 |
| 12 | Aging and a long-term diabetes mellitus increase expression of 1 alpha-hydroxylase and vitamin D receptors in the rat liver显示文摘 | Vuica A Ferhatovic Hamzic L Vukojevic K | 2015 | Exp Gerontol2015，72，： | 1 |
| 13 | Determinate ion of C1^- , Br , I , Mn^2+, malonic acid and quercetin by perturbation of a non- equilibrium stationary state in the Bray-Liebhafsky reaction显示文摘 | VUKOJEVIC V B PEJIC N D STANISAVLJEV D R | 1999 | Analyst1999，124，： | 1 |
| 14 | Copy numbervariation analysis identifies novel CAKUT candidate genes inchildren with a solitary functioning kidney显示文摘 | Westland R Verbitsky M Vukojevic K | 2015 | Kidney Int2015，8，6： | 1 |
| 15 | Differential Growth Inhibition of Diaporthe and Phomopsis Isolates by the Metabolic Activity of Five Actinornycetes显示文摘 | M Munta nola-Cvetkovic J Vukojevic M Mihaljcevic | 2000 | Journal of Phytopathology2000，148，5： | 1 |
| 16 | Quantitative study of synthetic Hox transcription factor-DNA interactions in live cells显示文摘 | VUKOJEVIC V PAPADOPOULOS D K TERENIUS L | 2010 | Proc Natl Acad Sci2010，107，9： | 1 |
| 17 | Removal of zinc, copper and lead by natural zeolite - a comparison of ad- sorption isotherms 显示文摘 | PERIC J TRGO M VUKOJEVIC N | 2004 | Water Research2004，38，7： | 1 |
| 18 | Anticoagulant effects of idraparinux after termination of therapy for prevention of recurrent venous thromboembolism:observations from the van Gogh trials 显示文摘 | Harenberg J Jorg I Vukojevic Y | 2008 | Eur J Clin Pharmacol2008，64，6： | 1 |
| 19 | Bilateral endogenous Candida endophthalmitis after induced abortion显示文摘 | Sikic J Vukojevic N Katusic D | 2001 | Croat Med J2001，42，6： | 1 |
| 20 | Decreased CO production in methanol steam reforming over Cu/ZrOz catalysts prepared by the microemulsion technique显示文摘 | Ritzkopf L Vukojevic S Weidenthaler C | 2006 | Applied Catalysis A: General2006，302，2： | 1 |
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